Projections of the zona incerta in the cat, with stimulation controls

Kaelber, William W.; Smith, Tom

doi:10.1016/0014-4886(79)90192-4

Cited by 77 publications

(18 citation statements)

References 29 publications

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“…Consistent with this, combined electrophysiological and anatomical data have shown that the ventral and dorsal ZI contain units responding to innocuous inputs, but the ZIV displays larger receptive fields and contains units that also respond to noxious stimulation of cutaneous and deep receptors (Nicolelis et al, 1992). In cats, escape responses can be elicited following stimulation of the ZI (Kaelber and Smith, 1979;Kaelber, 1981). ZIV neurons project to the middle and deep layers of the superior colliculus (Ricardo, 1981;Nicolelis et al, 1992, Romanowski et al, 1985, an area that contains numerous nociceptive-specific neurons with ''whole body'' receptive fields reminiscent to the electrophysiological features of SRD cells (Redgrave et al, 1996a).…”

Section: Projections From the Srd To The Diencephalon: Functional Conmentioning

confidence: 66%

Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: A retrograde and anterograde tracer study in the rat

et al. 1998

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The distribution and organization of diencephalic projections from the subnucleus reticularis dorsalis (SRD) and the neighbouring cuneate nucleus (Cu) were studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin in SRD and Cu and wheat germ agglutinin-apo horseradish peroxidase-gold in some selected thalamic areas. As previously reported, the efferent projections from the Cu were essentially contralateral and terminated mainly in the ventroposterolateral thalamic nucleus. Less dense terminals from the Cu were also observed in the posterior thalamic group, the ventral aspect of the zona incerta and the caudal and dorsal portion of the reuniens area. Retrograde tracer injections in the medial ventroposterolateral thalamic nucleus labeled numerous cells in the contralateral Cu, with a smaller number in the gracile nucleus. From the SRD, terminals were observed in the lateral aspect of the ventromedial thalamic nucleus, the lateral parafascicular area and, to a lesser extent, in the ventral aspect of the zona incerta and the core of the reuniens area. Retrograde tracer injections in the lateral part of the ventromedial thalamic nucleus labeled cells in the caudal medulla, many of which were located in the dorsal-most aspect of the SRD throughout its caudo-rostral extent. The existence of SRD-thalamic connections reinforces the idea that the caudal reticular formation is an important nociceptive relay to the thalamus. Our data shed new light on old hypotheses suggesting that, in addition to spino-thalamic pathways, spino-reticulo-thalamic pathways may play an important role in distributing pain signals to the forebrain.

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Section: Projections From the Srd To The Diencephalon: Functional Conmentioning

confidence: 66%

Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: A retrograde and anterograde tracer study in the rat

et al. 1998

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“…Other functions of the Zl have also been reported in the literature. These include control of food and water intake [5,9,32], nocicep tion [18] and visual discrimination [22]. This variety of func tion is supported by the extensive efferent connections of the ZI as reported by Ricardo [30].…”

Section: Discussionmentioning

confidence: 79%

Evidence that the Dopaminergic Incerto-Hypothalamic Tract Has a Stimulatory Effect on Ovulation and Gonadotrophin Release

Daly

et al. 1984

Neuroendocrinology

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2 µg dopamine (DA) were injected into particular hypothalamic sites containing dopaminergic nerve terminals, on the morning of pro-oestrus in cyclic rats, in which ovulation was blocked by administration of 35 mg/kg pento-barbitone Na, in the afternoon of pro-oestrus. DA in a specific area of the zona incerta (ZI) (medial area at A 5.4 mm; de Groot atlas), and medial anterior hypothalamus (AH) overcame the pentobarbitone block and induced ovulation. Injections into the median eminence and preoptic area were ineffective, as were injections of 5-hydroxytryptamine and noradrenaline into the ZI. Injection of 2 µg haloperidol and lesions in the ZI inhibited ovulation in otherwise untreated cyclic rats. Lesions induced constant dioestrus for 14 ± 0.7 days, but the animals were not pseudopregnant. 2 µg DA were also injected into the ZI of ovariectomised rats primed with 2 µg oestradiol benzoate 48 h before; this treatment stimulated a rise in plasma LH approximately 40 min later. These findings indicate that the dopaminergic incerto-hypothalamic tract which has nerve terminals in the ZI and AH has a stimulatory role in the control of gonadotrophin release.

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“…When these anatomical reports are considered, it is of interest that most of the FR neurons were excited by nociceptive and/or non-nociceptive stimulation. The lesions of the FH blocked nociceptive escape responses (Kaelber 1977), and the stimulation induced ocular and head rotation (Hyde and Toczek 1962;Kaelber and Smith 1979). This would suggest that the FH contributes to the motor reactions to nociception as a part of non-pyramidal circuitry (Bowsher 1975).…”

Section: Discussionmentioning

confidence: 95%

“…The FH receives direct ascending input from the medial magnocellular region of the medullary and pontine reticular formation (Nauta and Kuypers 1958) and from the midbrain reticular formation (Bowsher 1975) belonging to the paleospinothalamic nociceptive system (Bowsher 1957;Kaelber and Smith 1979;Kerr 1979). On the other hand, this area receives input directly from the dorsal column nuclei of the medulla (Boivie 1971) which is known as belonging to the lemniscal non-nociceptive system (Mountcastle and Darian-Smith 1968).…”

Section: Discussionmentioning

confidence: 99%

Nociceptive and non-nociceptive responses of neurons in the medial subthalamic region and lateral hypothalamic area of cats and their relationship to the effects of morphine and pentazocine.

Miyakawa

Okuda

Shima

et al. 1982

Tohoku J. Exp. Med.

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Projections of the zona incerta in the cat, with stimulation controls

Cited by 77 publications

References 29 publications

Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: A retrograde and anterograde tracer study in the rat

Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: A retrograde and anterograde tracer study in the rat

Evidence that the Dopaminergic Incerto-Hypothalamic Tract Has a Stimulatory Effect on Ovulation and Gonadotrophin Release

Nociceptive and non-nociceptive responses of neurons in the medial subthalamic region and lateral hypothalamic area of cats and their relationship to the effects of morphine and pentazocine.

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