Projections of the medial cerebellar nucleus to oculomotor‐related midbrain areas in the rat: An anterograde and retrograde HRP study

Gonzalo-Ruiz, A.; Leichnetz, George R.; Hardy, Sandro

doi:10.1002/cne.902960308

Cited by 41 publications

(24 citation statements)

References 36 publications

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“…In respect to cerebellar-PAG projections, Whiteside and Snider (1953) showed that electrical stimulation of vermal lobule VII in the anesthetized cat can evoke responses in the dorsal PAG with two distinct latencies (2–3 ms and 8–12 ms), which raises the possibility that multiple cerebello-PAG pathways exist. Consistent with a direct (short latency) projection, anatomical tracing studies have shown the existence of efferent fastigial projections to the PAG in a number of species (Martin et al (1974) in the opossum; Beitz (1982); Gonzalo-Ruiz and Leichnetz (1987), Gonzalo-Ruiz et al (1990) and Teune et al (2000) in the rat, and Gonzalo-Ruiz et al (1988) in monkey). Many of these studies have advanced the view that the projections subserve an oculomotor function.…”

Section: Cerebellar Output To Survival Circuitsmentioning

confidence: 80%

The olivo-cerebellar system and its relationship to survival circuits

Watson¹,

Koutsikou²,

Cerminara³

et al. 2013

Front. Neural Circuits

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How does the cerebellum, the brain’s largest sensorimotor structure, contribute to complex behaviors essential to survival? While we know much about the role of limbic and closely associated brainstem structures in relation to a variety of emotional, sensory, or motivational stimuli, we know very little about how these circuits interact with the cerebellum to generate appropriate patterns of behavioral response. Here we focus on evidence suggesting that the olivo-cerebellar system may link to survival networks via interactions with the midbrain periaqueductal gray, a structure with a well known role in expression of survival responses. As a result of this interaction we argue that, in addition to important roles in motor control, the inferior olive, and related olivo-cortico-nuclear circuits, should be considered part of a larger network of brain structures involved in coordinating survival behavior through the selective relaying of “teaching signals” arising from higher centers associated with emotional behaviors.

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Section: Cerebellar Output To Survival Circuitsmentioning

confidence: 80%

The olivo-cerebellar system and its relationship to survival circuits

Watson¹,

Koutsikou²,

Cerminara³

et al. 2013

Front. Neural Circuits

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“…; Saint‐Cyr, ; Stuesse & Newman, ; Onodera & Hicks, ) and deep cerebellar nuclei (Gonzalo‐Ruiz et al . ; Ruigrok & Voogd, ; Ruigrok & Teune, ), and thus the sensory signals are assumed to be subject to multiple modulation by higher brain regions. These lines of evidence suggest the importance of this network in cerebellar functions.…”

Section: Discussionmentioning

confidence: 99%

The anatomical pathway from the mesodiencephalic junction to the inferior olive relays perioral sensory signals to the cerebellum in the mouse

Kubo

Aiba

Hashimoto

2018

The Journal of Physiology

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Key points Perioral tactile signals are transmitted via the infraorbital nerve (ION) to trigeminal nuclei. Each cerebellar Purkinje cell (PC) receives this signal as complex spikes (CSs) via a climbing fibre (CF) emerging from the inferior olive (IO).The anatomical pathway from trigeminal nuclei to the IO is not clearly identified.In the present study, we examined candidate anatomical pathways for perioral sensory signalling by analysing CSs recorded from PCs in male mice by single unit recording.CS generation by ION stimulation was inhibited by injection of a GABAA receptor agonist, muscimol, into the contralateral mesodiencephalic junction, which is referred to as the area parafascicularis prerubralis (PfPr). The number of CSs evoked by mechanical whisker stimulation was also decreased by contralateral PfPr inhibition.These results suggest the existence of a sensory signalling pathway to the IO via the PfPr in mice. AbstractPerioral tactile signals are transmitted via the infraorbital nerve (ION) to trigeminal nuclei. Each cerebellar Purkinje cell receives this signal as complex spikes (CSs) via a climbing fibre emerging from the inferior olive (IO). However, the anatomical pathway from the trigeminal nuclei to the IO is not clearly identified. In the present study, we recorded CSs from Purkinje cells in male mice by single unit recording, and examined the signal transduction pathway. CSs were evoked by electrical stimulation of the ipsilateral or contralateral ION with a latency of 20–70 ms. CS generation by ipsilateral ION stimulation was inhibited by injection of a GABAA receptor agonist, muscimol, into the contralateral mesodiencephalic junction, ranging from around the fasciculus retroflexus to the interstitial nucleus of Cajal, which is referred to as the area parafascicularis prerubralis (PfPr). CSs evoked by contralateral ION stimulation were also suppressed by muscimol injection into the PfPr, although the effective area was more restricted. Furthermore, CSs evoked by mechanical stimulation around the whisker region were suppressed by PfPr inhibition. We also found that the primary motor cortex plays a role to suppress this signalling pathway. These results indicate the existence of an anatomical pathway for conducting perioral sensory signals to the IO via the PfPr.

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“…There are reciprocal connections with the supraoculomotor gray, an area implicated in cerebellar modulation of near-object visual responses (Gonzalo-Ruiz et al, 1990;May et al, 1992). The nucleus of Darkschewitsch, which projects to midline and intralaminar thalamic nuclei (Krout et al, 2002a) and the IGL (Horowitz et al, 2004), is part of the premotor circuitry controlling eyelid responses (Morcuende et al, 2002).…”

Section: Visuomotor System Connectionsmentioning

confidence: 99%

Medial vestibular connections with the hypocretin (orexin) system

2005

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The mammalian medial vestibular nucleus (MVe) receives input from all vestibular endorgans and provides extensive projections to the central nervous system. Recent studies have demonstrated projections from the MVe to the circadian rhythm system. In addition, there are known projections from the MVe to regions considered to be involved in sleep and arousal. In this study, afferent and efferent subcortical connectivity of the medial vestibular nucleus of the golden hamster (Mesocricetus auratus) was evaluated using cholera toxin subunit-B (retrograde), Phaseolus vulgaris leucoagglutinin (anterograde), and pseudorabies virus (transneuronal retrograde) tract-tracing techniques. The results demonstrate MVe connections with regions mediating visuomotor and postural control, as previously observed in other mammals. The data also identify extensive projections from the MVe to regions mediating arousal and sleep-related functions, most of which receive immunohistochemically identified projections from the lateral hypothalamic hypocretin (orexin) neurons. These include the locus coeruleus, dorsal and pedunculopontine tegmental nuclei, dorsal raphe, and lateral preoptic area. The MVe itself receives a projection from hypocretin cells. CTB tracing demonstrated reciprocal connections between the MVe and most brain areas receiving MVe efferents. Virus tracing confirmed and extended the MVe afferent connections identified with CTB and additionally demonstrated transneuronal connectivity with the suprachiasmatic nucleus and the medial habenular nucleus. These anatomical data indicate that the vestibular system has access to a broad array of neural functions not typically associated with visuomotor, balance, or equilibrium, and that the MVe is likely to receive information from many of the same regions to which it projects.

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Projections of the medial cerebellar nucleus to oculomotor‐related midbrain areas in the rat: An anterograde and retrograde HRP study

Cited by 41 publications

References 36 publications

The olivo-cerebellar system and its relationship to survival circuits

The olivo-cerebellar system and its relationship to survival circuits

The anatomical pathway from the mesodiencephalic junction to the inferior olive relays perioral sensory signals to the cerebellum in the mouse

Medial vestibular connections with the hypocretin (orexin) system

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