Prolactin inhibits oocyte release after gonadotropin stimulation in the rat: Putative mechanism involving ovarian production of beta-endorphin and prostaglandin

Polisseni, Fernanda; Faletti, A.; Pereira, Virginia M.; Reis, Adelina M.; Camargos, Aroldo F.; Reis, Fernando M.

doi:10.1016/j.fertnstert.2004.07.981

Cited by 8 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRL also stimulated PG release from isolated hamster Leydig cells. In agreement with our findings in hamster testes, PRL regulation of PG production has also been described in rodent liver, ovary, uterus and carrageenan-induced pleurisy (Dave et al, 1982;Meli et al, 1993;Prigent-Tessier et al, 1996;Polisseni et al, 2005).…”

Section: Discussionsupporting

confidence: 93%

Prolactin (PRL) induction of cyclooxygenase 2 (COX2) expression and prostaglandin (PG) production in hamster Leydig cells

Matzkin¹,

Ambao²,

Carino³

et al. 2012

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

Prolactin (PRL) induction of cyclooxygenase 2 (COX2) expression and prostaglandin (PG) production in hamster Leydig cells

Matzkin¹,

Ambao²,

Carino³

et al. 2012

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

“…Fernanda Polisseni et al suggested that the inhibitory effect of PRL on ovarian prostaglandin release may not involve the NO pathway, as no change was induced either on NO synthase activity or NO metabolite accumulation in PRL treated ovaries (29). In infertility due to both partners a positive correlation was observed between nitrite and prolactin.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative stress, antioxidants and prolactin in infertile women

Veena

Upadhya

Adiga

et al. 2008

Indian J Clin Biochem

View full text Add to dashboard Cite

The objective of the study was to estimate the serum concentrations of oxidative stress markers-lipid hydroperoxide (MDA-Malondialdehyde), lactate dehydrogenase (LDH), nitrite; and ferric reducing antioxidant power (FRAP) - a measure of total antioxidant capacity in serum. Serum nitrite levels were high in fertile women than in infertile women (p<0.001), whereas MDA was high in infertile women than in fertile group (p<0.018). On classifying the entire group of women with infertility based on the etiology, serum MDA and LDH levels were higher in women with infertility due to unexplained factor than in women with other causes contributing to infertility compared to controls (p<0.001, p<0.02). A positive correlation among serum prolactin and nitrite suggested that hyperprolactinemia could contribute to infertility by inducing oxidative damage. Serum FRAP levels showed no significant difference in the groups studied. Lipid peroxidation was high in women with unexplained infertility which may be due to hyperprolactinemia.

show abstract

“…The presence of b-end in the follicular fluid is reported and its concentration varies in relation to cycle stage and ovarian stimulation regimens (Petraglia et al, 1985;Aleem et al, 1987;Facchinetti et al, 1988Facchinetti et al, , 1989Kaminski et al, 2000; review by Kaminski et al, 2003). b-Endorphin is known to play a role in regulating follicular development (Hamada et al, 1995) and in inhibiting oocyte maturation (O, 1990;Dell'Aquila et al, 2002), progesterone secretion by granulosa cells (GC; Gregoraszczuk and Slomczynska, 1998), ovulation and prostaglandin synthesis (Faletti et al, 1995;Faletti et al, 2003;Polisseni et al, 2005). However, the importance of b-end in the ovarian physiology remains a matter of active debate.…”

Section: Introductionmentioning

confidence: 99%

Expression and localization of the µ‐opioid receptor (MOR) in the equine cumulus–oocyte complex and its involvement in the seasonal regulation of oocyte meiotic competence

Dell’Aquila

Albrizio

Guaricci

et al. 2008

Molecular Reproduction Devel

View full text Add to dashboard Cite

The micro-opioid receptor (MOR) was identified in equine oocytes, cumulus and granulosa cells. By RT-PCR, a 441bp fragment was observed. By immunoblotting, a 65 kDa band was detected in samples of winter anestrous whereas in cells recovered in breeding season, two bands, 65 and 50 kDa, were found. The 65 kDa band was significantly more intense in winter anestrous specimens. In samples recovered in the breeding season, this band significantly decreased with the raise of follicle size and was heavier in compact oocytes and cumulus cells. The protein was localized on the oolemma and within the cytoplasm of oocytes and cumulus cells. In vitro oocyte maturation rate (MR), analyzed by confocal microscopy for nuclear chromatin, microfilaments and microtubules, was reduced after the addition of 3 x 10(-8) M beta-endorphin in medium without additional hormones. Inhibitory effects of 10(-3) M Naloxone in oocytes collected in anestrous and spring transition were observed, both in presence and absence of hormones added to culture medium. Increased MRs were observed in oocytes collected in anestrous and cultured in presence of 10(-8) M Naloxone. The exposure to 10(-3) M Naloxone induced significant intracellular calcium increases in cumulus cells recovered all over the year. beta-Endorphin 3 x 10(-8) M induced significant calcium increases only in cumulus cells recovered in fall transition and anestrous. Naloxone 10(-8) M did not induce intracellular calcium modifications. We conclude that the MOR is differentially expressed in equine cumulus-oocyte complexes in the different seasons of the year and plays a role in the seasonal regulation of meiotic competence of equine oocytes.

show abstract

Prolactin inhibits oocyte release after gonadotropin stimulation in the rat: Putative mechanism involving ovarian production of beta-endorphin and prostaglandin

Cited by 8 publications

References 31 publications

Prolactin (PRL) induction of cyclooxygenase 2 (COX2) expression and prostaglandin (PG) production in hamster Leydig cells

Prolactin (PRL) induction of cyclooxygenase 2 (COX2) expression and prostaglandin (PG) production in hamster Leydig cells

Evaluation of oxidative stress, antioxidants and prolactin in infertile women

Expression and localization of the µ‐opioid receptor (MOR) in the equine cumulus–oocyte complex and its involvement in the seasonal regulation of oocyte meiotic competence

Contact Info

Product

Resources

About