Projections of the reticular complex of the thalamus onto physiologically characterized regions of the medial geniculate body

Rouiller, Eric M.; Colomb, Etienne; Capt, Mauricette; Ribaupierre, F. de

doi:10.1016/0304-3940(85)90190-9

Cited by 59 publications

(14 citation statements)

References 15 publications

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“…In this regard, the rodent MGB differs from the MGB of other species, such as the cat, but also from the neighboring lateral geniculate nucleus, both of which have GABAergic interneurons (Arcelli et al, 1996; Winer and Larue, 1996). Synaptic inhibition in the MGB arrives via feedforward GABA projections from the IC (Winer et al, 1996; Peruzzi et al, 1997; Ito et al, 2011; Rudiger et al, 2013; Mellott et al, 2014) or from the reticular nucleus of the thalamus (Rouiller et al, 1985; Bartlett and Smith, 1999; Zhang et al, 2008), which makes precise topographic connections with sensory thalamic nuclei (Lam and Sherman, 2007; Cotillon-Williams et al, 2008). …”

Section: Discussionmentioning

confidence: 99%

Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation

Chambers

Salazar

Polley

2016

Front. Neural Circuits

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Neurons at higher stages of sensory processing can partially compensate for a sudden drop in peripheral input through a homeostatic plasticity process that increases the gain on weak afferent inputs. Even after a profound unilateral auditory neuropathy where >95% of afferent synapses between auditory nerve fibers and inner hair cells have been eliminated with ouabain, central gain can restore cortical processing and perceptual detection of basic sounds delivered to the denervated ear. In this model of profound auditory neuropathy, auditory cortex (ACtx) processing and perception recover despite the absence of an auditory brainstem response (ABR) or brainstem acoustic reflexes, and only a partial recovery of sound processing at the level of the inferior colliculus (IC), an auditory midbrain nucleus. In this study, we induced a profound cochlear neuropathy with ouabain and asked whether central gain enabled a compensatory plasticity in the auditory thalamus comparable to the full recovery of function previously observed in the ACtx, the partial recovery observed in the IC, or something different entirely. Unilateral ouabain treatment in adult mice effectively eliminated the ABR, yet robust sound-evoked activity persisted in a minority of units recorded from the contralateral medial geniculate body (MGB) of awake mice. Sound driven MGB units could decode moderate and high-intensity sounds with accuracies comparable to sham-treated control mice, but low-intensity classification was near chance. Pure tone receptive fields and synchronization to broadband pulse trains also persisted, albeit with significantly reduced quality and precision, respectively. MGB decoding of temporally modulated pulse trains and speech tokens were both greatly impaired in ouabain-treated mice. Taken together, the absence of an ABR belied a persistent auditory processing at the level of the MGB that was likely enabled through increased central gain. Compensatory plasticity at the level of the auditory thalamus was less robust overall than previous observations in cortex or midbrain. Hierarchical differences in compensatory plasticity following sensorineural hearing loss may reflect differences in GABA circuit organization within the MGB, as compared to the ACtx or IC.

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Section: Discussionmentioning

confidence: 99%

Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation

Chambers

Salazar

Polley

2016

Front. Neural Circuits

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“…MGB neurons are excited by glutamatergic fiber tracts from both the ascending (Bartlett and Smith, 1999) and descending (Rouiller and Welker, 1991;Winer and Larue, 1987) pathways. In rats, only 1% of MGB neurons are GABAergic interneurons (Arcelli et al, 1997;, and the major inhibitory sources in the MGB are from the IC (Peruzzi et al, 1997; and from the thalamic reticular nucleus (TRN) (Rouiller et al, 1985;Zhang et al, 2008) (Fig. 1a).…”

Section: Introductionmentioning

confidence: 99%

Activation of presynaptic GABAB receptors modulates GABAergic and glutamatergic inputs to the medial geniculate body

Luo

et al. 2011

Hearing Research

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“…The present results concern connections of the TRN in addition to the primary sensory connections. In fact, the area of the TRN where we detected neuronal spikes following sound stimulation was more rostral than the previously described auditory sectors located in the caudoventral part of the TRN (17). The rostral part of the TRN has connections to the LP and LM-SG, where we found auditory neurons.…”

Section: Discussionmentioning

confidence: 81%

“…For the visual system, the caudodorsal part of the TRN contains inhibitory neurons that project back to the LGN; these cells receive input from collaterals of both thalamocortical and corticothalamic fibers (9). The caudoventral and centroventral parts of the TRN could play a similar role in relation to the MGB and VB, respectively (1,17). Sensory maps have been described in the somatosensory sector of the TRN (19) and a retinotopic organization of the visual sector of the TRN was reported in the rabbit (8).…”

Section: Discussionmentioning

confidence: 98%

“…Highly topographic projections have been shown in the connections between the visual sector and the dorsal lateral geniculate nucleus (LGN) (8), between the auditory sector and the medial geniculate body (MGB) (16,17) and between the somatosensory sector and the ventrobasal complex (VB) (18). For the visual system, the caudodorsal part of the TRN contains inhibitory neurons that project back to the LGN; these cells receive input from collaterals of both thalamocortical and corticothalamic fibers (9).…”

Section: Discussionmentioning

confidence: 99%

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