Proliferating Cell Nuclear Antigen in Endometrial Carcinoma: Pretreatment Identification of High-Risk Patients

Endometrial carcinoma: immunohistochemically detected proliferation index is a prognosticator of long-term outcome

“…This correlation is independent from the other factors associated with high proliferation rate, such as high grade and tumour stage, and it remains significant when multivariate Cox regression analysis is applied. This is in keeping with studies by Garzetti et al 23 and Geisler et al, 24 who found a significant correlation of expression of proliferation associated antigens (proliferating cell nuclear antigen (PCNA) and MIB-1) with recurrence free survival. Contrasting results were found by Hamel et al using computerised image analysis of PCNA immunostained cells.…”

Co‐expression of vascular endothelial growth factor and thymidine phosphorylase in endometrial cancer

“…However, we found that VEGF/TP expression and microvessel count had no prognostic value in patients with endometrial cancer. On the other hand, a high PCNA index and p53 expression, which were found to be unfavorable prognostic factors (23,24), significantly correlated with a worse prognosis in univariate analysis. In addition, the multivariate analysis demonstrated that only C Acta Obstet Gynecol Scand 78 (1999) PCNA index remained to be significant for prognosis.…”

“…The microvessel count is expressed as the mean number of vessels in these areas (3). The PCNA index was determined by counting at least 1000 cancer cells, expressed as a percentage of positive nuclear cells (23). For microvessel count and PCNA index, we used the median value as the cutoff point to divide tumor patients into two groups.…”

Clinical value of new techniques of gynecological tumor assessment

“…In endometrial adenocarcinomas the PCNA index has been found to correlatewith tumor grade, depth of myometrial invasion, and recurrence risk (97), and it has beensuggested that PCNA staining can be used as a method of pre‐operativeidentification of high risk patients(98). Ki‐67expression in endometrial carcinomas was found to becorrelated with grade but not with stage or depth of myometrial invasion in onestudy(99), but it emerged as a highly significantindicator of tumor recurrence in another(100).…”