Proliferating Trichilemmal Tumors

Satyaprakash, Anita; Sheehan, Daniel J.; Sangüeza, Omar P.

doi:10.1097/00042728-200709000-00011

Cited by 8 publications

(7 citation statements)

References 44 publications

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“…More than 90% of cases are located on the scalp. PTT usually appears as a solitary, slow-growing, exophytic lesion, 2-25 cm in size, before a rapid increase in the lesion's size, which can be a sign of malignancy [35]. Proliferating trichilemmal tumors are rare lesions whose histologic hallmark is the presence of trichilemmal keratinization (Figure 3(B1-B3)).…”

Section: Proliferating Trichilemmal Tumormentioning

confidence: 99%

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation

Płachta

Kleibert

Czarnecka

et al. 2021

IJMS

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Neoplasms derived from follicular tissue are extremely rare. Clinically, they are reported as non-symptomatic, slow-growing nodules. These lesions are mainly benign, but the malignant type can occur. Mainly middle-aged people (50–60 years of age) are affected. These carcinomas are mainly localized on the head and neck or torso. They can be locally aggressive and infiltrate surrounding tissue and metastasize to regional lymph nodes. In the minority of cases, distant metastases are diagnosed. Quick and relevant diagnosis is the basis of a treatment for all types of tumors. The patient’s life expectancy depends on multiple prognostic factors, including the primary tumor size and its mitotic count. Patients should be referred to a specialized skin cancer center to receive optimal multidisciplinary treatment. This article tries to summarize all the information that is currently available about pathogenesis, diagnosis, and treatment methods of follicular tumors.

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Section: Proliferating Trichilemmal Tumormentioning

confidence: 99%

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation

Płachta

Kleibert

Czarnecka

et al. 2021

IJMS

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“…Proliferating trichiilemmal tumour (PTT) was described in 1966, accounting for 2% of the TC, and has been initially considered a variant of these trichilemmal cysts [4,5]. This tumour has been described under different denominations, but PTT is the currently accepted term [4,6]. PTTs are defined histologically by an endophytic proliferation, sometimes with a lobulated pattern, giving a multiloculated or solid aspect [4].…”

Section: Introductionmentioning

confidence: 99%

“…This tumour has been described under different denominations, but PTT is the currently accepted term [4,6]. PTTs are defined histologically by an endophytic proliferation, sometimes with a lobulated pattern, giving a multiloculated or solid aspect [4]. They have a homogenous keratinization, lacking a defined granular layer, similar to TCs.…”

Section: Introductionmentioning

confidence: 99%

“…They have a homogenous keratinization, lacking a defined granular layer, similar to TCs. Calcification is a common finding [4,7]. As the TCs, the PTTs are usually located in the scalp, have slight predilection for females and have a variable size, ranging from very small lesions to giant tumours [4].…”

Section: Introductionmentioning

confidence: 99%

“…Calcification is a common finding [4,7]. As the TCs, the PTTs are usually located in the scalp, have slight predilection for females and have a variable size, ranging from very small lesions to giant tumours [4]. Although they were proposed to develop from TC [4], recent studies propose a de novo genesis [8].…”

Section: Introductionmentioning

confidence: 99%

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TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

et al. 2021

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Proliferating trichilemmal tumours (PTT) are defined by a benign squamous cell proliferation inside a trichilemmal cystic (TC) cavity. A possible explanation of this proliferative phenomenon within the cyst may be molecular alterations in genes associated to cell proliferation, which can be induced by ultraviolet radiation. Among other genes, alterations on TP53 and DNA mismatch repair proteins (MMR) may be involved in the cellular proliferation observed in PTT. Based on this assumption, but also taking into account the close relationship between the sebaceous ducts and the external root sheath where TC develop, a MMR, a p53 expression assessment and a TP53 study were performed in a series of 5 PTT cases, including a giant one. We failed to demonstrate a MMR disorder on studied PTT, but we agree with previous results suggesting increased p53 expression in these tumours, particularly in proliferative areas. TP53 alteration was confirmed with FISH technique, demonstrating TP53 deletion in most cells.

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An unusual case of co-localization of proliferating trichilemmal tumor and seborrheic keratosis

Lakhani

Khullar

Sharma

2021

IJDVL

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Proliferating Trichilemmal Tumors

Cited by 8 publications

References 44 publications

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation

TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

An unusual case of co-localization of proliferating trichilemmal tumor and seborrheic keratosis

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