“…Other polymeric materials, such as poly (methyl methacrylate) (PMMA), polycarbonate (PC) and polystyrene (PS) are also biocompatible materials for microdevice substrates [52,53]. Over the recent decades, numerous polymer-based devices have been designed and fabricated for microfluidic cell cultures, with different structural features, such as microchannels [5,13,19,47,54-58], micro-wells [3,11,59], micropillars [10,14,17,18,20,60-63] and cell retention chambers. Most of them were designed to optimize medium flow and oxygen perfusion throughout the cell culture and diminish the effect of medium-starved necrotic regions.…”