Projections of anterior hypothalamic neurones to the dorsal and ventral periaqueductal grey in the rat

Semenenko, F. M.; Lumb, Bridget M.

doi:10.1016/0006-8993(92)90139-z

Cited by 46 publications

(24 citation statements)

References 24 publications

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“…We postulated that POA-induced facilitation of BVB is mediated by the ventrolateral PAG because activation of neurones in the ventrolateral PAG produces a pattern of cardiovascular responses similar to that observed upon activation of neurones in the POA (Inui et al 1994), and, in addition, projections from the POA to the ventrolateral PAG have been delineated anatomically (Swanson, 1976;Semenenko & Lumb, 1992 :LI S vagal bradycardia produced by stimulation of the POA were also reduced after the introduction of the lesion (Table 2). After the destruction, both resting blood pressure and heart rate were slightly decreased (from 99-2 to 85 0 mmHg and from 304 to 295 beats min-1, respectively), but the changes were not statistically significant.…”

Section: Effectsmentioning

confidence: 99%

Facilitation of the arterial baroreflex by the preoptic area in anaesthetized rats.

Inui

Nomura

Murase

et al. 1995

The Journal of Physiology

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1. Activation of cell bodies in the ventrolateral part of the midbrain periaqueductal grey matter (PAG) facilitates the arterial baroreflex via the nucleus raphe magnus. The facilitatory effects of stimulation within the hypothalamus on the arterial baroreflex and their relation to the PAG and nucleus raphe magnus were studied in urethane-and chloralose-anaesthetized rats. 2. Systematic mapping experiments revealed that the preoptic area (POA) is the principal location in the hypothalamus of neuronal cell bodies that are responsible for the potentiation of the baroreflex. In addition to provoking hypotension and vagal bradycardia, both electrical and chemical stimulation of the POA produced facilitation of baroreflex vagal bradycardia (BVB) that was evoked by electrical stimulation of the aortic depressor nerve. Baroreflex hypotension was slightly augmented during activation of the POA in vagotomized rats. 3. Selective destruction of cell bodies either in the ventrolateral PAG or in the nucleus raphe magnus reduced facilitation of BVB by the POA. Hypotension and bradycardia due to POA stimulation were also markedly attenuated after such selective destruction. 4. In conclusion, the POA, the ventrolateral PAG and the nucleus raphe magnus constitute a functional complex that produces cardiovascular trophotropic effects including hypotension, vagal bradycardia and baroreflex facilitation.

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Section: Effectsmentioning

confidence: 99%

Facilitation of the arterial baroreflex by the preoptic area in anaesthetized rats.

Inui

Nomura

Murase

et al. 1995

The Journal of Physiology

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“…Retrograde tracing studies showed that the DLPAG projects onto the nucleus reuniens of the thalamus (Risold et al, 1997). DLPAG stimulation with nitric oxide (NO) donors leads to activation of anterior cingulate pathway suggesting a role within an ascending pathway with the nucleus reuniens as a relay station (Risold et al, 1997;Semenenko and Lumb, 1992). The DLPAG also receives projections from the dorsal raphe nucleus at the level of oculomotor nucleus (Vertes, 1991).…”

Section: Introductionmentioning

confidence: 99%

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Madasu

Okine

Olango

et al. 2016

Pharmacological Research

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“…Nevertheless, escape behavior caused by dlPAG stimulation with nitric oxide donors leads to activation of the anterior cingulate (33), suggesting the existence of an ascending path functionally linking the two regions. The nucleus reuniens of the thalamus could be a relay station (41).…”

Section: Cortexmentioning

confidence: 99%

“…Cameron et al (32) compared the projections of neurons located in rostral and caudal portions of the dlPAG and vlPAG and observed that the rostral dlPAG densely projects (33). Another dense projection goes to the VMH, which projects massively to the rostral dlPAG (29).…”

Section: Hypothalamusmentioning

confidence: 99%

Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear

Vianna

Brandão

2003

Braz J Med Biol Res

157

106

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The periaqueductal gray (PAG) has been traditionally considered to be an exit relay for defensive responses. Functional mapping of its subdivisions has advanced our knowledge of this structure, but synthesis remains difficult mainly because results from lesion and stimulation studies have not correlated perfectly. After using a strategy that combined both techniques and a reevaluation of the available literature on PAG function and connections, we propose here that freezing could be mediated by different PAG subdivisions depending on the presence of immediate danger or exposure to related signaling cues. These subdivisions are separate functional entities with distinct descending and ascending connections that are likely to play a role in different defensive responses. The existence of ascending connections also suggests that the PAG is not simply a final common path for defensive responses. For example, the possibility that indirect ascending connections to the cingulate cortex could play a role in the expression of freezing evoked by activation of the neural substrate of fear in the dorsal PAG has been considered.

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Projections of anterior hypothalamic neurones to the dorsal and ventral periaqueductal grey in the rat

Cited by 46 publications

References 24 publications

Facilitation of the arterial baroreflex by the preoptic area in anaesthetized rats.

Facilitation of the arterial baroreflex by the preoptic area in anaesthetized rats.

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear

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