Prolactin opens the sensitive period for androgen regulation of a larynx-specific myosin heavy chain gene

Edwards, Christofer J.; Yamamoto, Kazutoshi; Kikuyama, Sakaé; Kelley, Darcy B.

doi:10.1002/(sici)1097-4695(199912)41:4<443::aid-neu1>3.0.co;2-6

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…Thus, these outcomes reveal previously undescribed complexities in the relationships between PRL and men's mating effort, showing some broad commonalities with findings in certain other taxa (Rubin and Specker, 1992;Edwards et al, 1999;Leonard and Ferkin, 1999;Iwata et al, 2000;Preault et al, 2005;Toyoda et al, 2005). Our results are generally consistent with findings from various bird and mammalian species showing that fathers who cooperate with mothers to raise young have elevated PRL.…”

Section: Discussionsupporting

confidence: 87%

Prolactin, fatherhood, and reproductive behavior in human males

Gettler

McDade

Feranil

et al. 2012

American J Phys Anthropol

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Although humans are considered unusual among mammals for the intensity of care that fathers often provide offspring, little is known about the hormonal architecture regulating human paternal investment. Prolactin has important reproductive functions in both female and male mammals and other taxa, making it a candidate regulator of human paternal behavior. Notably, prolactin is higher during periods of offspring care in some species, but it is unknown if this pattern occurs in human fathers. We draw on a sample of men (n = 289; age 21-23 at baseline) from Metropolitan Cebu City, Philippines to evaluate relationships between prolactin, assayed from dried blood spots, and components of reproductive behavior and relationship status. In this sample, fathers had higher prolactin than nonfathers (P = 0.006), and fathers of infants had borderline higher prolactin than fathers of older children (P = 0.054). Among single nonfathers at baseline (2005), baseline prolactin did not predict who transitioned to fatherhood by follow-up 4.5 years later. Among nonfathers, men with greater prolactin reported more lifetime sexual partners (P = 0.050) as well as more sexual activity in the month before sampling (P = 0.060). Our results suggest that fathers in Cebu have higher prolactin than nonfathers, with hormone levels highest among fathers of young infants. Although these findings are generally consistent with evidence from other species for pronurturing effects of prolactin, evidence for positive relationships between the hormone and measures of sexual behavior at Cebu point to likely complexities in the hormone's involvement in male reproductive strategy.

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Section: Discussionsupporting

confidence: 87%

Prolactin, fatherhood, and reproductive behavior in human males

Gettler

McDade

Feranil

et al. 2012

American J Phys Anthropol

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“…In X. laevis, xlMyHC-LM is expressed in the adult larynx but not in embryos (Edwards et al 1999), a completely different pattern of expression from that of its X. tropicalis ortholog. Phylogenetic analysis indicates that xtMyHC-101d and xtMyHC-101c were both present before xlMyHC-LM (Fig.…”

Section: Xtmyhc-101c Rather Than 101d Is Closer To X Laevis Xlmyhc-lmentioning

confidence: 95%

Sexually differentiated, androgen-regulated, larynx-specific myosin heavy-chain isoforms in Xenopus tropicalis; comparison to Xenopus laevis

2008

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We have shown that the sarcoplasmic myosin heavy-chain (MyHC) isoform xtMyHC-101d is highly and specifically expressed in the larynx of the aquatic anuran, Xenopus tropicalis. In male larynges, the predominant MyHC isoform is xtMyHC-101d, while in females, another isoform, xtMyHC-270c, predominates. The X. tropicalis genome has been sequenced in its entirety, and xtMyHC-101d is part of a specific array of xtMyHC genes expressed otherwise in embryonic muscles. The administration of the androgen dihydrotestosterone increases the expression of xtMyHC-101d in juvenile larynges of both sexes. Using ATPase histochemistry, we found that in adults, X. tropicalis male laryngeal muscle contains only fast-twitch fibers, while the female laryngeal muscle contains a mix of fastand slow-twitch fibers. Juvenile larynges are female-like in fiber type composition (44% slow twitch, 56% fast twitch); androgen treatment increases the percentage of fast-twitch fibers to 86%. xtMyHC-101d predominates in larynges of dihydrotestosterone-treated juveniles but not in larynges of untreated juveniles. We compared the larynx-specific expression of xtMyHC genes in X. tropicalis to the MyHC gene expressed in X. laevis larynx (xlMyHC-LM) by sequencing the entire xlMyHC-LM gene. The androgen-regulated xtMyHC that predominates in the male larynx of X. tropicalis is not the gene phylogenetically most similar to xlMyHC-LM at the nucleotide level but is instead a similar isoform found in the same MyHC array and expressed in the embryonic muscle.

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“…Two certified breeding pairs of adult [15,22,39,40] and on information on SSRI and endocrine interactions [19][20][21]. CRF 5 corticotropin-releasing factor; TRH 5 thyrotropin-releasing hormone; TSH 5 thyroid-stimulating hormone; ACTH 5 adrenocorticotropic hormone; PRL 5 prolactin; TH 5 thyroid hormones T 3 and T 4 . frogs (Xenopus laevis) were obtained from Carolina Biological Supply Company.…”

Section: Frog Breedingmentioning

confidence: 99%

Growth and development of tadpoles (Xenopus laevis) exposed to selective serotonin reuptake inhibitors, fluoxetine and sertraline, throughout metamorphosis

Conners

Rogers

Armbrust

et al. 2009

Enviro Toxic and Chemistry

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Abstract-Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed drugs that are present in sewage effluents and surface waters. The objective of the present study was to determine whether low environmentally relevant concentrations of the SSRIs fluoxetine and sertraline could impair growth and development in tadpoles of the African clawed frog (Xenopus laevis) and to evaluate if such effects may be caused by a disruption of the neuroendocrine system. Tadpoles were exposed to SSRIs at concentrations of 0.1, 1, and 10 mg/L for 70 d throughout metamorphosis. No effects on deformities were observed. Tadpoles exposed to fluoxetine (10 mg/L) and sertraline (0.1, 1, and 10 mg/L) exhibited reduced growth at metamorphosis. Tadpoles exposed to sertraline (0.1 and 1 mg/L) exhibited an acceleration of development as indicated by an increase in the time to tail resorption. The effects of SSRIs on growth and development in tadpoles were likely driven by reduced food intake. Reduced feeding rates were observed in SSRI-exposed tadpoles, and nutritional status can influence growth and development in amphibians via effects on the neuroendocrine system. Only sertraline was capable of causing developmental toxicity in tadpoles at environmentally relevant concentrations. These data warrant additional research to characterize the risks to human health and wildlife from pharmaceutical exposures.

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Prolactin opens the sensitive period for androgen regulation of a larynx-specific myosin heavy chain gene

Cited by 13 publications

References 34 publications

Prolactin, fatherhood, and reproductive behavior in human males

Prolactin, fatherhood, and reproductive behavior in human males

Sexually differentiated, androgen-regulated, larynx-specific myosin heavy-chain isoforms in Xenopus tropicalis; comparison to Xenopus laevis

Growth and development of tadpoles (Xenopus laevis) exposed to selective serotonin reuptake inhibitors, fluoxetine and sertraline, throughout metamorphosis

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