Prokinetic Activity ofPrunus persica(L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats

Abstract

The peach tree, Prunus persica (L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional Chinese medicine to treat gut motility disorders. But few studies have explored the pharmacological effect of Prunus persica (L.) Batsch flowers on gastrointestinal motility. In this study, the activities of different extracts from Prunus persica (L.) Batsch flowers on the smooth muscle contractions were evaluated using isolated colon model, and the ethyl acetate extract (EAE) showed the strongest effects in vitro. EAE (10−8–10−5 g/mL) caused a concentration-dependent stimulatory effect in rat colonic tissue. Additionally, ketotifen (100 µM), cimetidine (10 µM), and pyrilamine (1 µM) produced a significant inhibition of contractions caused by EAE. Furthermore, immunofluorescence and toluidine blue staining revealed increased numbers of mast cells in the EAE group, and EAE increased histamine release from the colonic tissues. These data indicate that EAE has significant prokinetic activity and acts by a mechanism that mainly involves mast cell degranulation. Our study provides a pharmacological basis for the use of an extract of Prunus persica (L.) Batsch flowers in the treatment of gut motility disorders.

The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish

“…7 Many studies have conducted research on food ingredients, and their findings can be explored for the treatment of constipation. These food ingredients include honey, 8 konjac glucomannan (KGM), 9 sweet potato, 10 aloe, 11 Prunus persica, 12 oligosaccharides, 13 hemp seed, 14 and castor oil, 15 all of which were shown to be effective at promoting relief from constipation. However, no studies have focused on the potential interactions between probiotics and natural food ingredients for the treatment of constipation.…”

Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice

“…Prunus persica (L.) Batsch (Rosaceae family) is a deciduous fruit tree that originated in China and is now cultivated worldwide for its fruit, peach. The seeds, flowers, and leaves of P. persica have long been used as folk medicine in China and Korea [5,6,7]. In particular, the flower of P. persica (PPF), commonly called the peach blossom, has been used as a purgative, diuretic, and cosmetic [6,7].…”

“…The seeds, flowers, and leaves of P. persica have long been used as folk medicine in China and Korea [5,6,7]. In particular, the flower of P. persica (PPF), commonly called the peach blossom, has been used as a purgative, diuretic, and cosmetic [6,7]. Previous studies have revealed several pharmacological effects of PPF, including protection of the skin from ultraviolet radiation [8,9], inhibition of melanogenesis [10], stimulation of intestinal motility [6], and purgative action [11].…”

“…In particular, the flower of P. persica (PPF), commonly called the peach blossom, has been used as a purgative, diuretic, and cosmetic [6,7]. Previous studies have revealed several pharmacological effects of PPF, including protection of the skin from ultraviolet radiation [8,9], inhibition of melanogenesis [10], stimulation of intestinal motility [6], and purgative action [11]. PPF is currently consumed as a tea for weight loss in China and Korea; however, its anti-obesity effects have yet to be demonstrated in vitro or in vivo.…”

Prevention Effect of Prunus persica Flos Extract from Reactive Oxygen Species Generation and Matrix Metalloproteinases Production Induced by UVB Irradiation in Human Skin Cells

“…사람 피부에는 19종의 MMP가 존재하는데 그 중 MMP-1, MMP-3, MMP-9만 UV에 의하여 증가한다 (Quan et al, 2009 (Quan et al, 2009). 한편, 콜라겐 1형은 섬유아세포에서 procollagen 형 태로 합성되어 세포외기질로 분비되기 때문에 (Hong et al, 2015;Hwang et al, 2014) (Han et al, 2015). 또한, Heo et al (2001) (Li & Wang, 2011;Liang et al, 1999 Figure 4B).…”