Prolactin and thyroid hormone levels are associated with suicide attempts in psychiatric patients

Association between prolactin and thyroid hormones with severity of psychopathology and suicide risk in drug free male schizophrenia

“…Suicidal ideation, which is considered as one of the risk factors for suicide in the schizophrenia case, and is usually not reported [26]. A study by Pompili et al [11] has suggested that prolactin and thyroid hormones may be associated with suicidal behavior. The authors note that in multivariate analysis, higher values of free T3 may be associated with suicide attempts.…”

“…It has been reported that 9%-13% of the schizophrenia patients complete suicide, while 25% make at least one suicide attempt in their lifetime [10]. A previous study has linked abnormalities in thyroid hormones and prolactin levels with suicidal risk in schizophrenia patients [11].…”

Lack of confirmation of thyroid endophenotype in Bipolar Disorder Type I and their first-degree relatives

“…The relevance of the thyroideal and other neuroendocrine biological factors in the outcome of bipolar disorders is relevant. Pompili et al (2012) associated recent suicidal attempts with free triiodothyronine (FT3) and prolactin levels in a naturalistic sample of 439 patients suffering from major depression disorder, bipolar disorder and psychotic disorders. As the authors pointed out, both prolactin and thyroid hormones may be involved in a complex compensatory mechanism to correct reduced central serotonin activity.…”

Prolactin levels in drug-naïve patients with schizophrenia and other psychotic disorders

“…A dysregulation of the serotoninergic system may also contribute to the observed hyperprolactinaemia in antipsychotic na€ ıve patients; prolactin hypersecretion may be part of a complex mechanism whose aim is to compensate the reduced serotoninergic activity (Pompili et al 2012).…”