Proliferation of osteoblast precursor cells on the surface of TiO2 nanowires anodically grown on a β-type biomedical titanium alloy

Fanton, Leonardo; Loría, Frida; Amores, Mario; Pazos, M. Ruth; Adán, Cristina; García-Muñiz, Rafael; Marugán, Javier

doi:10.1038/s41598-022-11981-4

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…The Al 2p peaks near 74 eV shown for the TAN and TAV alloy oxides indicate the presence of Al2O3 [5,[45][46][47]. The Nb 3d doublet at 207 and 210 eV indicates the presence of Nb2O5 in the TAN and TNZT surfaces [5,[45][46][47][48]. The peak intensity is much more pronounced in the TNZT oxide scans due to the higher concentration of Nb in the substrate alloy.…”

Section: Oxide Surface Characterizationmentioning

confidence: 96%

“…The Mo 3d doublet near 233 and 236 eV for both TiMo oxides indicates the presence of MoO3 [49]. The Zr 3d doublet near 133 and 135 eV indicates the presence of ZrO2 in the TNZT oxide; additionally, the Ta 4f doublet near 26 and 28 eV confirms the presence of Ta2O5 [48]. The V 2p scans of the TAV oxide are not presented due to negligible vanadium oxide peaks being detected.…”

Section: Oxide Surface Characterizationmentioning

confidence: 99%

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Photocatalytic Activity and Antibacterial Properties of Mixed-Phase Oxides on Titanium Implant Alloy Substrates

Johnson,

Donaho,

Ali

et al. 2024

Coatings

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Titanium alloys are commonly used for implants, but the naturally forming oxides are bioinert and not ideal for bacterial resistance or osseointegration. Anodization processes are a modification technique that can crystallize the oxides, alter oxide surface topography, and introduce beneficial chemistries. Crystalline titanium oxides are known to exhibit photocatalytic activity (PCA) under UVA light. Anodization was used to create mixed-phase oxides on six titanium alloys including commercially pure titanium (CPTi), Ti-6Al-4V (TAV), Ti-6Al-7Nb (TAN), two forms of Ti-15Mo (TiMo-β and TiMo-αβ), and Ti-35Nb-7Zr-5Ta (TNZT). Combined EDS and XPS analyses showed uptake of the electrolyte and substrate alloying elements into the oxides. The relative oxide PCA was measured using methylene blue degradation assays. CPTi and TAN oxides exhibited increased PCA compared to other alloys. Combined XRD and EBSD oxide phase analyses revealed an unfavorable arrangement of anatase and rutile phases near the outermost surfaces, which may have reduced PCA for other oxides. The relative Staphylococcus aureus attachment to each oxide was also assessed. The CPTi and TiMo-αβ oxides showed significantly reduced S. aureus attachment after 1 h of UVA compared to un-anodized CPTi. Cell culture results verified that the UVA irradiation did not negatively influence the MC3T3-E1 attachment or proliferation on the mixed-phase oxides.

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Section: Oxide Surface Characterizationmentioning

confidence: 96%

Section: Oxide Surface Characterizationmentioning

confidence: 99%

Photocatalytic Activity and Antibacterial Properties of Mixed-Phase Oxides on Titanium Implant Alloy Substrates

Johnson,

Donaho,

Ali

et al. 2024

Coatings

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“…Furthermore, monodispersed PDA NPs have much greater surface areas than the other surfaces and contributed to the interlocked con guration of cells. [51][52][53][54] 5 Conclusion…”

Section: Cell Viability and Proliferation Ability Assays Various Scaf...mentioning

confidence: 99%

Novel Fabrication of Self-healing Chitosan/Alginate porous Hydrogels with Adhesive Dopamine chemistry – based materials for improve Therapeutic Potential in Femoral Fractures

Ouyang,

Li,

Yang

et al. 2024

Preprint

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This study explores the significant impact of Polydopamine nanospheres (PDA NPs) on polymer properties, ascribed to the physical and chemical interactions between the PDA and natural polymers. It also demonstrated the PDA’s ability to modify porous structure and enhance the mechanical characteristics of Chitosan/alginate (Ch/Alg) hydrogel nanocomposites for tissue engineering scaffolds. The porous scaffold with nano surface morphology, hierarchical pore structure, appropriate porosity and superior bio-mechanical strength was successfully synthesized. The hierarchical pore structure of the synthesized PDA modified Ch/Alg-DA hydrogel based scaffolds is favorable for cell ingrowth and cell adhesion. In loading and release experiments, Ch/Alg-DA/PDA hydrogels/scaffolds were confirmed to have better adsorption ability to Ciprofloxacin (CFLX) and more steady in vitro release behavior than the other hydrogels. Osteoblast cells were cultured on the surfaces of the scaffolds for up to 3 days, and proliferation and cell viability were examined using fluorescence microscopy, Moreover, the PDA loaded Ch/Ag-DA can improve the adhesion and promote the proliferation and spontaneous growth of osteoblast cells. Even though, further research is necessary to understand all the parameters affecting biocompatibility, the as prepared Ch/Ag-DA/ PDA NPs may signified an idealistic tool for the treatment of bone deficiency and regeneration of bone tissue, among other applications.

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“…9 Among them, TiNWs are particularly interesting because of a typical nanofibrous feature, ultrathin diameter, large specific surface area, and good biocompatibility. 10,11 Compared with the nanofibrous polymers, TiNWs have more stable size and morphology under aqueous solution because they have no swelling behavior. In addition, TiNWs could be easily synthesized by means of a simple hydrothermal route.…”

Section: Introductionmentioning

confidence: 99%

“…Different types of titania materials have been synthesized, including titania nanoparticles (TiNPs), 6 titania nanotubes, 7 titania electrospun nanofibers, 8 and titania nanowires (TiNWs) 9 . Among them, TiNWs are particularly interesting because of a typical nanofibrous feature, ultrathin diameter, large specific surface area, and good biocompatibility 10,11 . Compared with the nanofibrous polymers, TiNWs have more stable size and morphology under aqueous solution because they have no swelling behavior.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of nanofibrous and hollow titania microspheres as drug‐laden cell carriers

Bai

Wang

Chen

et al. 2023

Int J Applied Ceramic Tech

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Microspheres are one type of promising cell‐supporting matrices. However, the synthesis of nanofibrous and hollow microspheres as drug‐laden cell carriers is still a great challenge. Here, the nanofibrous and hollow titania nanowire (NH‐TiNW) microspheres were synthesized by in situ alkali hydrothermal treatment of hollow titania (H‐Ti) microspheres, and their microstructure, biocompatibility, and drug delivery property were evaluated. By controlling hydrothermal temperature from 80 to 120°C and hydrothermal time from 1 to 4 h, the surface of H‐Ti microspheres was controllably tailored with nanoparticles and NWs. The results showed that NH‐TiNW microspheres were spherical in morphology with a diameter of 100–200 µm, hierarchically assembled by numerous TiNWs with the diameter of 10–20 nm, and possessed a nanofibrous and hollow structure. In vitro biocompatibility evaluation showed that NH‐TiNW microspheres presented an enhanced cell attachment and proliferation compared with H‐Ti microspheres due to the presence of the nanofibrous surface. Drug delivery evaluation showed that NH‐TiNW microspheres strongly adsorbed tetracycline hydrochloride (one type of antibiotic, model drug) with a loading efficiency of 81.5% ± 1% due to the presence of the nanofibrous and hollow structure and also effectively maintained the biological efficiency of the loaded drugs to inhibit the growth of bacteria.

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Proliferation of osteoblast precursor cells on the surface of TiO2 nanowires anodically grown on a β-type biomedical titanium alloy

Cited by 6 publications

References 31 publications

Photocatalytic Activity and Antibacterial Properties of Mixed-Phase Oxides on Titanium Implant Alloy Substrates

Photocatalytic Activity and Antibacterial Properties of Mixed-Phase Oxides on Titanium Implant Alloy Substrates

Novel Fabrication of Self-healing Chitosan/Alginate porous Hydrogels with Adhesive Dopamine chemistry – based materials for improve Therapeutic Potential in Femoral Fractures

Facile synthesis of nanofibrous and hollow titania microspheres as drug‐laden cell carriers

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