Prokaryotic and eukaryotic dual-expression plasmid-mediated delivery of Campylobacter jejuni antigens by live-attenuated Salmonella: A strategy for concurrent Th1 and Th2 immune activation and protection in chickens

Chandran, Sivasankar; Hewawaduge, Chamith; Aganja, Ram Prasad; Lee, John Hwa

doi:10.1016/j.dci.2024.105134

Cited by 1 publication

(1 citation statement)

References 52 publications

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“…To reduce the prevalence of common poultry pathogens, vaccination programs are constantly being developed for commercial poultry flocks [100][101][102][103][104][105]. Some of these pathogens may be associated with elevated flock morbidity (Clostridium perfringens) while others are more closely associated with human foodborne illnesses (Campylobacter jejuni).…”

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 99%

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Beck,

Zhao,

Erf

2024

Applied Sciences

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At the turn of the 21st century, the importance of maintaining a balanced microbiome was brought to the forefront of the microbiology, immunology, and physiology research fields. Exploring the complex interactions between vaccine administration, mucosal microbiome, oral tolerance, and enteric inflammation in health and disease is challenging since environmental factors (such as diet and sanitation) have major influences on gut microbiota composition. High enteric pathogen load has been shown to contribute to dampened cell-mediated and humoral immune responses to vaccines in human case studies, either through elevated enteric inflammation or increased tolerance to environmental microbes. Although antibiotic and probiotic interventions have been evaluated in human health as well as research animal models, effective measures to mediate vaccine hyporesponsiveness are still ill-defined. Research in this field is becoming increasingly important for managing flock health in commercial poultry production, especially as antibiotic-free production is more prevalent and vaccination programs remain extensive during the first weeks of a bird’s life. By understanding the cellular interactions between commensal microbiota, vaccine antigens, and the host immune system (particularly in avian models), advancements in bacterial and viral vaccine immunogenicity could lead to improved flock health in meat-type and egg-type chickens in the future.

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Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 99%

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Beck,

Zhao,

Erf

2024

Applied Sciences

View full text Add to dashboard Cite

show abstract

Prokaryotic and eukaryotic dual-expression plasmid-mediated delivery of Campylobacter jejuni antigens by live-attenuated Salmonella: A strategy for concurrent Th1 and Th2 immune activation and protection in chickens

Cited by 1 publication

References 52 publications

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

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