Prolactin and growth hormone stimulate food intake in ring doves

Buntin, John D.; Figge, Gary R.

doi:10.1016/0091-3057(88)90227-4

Cited by 59 publications

(37 citation statements)

References 54 publications

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“…Peripheral administration had no effects. On the other hand, studies in ring doves demonstrated enhanced food intake and body weight following both peripherally and centrally administered GH [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Intracerebroventricularly and Intraperitoneally Administered Growth Hormone on Body Weight and Food Intake in fa/fa Zucker Rats

et al. 2002

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Growth hormone (GH) possesses multiple metabolic effects, in particular with regard to glucose and lipid homeostasis. Studies on the effects of GH on body weight and food and water intake are scarce and have yielded controversial results. We investigated the effects of different modes of GH administration on the parameters of body weight and food intake as well as on insulin and leptin concentrations in fa/fa Zucker rats. In control experiments, aqua pro injectione was given. GH was administered over a time period of 11 days at a daily dose of 250 µg intraperitoneally (i.p.) and 25 µg intracerebroventricularly (i.c.v.). While both food intake and body weight were found to be unaltered in the four groups after this observation period, there was an enhanced food intake and consecutively an increase in body weight over the day period when compared to the night period in the groups of rats that received GH i.c.v. or i.p. This tendency was also shown for water intake. Insulin and leptin concentrations were similar in all groups. Thus, injection of GH appears to modify food intake-related behavior, since the periods of enhanced food and water intake were shifted from night- to daytime. Thus, while in general the metabolic parameters remained unchanged, the activity pattern was clearly modified.

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Section: Introductionmentioning

confidence: 99%

Effects of Intracerebroventricularly and Intraperitoneally Administered Growth Hormone on Body Weight and Food Intake in fa/fa Zucker Rats

et al. 2002

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“…Intracerebroventricular (icv) injections of PRL dramatically increase food intake in ring doves (31,32), with males showing a greater response than females. Intracerebroventricular injections of PRL have also been shown to reduce plasma luteinizing hormone (LH) levels (33) and to cause gonadal regression in this species (31, 33).…”

mentioning

confidence: 99%

Changes in Feeding Activity, Plasma Luteinizing Hormone, and Testes Weight in Ring Doves Following Hypothalamic Injections of Prolactin

Foreman

Lea

Buntin

1990

J Neuroendocrinology

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Microinjections of ovine prolactin were administered unilaterally to the ventromedial hypothalamic nucleus and the preopticsuprachiasmatic region in adult male ring doves in an attempt to determine the site(s) at which intracranial injections of prolactin act to alter feeding behaviour and gonadotropin secretion in this species. Food intake and body weight were measured daily during a 6-day pretreatment period and the 5-day treatment period that immediately followed. During the treatment period, birds received twice daily injections (0.5 PI) of either 2.5 ng ovine prolactin or saline vehicle. An additional group of birds with cannulae in the ventromedial nucleus were given twice daily injections of 25 ng ovine prolactin. Although food consumption was unaffected by low dose prolactin treatment, birds given 25 ng prolactin injections into the ventromedial nucleus showed a significant augmentation in food intake. Injections of 25 ng prolactin into the preoptic area also increased feeding; however, the magnitude of this hyperphagic response, as expressed relative to pretreatment levels, was less than that observed following prolactin injection into the ventromedial nucleus. No differences were observed between prolactin-treated and vehicle-treated birds in either cannulation group when testes weights and plasma luteinizing hormone concentrations were compared at the end of the treatment period. However, the possibility that prolactin influenced changes in luteinizing hormone and testes weight relative to baseline values could not be assessed due to constraints imposed by the experimental paradigm used. These results suggest that prolactin-sensitive neurons in the ventromedial hypothalamic region and the preoptic area are potential sites of prolactin action in promoting hyperphagia in ring doves. However, the role of these sites in mediating prolactin-induced suppression of gonadotropin secretion in this species remains to be clarified.

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“…Therefore, it might be a possibility that the GHRH-induced GH was related to the anorexigenic effect of GHRH in chicks. In fact, Buntin et al (1988) demonstrated that mammalian GH stimulates feeding behavior in ring doves when administered centrally. However, we could not find the anorexigenic effect after IP injection of bovine GH (Fig.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks

et al. 2015

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Growth hormone-releasing hormone (GHRH), a stimulator of growth hormone (GH) secretion, is known to have several physiological roles such as the regulation of feeding behavior in mammals. Recently, we have reported that central injection of chicken GHRH decreased food intake in chicks, however, its peripheral role on feeding behavior has not been clarified. The purpose of the present study was to investigate the effect of peripheral injection of GHRH on feeding behavior in chicks (Gallus gallus). Intraperitoneal (IP) injection of GHRH47 (1 nmol), full length form of chicken GHRH significantly decreased food intake in chicks although the injection of GHRH27 and GHRH27-NH 2 , short forms of chicken GHRH had no effect. The IP injection of GHRH47 did not induced any abnormal behavior, suggesting that GHRH47-induced anorexia might not be related to abnormal behavior such as sleeping, hyperactivity and convulsion. The anorexigenic effect of GHRH47 seemed not to be related to GH because IP injection of bovine GH did not affect feeding behavior in chicks. Collectively, these results suggest that peripheral GHRH is related to inhibit feeding behavior in chicks.

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Prolactin and growth hormone stimulate food intake in ring doves

Cited by 59 publications

References 54 publications

Effects of Intracerebroventricularly and Intraperitoneally Administered Growth Hormone on Body Weight and Food Intake in fa/fa Zucker Rats

Effects of Intracerebroventricularly and Intraperitoneally Administered Growth Hormone on Body Weight and Food Intake in fa/fa Zucker Rats

Changes in Feeding Activity, Plasma Luteinizing Hormone, and Testes Weight in Ring Doves Following Hypothalamic Injections of Prolactin

Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks

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