Prokaryotic and eukaryotic toxicity of halloysite decorated with photoactive nanoparticles

Stavitskaya, Anna; Khusnetdenova, Elnara; Винокуров, В. А.; Lvov, Yuri; Fakhrullin, Rawil

doi:10.1039/d2cc02439j

Cited by 11 publications

(12 citation statements)

References 87 publications

(120 reference statements)

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“…TEM images ( Figure 5 d,g) provided additional insight as high-contrast gold nanorods (indicated by the red arrows) were observable at the interface between the damaged bacterial cells and HNTs. Similar evidence of such morphological cell damage has been reported for bacterial cells inactivated using plasmonic nano-antimicrobials [ 7 , 19 ].…”

Section: Resultssupporting

confidence: 79%

“…This proof-of-concept work paves the way for the potential application of the described hybrids for the effective and triggered photothermal neutralization of target bacteria, while the temperature can be kept at physiological conditions. Moreover, these hybrids can potentially serve as ‘mothership’ carriers for any combination of antimicrobial nanoparticles [ 19 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, colloidal AuNPs tend to aggregate over time, which can in turn alter their intrinsic surface plasmon absorption [ 18 ]. To mitigate these shortcomings, it has been proposed to immobilize AuNPs onto a larger particulate system—natural clay halloysite nanotubes (HNTs) [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, HNTs have emerged as a prominent nanomaterial for various biomedical applications, including tableting [ 25 ], drug delivery [ 22 , 26 , 27 , 28 , 29 ], tissue engineering [ 27 ], bioimaging [ 30 , 31 ], anti-cancer therapy [ 32 , 33 ], and antimicrobial solutions [ 34 ]. The latter three have been often realized by utilizing HNTs as ‘mothership’ carriers for cargoes ranging from quantum dots [ 35 , 36 ] through metal oxides NPs to precious metals [ 19 , 34 ], including gold [ 37 , 38 , 39 , 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

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Gold Nanorod-Incorporated Halloysite Nanotubes Functionalized with Antibody for Superior Antibacterial Photothermal Treatment

et al. 2022

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The global spread of antibiotic-resistant strains, and the need to protect the microflora from non-specific antibiotics require more effective and selective alternatives. In this work, we demonstrate for the first time a superior antibacterial photothermal effect of plasmonic gold nanorods (AuNRs) via their incorporation onto natural clay halloysite nanotubes (HNTs), which were functionalized with anti-E. coli antibodies (Ab-HNTs). AuNRs were incorporated onto the Ab-HNTs through a facile freeze–thaw cycle, and antibody integrity following the incorporation was confirmed via infrared spectroscopy and fluorescence immunolabeling. The incorporation efficiency was studied using UV-Vis absorption and transmission electron microscopy (TEM). Mixtures of E. coli and AuNR-Ab-HNTs hybrids or free AuNRs were irradiated with an 808 nm laser at 3–4 W cm−2, and the resulting photothermal antibacterial activity was measured via plate count. The irradiated AuNR-Ab-HNTs hybrids exerted an 8-fold higher antibacterial effect compared to free AuNR under 3.5 W cm−2; whereas the latter induced a 6 °C-higher temperature elevation. No significant antibacterial activity was observed for the AuNR-Ab-HNTs hybrid against non-target bacteria species (Serratia marcescens and Staphylococcus epidermidis). These findings are ascribed to the localization of the photothermal ablation due to the binding of the antibody-functionalized clay to its target bacteria, as supported through TEM imaging. In the future, the HNTs-based selective carriers presented herein could be tailored with other antibacterial nanoparticles or against another microorganism via the facile adjustment of the immobilized antibody.

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Section: Resultssupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gold Nanorod-Incorporated Halloysite Nanotubes Functionalized with Antibody for Superior Antibacterial Photothermal Treatment

et al. 2022

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“…11 It should be noted that the establishment of a covalent bond between HNTs and a polymeric matrix is helpful for lowering the phase separation behavior, compared with analogs prepared via physical blending technology. 12 Lvov and co-workers demonstrated surface-initiated atom transfer radical polymerization (ATRP) by anchoring dopamine derivative units (Dopa) onto the HNT surface. 13 The Dopa-modified HNTs can be viewed as nanosized ATRP initiators.…”

mentioning

confidence: 99%

Exploring maleimide-anchored halloysites as nanophotoinitiators for surface-initiated photografting strategies

Zhao

Huang

et al. 2022

Chem. Commun.

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Modified Halloysite as Catalyst for the Conversion of Hydroxymethylfurfural to Furandicarboxylic Acid: A DFT Investigation

Bertini,

Ferrante,

Guercio

et al. 2024

ChemCatChem

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The reaction steps involved in the 5‐hydroxymethylfurfural to 2,5‐furandicarboxylic acid conversion by means of H2O2 were investigated employing a dedicated computational protocol based on density functional theory. The catalytic environment of choice was a molecular model representing a portion of the halloysite nanotube outer surface, functionalized by an organosilane, the 3‐aminopropyltriethoxysilane, whose amino group bonds one gold atom. At this stage of the investigation, the process was wholly detailed in terms of the interactions between the reaction intermediates and the catalyst, and the reaction standard free energies. In addition, the energy barriers of the elementary steps involving the hydrogen migration from the adsorbed organic species to the gold atom were analyzed. On the basis of the interaction geometries, a certain distinction among the preferred reaction path can be inferred as a function of the net negative charge characterizing the catalyst outer surface. Since the inner surface of halloysite can represent the acid environment needed to obtain 5‐hydroxymethylfurfural through dehydration of fructose, the present study is framed in a wider research field where the possibility to consider functionalized halloysite as one‐pot reactor for the valorization of biomass is explored.

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Prokaryotic and eukaryotic toxicity of halloysite decorated with photoactive nanoparticles

Abstract: In this paper we critically analyse the toxicity of halloysite decorated with photoactive nanoparticles on prokaryotic and eukaryotic cells and fabrication of photoactive halloysite-based materials to tackle the microbial resistance to antibiotics.

Cited by 11 publications

References 87 publications

Gold Nanorod-Incorporated Halloysite Nanotubes Functionalized with Antibody for Superior Antibacterial Photothermal Treatment

Gold Nanorod-Incorporated Halloysite Nanotubes Functionalized with Antibody for Superior Antibacterial Photothermal Treatment

Exploring maleimide-anchored halloysites as nanophotoinitiators for surface-initiated photografting strategies

Modified Halloysite as Catalyst for the Conversion of Hydroxymethylfurfural to Furandicarboxylic Acid: A DFT Investigation

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