Prolactin stimulation of prolactin receptors in rat liver

Costlow, Mark E.; Buschow, Robert A.; McGuire, William

doi:10.1016/0024-3205(75)90167-8

Cited by 94 publications

(16 citation statements)

References 9 publications

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“…It was found that this receptor was present in much higher concentrations in female than male rats. These findings have been confirmed by other groups including our own (71)(72)(73)(74). The development of these receptors has been shown to follow that of the steroid-metabolizing enzymes rather closely.…”

Section: Central Control Of Prolactin (Pri) Receptors In the Liversupporting

confidence: 81%

Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents

Gustafsson¹,

Eneroth²,

Hökfelt³

et al. 1981

Environ Health Perspect

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At birth testicular androgens irreversibly program brain centers involved in hypothalamopituitary control of hepatic sex-dependent steroid and drug metabolism. This imprinting process results in activation of a hypothalamic "feminostatin"-a secreting center that is turned on just before puberty. Feminostatin inhibits pituitary secretion of "feminizing factor," a pituitary hormone that feminizes the basal type of metabolism characterizing the liver of hypophysectomized and gonadectomized rats. Consequently, female rats that are devoid of feminostatin will secrete feminizing factor from the pituitary, leading to a feminine type of hepatic metabolism. Male rats have an active feminostatin-secreting center, and inhibition of pituitary feminizing factor release results in an autonomous type of liver metabolism. Female rats show a relative androgen unresponsiveness and seem incapable of releasing feminostatin after treatment with natural androgens, possibly because of more efficient metabolism (breakdown) of androgen in the female than in the male rat brain.Frontal deafferentation at the retrochiasmatic and suprachiasmatic level resulted in a complete "feminization" of hepatic steroid metabolism in male rats. Such an effect was also seen when lesions involving mainly the anterior periventricular hypothalamic area and the suprachiasmatic nucleus were performed in male rats. No effects were seen in analogous lesions in female rats in any of the cases studied. These findings suggest that a region including the anterior hypothalamic periventricular area, the suprachiasmatic nucleus and adjacent areas is involved in the control of hepatic steroid metabolism. It is postulated that the neuronal cell bodies that produce feminostatin have their origins in this area of the hypothalamus or may send axons through this area to the basal hypothalamus and thus directly or indirectly influence the anterior pituitary gland.Regulation by the central nervous system of a "lactogenic" (prolactin, Prl) receptor, present in the female rat liver, was also studied. This receptor is present in very low concentration or absent in the male rat. Anterior hypothalamic deafferentation at the retrochiasmatic level in male rats increased the hepatic Prl receptor concentration to the female level 3-4 days following the operation. A transection rostral to the suprachiasmatic nucleus had no effect on the concentration of Prl receptors in male animals. Our results demonstrate that the number of Prl receptors is regulated by the hypothalamo-pituitary system. The receptor-inducing pituitary factor might be related to the feminizing factor. Experiments were carried out to elucidate the nature of the Prl receptor-inducing pituitary factor. April 1981 129Human growth hormone (hGH) continuously administered was shown to induce Prl receptors in livers from male and female hypophysectomized-gonadectomized rats. The prolactin receptors were increased to a level found in control female rat livers. This inductive effect of hGH was also seen in adrenalectomized and...

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Section: Central Control Of Prolactin (Pri) Receptors In the Liversupporting

confidence: 81%

Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents

Gustafsson¹,

Eneroth²,

Hökfelt³

et al. 1981

Environ Health Perspect

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“…It is reported that prolactin modifies its own receptor in the liver and mammary tumors in rats (Costlow et al, 1975a(Costlow et al, , b, 1976Holdaway and Friesen, 1976;Posner et al, 1974 and. However, no close relations between plasma prolactin levels and binding seen in the present study would indicate that the change in prolactin levels in the circulation near parturition is not so great as to alter prolactin receptor as suggested previously …”

contrasting

confidence: 52%

“…The mammary tumors are clearly different from normal glands in prolactin binding as well as in the other characteristics, while the former still retains some characteristics of the latter. They further suggest that the presence of prolactin binding sites may not always predict directly the responsiveness to prolactin of pregnancy-dependent mammary tumors as observed in 7, 12-dimethylbenz [a] anthracene (DMBA)-induced, prolactin dependent mammary tumors in rats (Costlow et al, 1976;D. Sombre et al, 1976;Smith et al, 1976).…”

mentioning

confidence: 99%

Prolactin binding in pregnancy-dependent mammary tumors in GR/A mice.

Yanai

Nagasawa

1978

Endocrinol Japon

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“…We (Costlow et al, 1975), soit dans la glande mammaire (Djianeet Durand, 1977).Récemment nous avons développé des techniques de désaturation des récepteurs prolactiniques soit in vivo , soit in vitro (Kelly et al,1979). La désatu-ration in vitro utilise les agents chaotropiques à forte molarité (MgCl, 4M) et permet la mesure du nombre total de récepteurs, les libres et ceux saturés par l'hormone endogène.…”

unclassified

“…Dans la glande mammaire, le récepteur a été isolé et purifié (Shiu et Friesen, 1974). Les modulations hormonales du nombre de récepteurs ont été largement étudiées dans le foie (Posner et al, 19746 ;Costlow et al, 1975) et la glande mammaire : Contrairement à la majorité des hormones étudiées (Insuline, GH, LH), pour lesquelles on a mis en évidence une régulation négative du nombre de récepteurs par leur hormone spécifique (« down regulation »), on a reconnu à la prolactine un effet stimulant de son propre récepteur soit dans le foie (Costlow et al, 1975), soit dans la glande mammaire (Djianeet Durand, 1977).…”

unclassified

Effet à court terme de la prolactine sur son récepteur

Djiane¹,

Delouis²,

Kelly³

et al. 1980

Reprod. Nutr. Dévelop.

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It is known that prolactin (PRL) when injected chronically is able to increase the level of its own receptors. We (Costlow et al., 1975), soit dans la glande mammaire (Djianeet Durand, 1977).Récemment nous avons développé des techniques de désaturation des récepteurs prolactiniques soit in vivo , soit in vitro (Kelly et al.,1979). La désatu-ration in vitro utilise les agents chaotropiques à forte molarité (MgCl, 4M) et permet la mesure du nombre total de récepteurs, les libres et ceux saturés par l'hormone endogène.

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Prolactin stimulation of prolactin receptors in rat liver

Cited by 94 publications

References 9 publications

Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents

Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents

Prolactin binding in pregnancy-dependent mammary tumors in GR/A mice.

Effet à court terme de la prolactine sur son récepteur

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