Prokinetic effects of
 Citrus reticulata
 and
 Citrus aurantium
 extract with/without
 Bupleurum chinense
 using multistress-induced delayed gastric emptying models

Gong, Yanrong; Liang, Xiaoxia; Dai, Yanting; Huang, Xiang; Su, Qiaozhen; Ma, Yan; Chen, Fenglian; Wang, Shuling

doi:10.1080/13880209.2023.2173249

Cited by 3 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gong et al. have reported similar results that both AuCi and AuCiBup treatment could increase serum 5‐HT, MTL, and SP levels in mice suffering from multistress‐induced delayed gastric emptying (Gong et al., 2023). Likewise, Jung et al.…”

Section: Resultsmentioning

confidence: 74%

“…Notably, there were no significant differences in SP, MTL, 5-HT, and VIP levels observed between the L and FE + SH groups. Gong et al have reported similar results that both AuCi and AuCiBup treatment could increase serum 5-HT, MTL, and SP levels in mice suffering from multistress-induced delayed gastric emptying (Gong et al, 2023). Likewise, Jung et al found that the SP level in Bacillus coagulans SNZ 1969-H group was higher than loperamide group, whereas the VIP level was lower (Jung et al, 2022).…”

Section: Effects On Serum Neurotransmittermentioning

confidence: 77%

See 1 more Smart Citation

Combination of fenchone and sodium hyaluronate ameliorated constipation‐predominant irritable bowel syndrome and underlying mechanisms

Cui,

Hua,

Zou

et al. 2023

Chem Biol Drug Des

View full text Add to dashboard Cite

We sought to explore the protective effect of the combination of fenchone (FE) and sodium hyaluronate (SH) on ice water‐induced IBS‐C rats and the potential mechanism. The neurotransmitter levels, including substance P (SP), motilin (MTL), 5‐hydroxytryptamine (5‐HT), and vasoactive intestinal peptide (VIP), were determined by ELISA methods. The stem cell factors (SCF)/c‐Kit signaling pathway‐related protein and mRNA levels were determined by western blot and reverse transcription quantitative polymerase chain reaction (RT‐qPCR) analyses, respectively. The expressions of tight ZO‐1, Occludin, and Claudin‐1 were also measured by western blot assay and immunofluorescence staining. The 16S rRNA gene sequence was used to measure the composition of gut microbiota. The co‐administration of FE and SH improved the body weight, number of fecal pellets, fecal moisture, abdominal with drawal reflex score, and gastrointestinal transit rate in IBS‐C rats. The unique efficacy of combination depended on the regulation of balance between excitatory and inhibitory neurotransmitters, enhancement of intestinal barrier function, and activation of SCF/c‐Kit pathway. The gut microbiota structure was also restored. The ability of FE combined with SH to regulate SCF/c‐Kit signaling pathway, enhance intestinal barrier function, and modulate gut microbiota contributes to their efficacy in managing IBS‐C in rats.

show abstract

Section: Resultsmentioning

confidence: 74%

Section: Effects On Serum Neurotransmittermentioning

confidence: 77%

Combination of fenchone and sodium hyaluronate ameliorated constipation‐predominant irritable bowel syndrome and underlying mechanisms

Cui,

Hua,

Zou

et al. 2023

Chem Biol Drug Des

View full text Add to dashboard Cite

show abstract

“…Mechanisms of individual herb actions for PD were summarized in Supplementary File 2 . These frequently used herbs exerted evident antioxidant, neuroprotective, anti-apoptosis, anti-neuroinflammatory effects, except for Citrus aurantium L. [mainly involved anti-constipation effects (Yan et al, 2020 ; Gong et al, 2023 )] and Poria cocos (Schw.) Wolf [possessing antidepressant and sedative-hypnotic effects (Shah et al, 2014 ; Huang et al, 2020 ; Pang et al, 2020 ; Chen et al, 2021 ; Kim et al, 2022 )].…”

Section: Discussionmentioning

confidence: 99%

Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records

Lyu,

Zhang,

Mao

et al. 2024

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

BackgroundParkinson's disease (PD) is a progressive neurodegenerative condition. Chinese medicine therapies have demonstrated effectiveness for PD in controlled settings. However, the utilization of Chinese medicine therapies for PD in real-world clinical practice and the characteristics of patients seeking these therapies have not been thoroughly summarized.MethodThe study retrospectively analyzed initial patient encounters (PEs) with a first-listed diagnosis of PD, based on electronic medical records from Guangdong Provincial Hospital of Chinese Medicine between July 2018 and July 2023.ResultsA total of 3,206 PEs, each corresponding to an individual patient, were eligible for analyses. Approximately 60% of patients made initial visits to the Chinese medicine hospital after receiving a PD diagnosis, around 4.59 years after the onset of motor symptoms. Over 75% of the patients visited the Internal Medicine Outpatient Clinic at their initial visits, while a mere 13.85% visited PD Chronic Care Clinic. Rest tremor (61.98%) and bradykinesia (52.34%) are the most commonly reported motor symptoms, followed by rigidity (40.70%). The most commonly recorded non-motor symptoms included constipation (31.88%) and sleep disturbance (25.27%). Integration of Chinese medicine and conventional medicine therapies was the most common treatment method (39.15%), followed by single use of Chinese herbal medicine (27.14%). The most frequently prescribed herbs for PD included Glycyrrhiza uralensis Fisch. (gan cao), Astragalus mongholicus Bunge (huang qi), Atractylodes macrocephala Koidz. (bai zhu), Angelica sinensis (Oliv.) Diels (dang gui), Rehmannia glutinosa (Gaertn.) DC. (di huang), Paeonia lactiflora Pall. (bai shao), Bupleurum chinense DC. (chai hu), Citrus aurantium L. (zhi qiao/zhi shi/chen pi), Panax ginseng C. A. Mey. (ren shen), and Poria cocos (Schw.) Wolf (fu ling). These herbs contribute to formulation of Bu zhong yi qi tang (BZYQT).ConclusionPatients typically initiated Chinese medical care after the establishment of PD diagnosis, ~4.59 years post-onset of motor symptoms. The prevalent utilization of CHM decoctions and patented Chinese herbal medicine products, underscores its potential in addressing both motor and non-motor symptoms. Despite available evidence, rigorous clinical trials are needed to validate and optimize the integration of CHM, particularly BZYQT, into therapeutic strategies for PD.

show abstract

Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora

Yang,

Huang,

Luo

et al. 2024

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Prokinetic effects of Citrus reticulata and Citrus aurantium extract with/without Bupleurum chinense using multistress-induced delayed gastric emptying models

Cited by 3 publications

References 22 publications

Combination of fenchone and sodium hyaluronate ameliorated constipation‐predominant irritable bowel syndrome and underlying mechanisms

Combination of fenchone and sodium hyaluronate ameliorated constipation‐predominant irritable bowel syndrome and underlying mechanisms

Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records

Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora

Contact Info

Product

Resources

About