Prolactin, a natriuretic hormone, interacting with the renal dopamine system

Ibarra, Fernando; Crambert, Susanne; Eklöf, Ann-Christine; Lundquist, Annika; Hansell, Peter; Holtbäck, Ulla

doi:10.1111/j.1523-1755.2005.00586.x

Cited by 45 publications

(31 citation statements)

References 30 publications

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“…Prolactin is known as a natriuretic hormone which interacts with the renal dopamine system, and its natriuretic response is associated with inhibition of proximal tubular Na,K-ATPase (Ibarra et al, 2005). The location of its receptor in kidney (enriched in medulla and cortex) elucidated in the present study was consistent with the region where the hormone works.…”

Section: Discussionsupporting

confidence: 79%

Comparison of Gene Expression Profiles Among Papilla, Medulla and Cortex in Rat Kidney

et al. 2006

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-The aim of this study was to compare gene expression profiles in the different kidney regions as the basis for toxicogenomics. Rat kidney was separated into papilla, medulla and cortex, and total RNA was isolated from these and from the whole slice. Gene expression profiling was performed using Affymetrix Rat Genome 230 2.0 Array. When global normalization was applied, the expression of β-actin or GAPDH varied among the regions. It was considered that such a comparison could not be made, especially between papilla and other portions, since the production of total mRNA in the former was relatively low. In fact, ANOVA was performed on the gene expression values with global normalization in papilla, medulla, cortex, and whole slice, and the numbers of genes appeared to be the highest in papilla. It was also observed that many genes showed their maximum or minimum in the whole slice, which was theoretically impossible. To overcome the problems associated with global normalization, the "percelome" normalization (a way to obtain the values directly related to the copies of mRNA per cell) was employed to compare the regions. In applying this procedure, probe sets with regional difference in expression were efficiently extracted by ANOVA. When they were sorted by the fold difference to other regions, the higher rank was occupied by genes characteristic of the functions of kidney, i.e., channels, transporters and metabolic enzymes. Some of them were consistent with the literature and were related to pathophysiological phenomena. Comprehensive comparison of data of gene expression in the renal anatomical area will greatly enhance studies of the physiological function and mechanism of toxicity in kidney.

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Section: Discussionsupporting

confidence: 79%

Comparison of Gene Expression Profiles Among Papilla, Medulla and Cortex in Rat Kidney

et al. 2006

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“…Specifically, effects on renal regulation of sodium reabsorption, blood volume 23,24 and interactions with platelet activation 4,25 may have implications in ischaemic heart disease and HF. Earlier reports have claimed an increased frequency of hyperprolactinaemia among patients with HF.…”

Section: Discussionmentioning

confidence: 99%

Serum prolactin and macroprolactin in heart failure: no relation to established laboratory or clinical parameters

Landberg¹,

Dahlström

Alehagen

2010

Ann Clin Biochem

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Background: A few smaller studies have reported that the prolactin concentration is elevated in connection with heart failure. As heart failure is combined with disturbances of several biological systems any or all of which may also influence prolactin concentrations, we wanted to evaluate the relation of prolactin to prognosis in elderly patients. Methods: A total of 462 elderly patients from a primary health-care centre, all with symptoms of heart failure, were included. In addition to clinical examination including echocardiography, concentrations of prolactin, macroprolactin, C-reactive protein, thyroid-stimulating hormone and N-terminal pro B-type natriuretric peptide (NT-proBNP) were measured. Patients were then followed for 10 y, and all incidents of cardiovascular mortality were registered. Results: After excluding patients with macroprolactin, hyperprolactinaemia was found in 3.7% of the patients. There were no differences in prolactin concentrations or in the frequency of macroprolactin between patients with heart failure and those with normal cardiac function, defined as left ventricular ejection fraction of at least 50%. No significant correlation could be found between NT-proBNP and prolactin. Neither could any association be found between cardiovascular mortality and prolactin concentration during 10 y of follow-up. Conclusions: Prolactin concentrations were not associated with cardiovascular mortality or any clinical or biochemical marker of heart failure. Macroprolactin was found in similar frequency among patients with and without heart failure, and showed no correlation with mortality risk.

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“…Two primary functions of PRL in the kidneys are calcium homeostasis (Wongdee & Charoenphandhu 2013) and natriuresis, where PRL inhibits Na C , K C -ATPase activity in the cortex via the renal dopamine system (Ibarra et al 2005). The kidneys are a major site of PRLR expression across species (Buck et al 1992, Nagano & Kelly 1994, Peirce & Chen 2001.…”

Section: Figurementioning

confidence: 99%

“…PRL stimulates the uptake of calcium, which is a major ion in milk, in the small intestine (Jantarajit et al 2007, Ryszka et al 2012 and interacts with the renal dopamine system to effect natriuresis in the kidneys (Ibarra et al 2005). The prepartum surge of PRL that is essential for the subsequent lactation also likely increases blood flow to the mammary gland (MG) at the onset of lactation (Hanwell & Linzell 1973, Peaker 1976, Ota & Peaker 1979, given that PRL increases various measures of cardiac output (Nassar et al 1974, Karmazyn et al 1982.…”

Section: Introductionmentioning

confidence: 99%

Comparative genomics reveals tissue-specific regulation of prolactin receptor gene expression

Schennink¹,

Trott²,

Manjarín³

et al. 2014

Journal of Molecular Endocrinology

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Prolactin (PRL), acting via the PRL receptor (PRLR), controls hundreds of biological processes across a range of species. Endocrine PRL elicits well-documented effects on target tissues such as the mammary glands and reproductive organs in addition to coordinating wholebody homeostasis during states such as lactation or adaptive responses to the environment. While changes in PRLR expression likely facilitates these tissue-specific responses to circulating PRL, the mechanisms regulating this regulation in non-rodent species has received limited attention. We performed a wide-scale analysis of PRLR 5 0 transcriptional regulation in pig tissues. Apart from the abundantly expressed and widely conserved exon 1, we identified alternative splicing of transcripts from an additional nine first exons of the porcine PRLR (pPRLR) gene. Notably, exon 1.5 transcripts were expressed most abundantly in the heart, while expression of exon 1.3-containing transcripts was greatest in the kidneys and small intestine. Expression of exon 1.3 mRNAs within the kidneys was most abundant in the renal cortex, and increased during gestation. A comparative analysis revealed a human homologue to exon 1.3, hE1 N2 , which was also principally transcribed in the kidneys and small intestines, and an exon hE1 N3 was only expressed in the kidneys of humans. Promoter alignment revealed conserved motifs within the proximal promoter upstream of exon 1.3, including putative binding sites for hepatocyte nuclear factor-1 and Sp1. Together, these results highlight the diverse, conserved and tissue-specific regulation of PRLR expression in the targets for PRL, which may function to coordinate complex physiological states such as lactation and osmoregulation.

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Prolactin, a natriuretic hormone, interacting with the renal dopamine system

Abstract: We conclude that prolactin is a natriuretic hormone which interacts with the renal dopamine system for its effects. The natriuretic response is associated with inhibition of proximal tubular Na(+), K(+)-ATPase activity.

Cited by 45 publications

References 30 publications

Comparison of Gene Expression Profiles Among Papilla, Medulla and Cortex in Rat Kidney

Comparison of Gene Expression Profiles Among Papilla, Medulla and Cortex in Rat Kidney

Serum prolactin and macroprolactin in heart failure: no relation to established laboratory or clinical parameters

Comparative genomics reveals tissue-specific regulation of prolactin receptor gene expression

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