Prolactin Status in Experimentally Induced Acute Renal Failure in the Rat

Dobbie, James W.; Mountjoy, Kathleen G.; Ea, Cowden; Allison, M E; Ratcliffe, John G.

doi:10.1159/000182078

Cited by 6 publications

(5 citation statements)

References 13 publications

(13 reference statements)

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“…197-199] have examined the distribu tion and properties of renal prolactin receptors throughout a series of vertebrates, and conclude that both the prolactins and their receptors have undergone considerable change. Receptor abundance can also vary throughout life; there is an increase in renal prolactin receptor abundance during early development and metamorphosis of the bullfrog R. catesbeiana [25,199], Prolactin responsiveness may be al tered in some clinical conditions, such as the decrease in renal prolactin binding during acute renal failure in the rat [36]. …”

mentioning

confidence: 99%

Prolactin and Osmoregulation in Vertebrates

Loretz

Bern²

1982

Neuroendocrinology

172

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Studies on the roles of prolactin in vertebrate osmoregulation have expanded in recent years to include examination of ionic and osmotic factors contributing to the regulation of secretion by paraneuronal prolactin-secreting cells and the effects of prolactin on a number of ion- and water-transporting epithelial tissues. Coupled with information on whole-animal homeostatic effects, the application of surgical, tissue-culture, biophysical and biochemical techniques to individual components will facilitate broader and more integrated functional analyses of the important osmoregulatory effects of this hormone in all vertebrate classes.

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mentioning

confidence: 99%

Prolactin and Osmoregulation in Vertebrates

Loretz

Bern²

1982

Neuroendocrinology

172

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“…Serum prolactin, urea and creatinine and prolactin receptors in kidney and liver were assayed as previously described [2], Histology. Paraffin sections stained with haemotoxylin and eosin were prepared front sample blocks of the kidneys from each animal.…”

Section: Methodsmentioning

confidence: 99%

“…Since we have demonstrated increased circulating pro lactin and decreased renal binding of this hormone in exper imentally induced acute renal failure [2], it was considered that assessment of endogenous prolactin status in animals with a spontaneously occurring, apparently prolactin-sen sitive nephropathy might contribute to understanding the aetiological mechanisms causing deranged prolactin status in renal disease.…”

Section: Introductionmentioning

confidence: 99%

Prolactin Status in Chronic Nephropathy in the Rat

Cowden¹,

Dobbie²,

Mountjoy³

et al. 1981

Nephron

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Decreased specific prolactin binding to kidney membrane preparations, and an upward trend in serum prolactin levels were observed concomitantly with the onset of chronic progressive nephropathy in male rats of the OFA Sandoz SPF strain. Females of the same strain developed a less severe form of the disease at a later age, but failed to show the changes in prolactin status seen in male rats. Nephropathy in both male and female animals was associated with morphological abnormalities of a predominantly tubular nature, but was not associated with development of renal failure as indicated by serum urea and creatinine levels. Possible mechanisms for the observed alterations in prolactin status are discussed.

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“…In an acute renal failure model, the serum concentration of PRL was increased, but not PRL binding. This may indicate that the hormone changes that respond to a kidney injury [181]. Furthermore, hyperprolactinemia is attributed to increased PRL secretion and decreased clearance due to tissue injury [182,183].…”

Section: Influence Of Prolactin In Kidney Function and Diseasementioning

confidence: 99%

Sex Differences in Renal Function: Participation of Gonadal Hormones and Prolactin

2021

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Kidney pathophysiology is influenced by gender. Evidence suggests that kidney damage is more severe in males than in females and that sexual hormones contribute to this. Elevated prolactin concentration is common in renal impairment patients and is associated with an unfavorable prognosis. However, PRL is involved in the osmoregulatory process and promotes endothelial proliferation, dilatation, and permeability in blood vessels. Several proteinases cleavage its structure, forming vasoinhibins. These fragments have antagonistic PRL effects on endothelium and might be associated with renal endothelial dysfunction, but its role in the kidneys has not been enough investigated. Therefore, the purpose of this review is to describe the influence of sexual dimorphism and gonadal hormones on kidney damage, emphasizing the role of the hormone prolactin and its cleavage products, the vasoinhibins.

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Prolactin Status in Experimentally Induced Acute Renal Failure in the Rat

Cited by 6 publications

References 13 publications

Prolactin and Osmoregulation in Vertebrates

Prolactin and Osmoregulation in Vertebrates

Prolactin Status in Chronic Nephropathy in the Rat

Sex Differences in Renal Function: Participation of Gonadal Hormones and Prolactin

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