Prolactin response to low dose sulpiride.

McMurdo, Marion E. T.; Howie, P. W.; Lewis, Mark; Marnie, M.; McEwen, John; McNeilly, Alan S.

doi:10.1111/j.1365-2125.1987.tb03153.x

Cited by 13 publications

(6 citation statements)

References 12 publications

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“…The peak plasma prolactin levels (Cmax,PRL) have been reported to be dose-related up to a maximal release following administration of remoxipride [13,14,29], sulpiride [16,[21][22][23][24][25] and also following TRH [26,27]. Maximal prolactin peak concentrations are expected to be achieved with the doses of remoxipride and TRH administered in the present study [26,27].…”

Section: Introductionmentioning

confidence: 59%

Influence of the dosing interval on prolactin release after remoxipride.

Movin-Osswald¹,

Hammarlund‐Udenaes²,

Bahr³

et al. 1995

Brit J Clinical Pharma

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1 The prolactin response following administration of the D2-dopamine receptor antagonist remoxipride was studied in eight healthy male volunteers. correspond to a maximal release of prolactin according to earlier studies. A small second peak of prolactin was observed after 2 h. The release was gradually increased with longer time intervals between the consecutive doses. The refractory period for a second prolactin release similar to the first one after remoxipride was found to be 24 h for most of the subjects. 3 TRH resulted in a faster and higher increase in prolactin response of a shorter duration than after remoxipride administered 2 h after the first dose.

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Section: Introductionmentioning

confidence: 59%

Influence of the dosing interval on prolactin release after remoxipride.

Movin-Osswald¹,

Hammarlund‐Udenaes²,

Bahr³

et al. 1995

Brit J Clinical Pharma

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“…As with other central antidopaminergic drugs, levosulpiride can antagonize the inhibition of dopamine on the prolactin producing cells of the anterior pituitary, thus inducing a hypersecretioin of prolactin 5 ) . However, in humans, this effect is not dose-dependent, but rather seems to be reduced after chronic treatment 24 ) and in most cases it does not induce clinical symptoms of hyperprolactinemia.…”

Section: Discussionmentioning

confidence: 99%

Effects of Levosulpiride in Patients with Functional Dyspepsia Accompanied by Delayed Gastric Emptying

Song¹,

Chun²,

Kim³

et al. 1998

Korean J Intern Med

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ObjectivesLevosulpiride is the levo-enantiomer of sulpiride, a well-known antiemetic, antidyspeptic and antipsychotic drug. This study was undertaken to investigate the effects of levosulpiride on dyspeptic symptoms and gastric motor function in a group of patients with functional dyspepsia showing delayed gastric emptying.MethodForty two eligible patients were entered into a 3 week, double-blind randomized comparison of 25mg of levosulpiride or placebo t.i.d.. Symptom assessment and gastric scintigraphy following the intake of scrambled egg sandwich, were performed in each patient before and after treatment.ResultsThe improvement of symptom score in levosulpiride group was higher than the placebo group (p<0.05). We assessed global efficacy, which was excellent in 1 (6%), good 11 (65%), fair 4 (24%), nil 1 (6%) of those receiving levosulpiride, and fair 9(60%), nil 5 (33%), poor 1 (6%) of those receiving placebo. Levosulpiride tended to be more effective than placebo in relieving the dyspeptic symptoms especially in the subgroups of dysmotility-like (p<0.05) and nonspecific (p<0.05) as compared to other subgroups (p=0.16). The reduction of gastric emptying time after levosulpiride treatment was more marked than Placebo group (p<0.05). We found a significant correlation between changes of symptom score and gastric emptying time (r=0.47, p=0.01. No serious adverse effects were reported after administration of either levosulpiride or placebo. Only two patients reported mild somnolence during levosulpiride administration.ConclusionsLevosulpiride is effective and well tolerated in patients with functional dyspepsia accompanied by delayed gastric emptying. Its efficacy may be related to its action on the gastric motor function by improving the delayed gastric emptying.

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“…In a large, multicenter, double-blind, placebo-controlled trial investigating the drug treatment of dyspepsia, 408 patients were treated with oral levosulpiride 25 mg three times daily for 1 month, and 7 % of the female patients receiving levosulpiride had hyperprolactinemia and related symptoms [12]. However, symptoms such as galactorrhea and breast pain have been found to be decreased with the chronic use of levosulpiride [13,14]. We therefore suspect that domperidone with concomitant levosulpiride on admission for radioiodine therapy may have promoted the breast-related symptoms.…”

Section: Discussionmentioning

confidence: 99%