Abstract:The increase of PFC per spleen and the development of hemolytic foci were examined to clarify the patterns of clonal expansion of B‐lymphocytes in athymic nude mice (nu/nu) and normal littermates (nu/+) subjected to the procedure for antigenic competition between horse erythrocytes (HRBC) and sheep erythrocytes (SRBC). In normal littermates without pretreatment with HRBC, a small number of PFC and hemolytic foci of small size were detected 2 days after the challenge with SRBC. The number of PFC increased progr… Show more
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