Projections of caudal fasciculus gracilis to nucleus gracilis and other medullary structures, and Clarke's nucleus in the rat

Ganchrow, Donald; Bernstein, Jerald J.

doi:10.1016/0006-8993(81)90347-4

Cited by 24 publications

(3 citation statements)

References 23 publications

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“…Of 44 lesioned rats, 39 had 90-100% destruction of the dorsal column and partial-to-complete damage of the corticospinal tract (CS). CS of the rat occupies the ventral portion of the dorsal funiculus, lying ventrally subjacent to the dorsal column [Ganchrow and Bernstein, 1981a;King, 19101. Examples of lesion and control material including a fuller description of lesion size estimation appear elsewhere [Ganchrow et al, 19801. dental wax.…”

Section: Methodsmentioning

confidence: 99%

Bouton renewal patterns in rat hindlimb cortex after thoracic dorsal funicular lesions

Ganchrow

Bernstein²

1981

J of Neuroscience Research

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The transneuronal effect of bilateral, dorsal funicular lesions (T 12) on the frequency of boutons on cells in layer IV of hindlimb cortex was studied. Adult rats were utilized 1, 2, 3, 7, 14, 30, 45, 60, 90, or 120 days postoperative (DPO), and tissue was processed for the light microscopic visualization of silver-impregnated boutons (Rasmussen method). Bouton counts were taken on soma, or along 5- and 10-micrometers segments or proximal dendrite branching from soma. The soma diameter also was measured on those neurons chosen for bouton counts on the circumference of the soma. Statistically significant, increased afferentation on soma and proximal dendrite occurred during the first postlesion week relative to longer survival times; bouton counts on the proximal dendrite showed a trend (not statistically significant) toward increases above normal. These data mirror similar, consistent increases in bouton counts reported in thalamic ventroposterolateral nucleus of these same cases. At 14 DPO, bouton counts on the soma decreased below normal (P less than 0.005) and, except at 60 DPO, remained so through 120 DPO (P less than 0.025). Bouton counts on the proximal dendrite also decreased below normal at 14 DPO (P less than 0.005), thereafter exhibiting either periodic (along 5-micrometers) or extended (along 10-micrometers) periods in significant decreases from normal. Correlations in lesioned cases between the number of boutons on the soma and either bouton counts on proximal dendrite or soma diameter were positive and statistically significant (P less than 0.005 in all correlations). Possible anterograde (via the dorsal column-medial lemniscal system) and/or retrograde (via the corticospinal tract) transneuronal mediation of these effects in hindlimb cortex is discussed.

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Section: Methodsmentioning

confidence: 99%

Bouton renewal patterns in rat hindlimb cortex after thoracic dorsal funicular lesions

Ganchrow

Bernstein²

1981

J of Neuroscience Research

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“…The destination of their axons in the central nervous system depends on the nature of the sensation they transmit. The nociceptive fibers terminate in lamina 1–2 of the dorsal horn of the spinal cord (Light and Perl, ; Jancso and Kiraly, ), the proprioceptive axons terminate in lamina 3–5 (Molander and Grant, ; Rivero‐Melian, ) or the dorsal nucleus of Clarke (Brushart and Mesulam, ; Molander and Grant, ; Rivero‐Melian, ), and the tactile fibers end at cuneate and gracile nuclei in the medulla oblongata (Ganchrow and Bernstein, ; Rivero‐Melian and Grant, ). In addition, DRG neurons and their peripheral fibers possess neuronal subtype‐specific identities (Lawson and Waddell, ; Sann et al, ; Ishii et al, ; Lallemend and Ernfors, ).…”

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Possible Role of the Myelinated Neural Network in the Parietal Peritoneum in Rats as a Mechanoreceptor

Tanaka

Kuwahara-Otani

Maeda

et al. 2017

The Anatomical Record

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A network of myelinated nerve fibers in the peritoneum covers the abdominal wall. We studied the topographic distribution of this network, explored the fibers' destination in the central nervous system, and examined the markers in these fibers in order to identify the nature of the sensation conveyed by the network of nerve fibers in rats. We used Sihler's method, which stains myelinated fibers in whole mount materials, and observed a dense nerve network and endings toward the peritoneal cavity in the peritoneum that covers the abdomen's lateral bulge. We studied the axonal transport of cholera toxin subunit B to investigate the central projections of this network in order to identify its function. After applying the tracer in the peritoneum, we observed many labeled terminals in the medial part of laminae 3-5 of the spinal cord. A small number of labeled terminals was observed in the dorsal nucleus of Clarke and gracile nucleus. Labeled somata were observed in the dorsal root ganglia (DRG). Most (96%) were larger than 35 μm. We performed immunohistochemistry of the abdominal wall, using antiserum against the 200-kD neurofilament (a marker for mechanosensory neurons). We observed many positive nerve fibers in the peritoneum. Because cell bodies in the DRG were large, their nerve terminals ended in the base of the dorsal horn, which is known to transmit proprioceptive information, and the network possesses the marker for mechanosensitive fibers; therefore, it appears that the myelinated nerve network conveys information about distension and/or contraction of the abdominal wall. Anat Rec, 300:1662-1669, 2017. © 2017 Wiley Periodicals, Inc.

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“…( 3 ) What are the clinical consequences of peripheral as compared with central conduction abnormalities? and 17 rats weighing over 300 g (10)(11)(12) weeks old at day 0) were used for acrylamide studies. Injection of acrylarnide (20-30 mg/kg/day i.m.…”

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Slow recovery of central axons in acrylamide neuropathy

et al. 1989

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To study the differential vulnerability of central versus peripheral axons, we observed serial changes in conduction over comparable segments of central and peripheral axons of the primary sensory neuron in 17 rats with acrylamide neuropathy using somatosensory evoked potentials. Central conduction abnormalities persisted even after peripheral conduction and clinical abnormalities had recovered. Morphometric studies showed prompt restoration of the largest-diameter fibers in the peripheral nerve after clinical recovery but persistent or even more severe loss of large- and medium-sized fibers in the cervical gracile tract. This finding suggests that recovery from central-peripheral distal axonopathy begins in the largest peripheral axons, perhaps even at the expense of central axons, and that clinical recovery can occur at a time when central conduction remains abnormal. The selective central axonopathy found in certain chronic degenerative disorders may be a consequence of this slow central recovery process associated with chronic or intermittent metabolic derangements.

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Projections of caudal fasciculus gracilis to nucleus gracilis and other medullary structures, and Clarke's nucleus in the rat

Cited by 24 publications

References 23 publications

Bouton renewal patterns in rat hindlimb cortex after thoracic dorsal funicular lesions

Bouton renewal patterns in rat hindlimb cortex after thoracic dorsal funicular lesions

Possible Role of the Myelinated Neural Network in the Parietal Peritoneum in Rats as a Mechanoreceptor

Slow recovery of central axons in acrylamide neuropathy

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