Projections from the spinal trigeminal nucleus to the cochlear nucleus in the rat

Haenggeli, Charles André; Pongstaporn, Tan; Doucet, John R.; Ryugo, David K.

doi:10.1002/cne.20466

Cited by 88 publications

(107 citation statements)

References 71 publications

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“…Since the excitatory CN-commissural pathway resembles that of non-auditory (somatosensory) projection neurons (Dehmel et al 2008;Haenggeli et al 2005;Wright and Ryugo 1996;Zhou et al 2007;Zhou and Shore 2004), it is likely to have a similar modulatory function as suggested for these non-auditory projections and may be associated with DCN synaptic plasticity under normal-hearing conditions (Tzounopoulos et al 2004;Young et al 1995;Zhou et al 2007). …”

Section: Discussionmentioning

confidence: 99%

“…(2) The locations in the GCD, and morphology of the excitatory CN-commissural terminal endings, as well as their immunoreactivity to VGLUT2 and not to VGLUT1, resemble that of non-auditory (somatosensory) projection neurons (Haenggeli et al 2005;Wright and Ryugo 1996;Zhou et al 2007;Zhou and Shore 2004). These non-auditory pathways can indirectly modulate DCN activity via parallel fibers, which can be either excitatory or inhibitory Davis et al 1996).…”

Section: Discussionmentioning

confidence: 99%

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Vesicular Glutamate Transporter 2 Is Associated with the Cochlear Nucleus Commissural Pathway

Zhou

Zeng

Cui

et al. 2010

JARO

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The cochlear nucleus (CN) is the first auditory structure to receive binaural information via CN-commissural connections. In spite of an abundance of evidence that CN-commissural neurons are glycinergic and thus inhibitory, physiological, and anatomical evidence suggests that a small group of CN-commissural neurons are excitatory. In this study, we examined the excitatory portion of the CN-commissural pathway by combining anterograde tract tracing with immunohistochemistry of vesicular glutamate transporters (VGLUTs) and retrograde tract tracing with immunohistochemistry of glycine and GABA. VGLUTs accumulate glutamate in synaptic vesicles and are prime markers for glutamatergic neurons. The terminal endings of CN-commissural projections were typically en passant or small terminal boutons, but large, irregular swellings were also observed, confined to the granule cell domain (GCD). Both small and large terminal endings in the GCD colabeled with VGLUT2, but not VGLUT1. In addition, some CN-commissural cells themselves received VGLUT2-positive puncta on their somata. After large injections into the CN, 37% of the total number of retrogradely labeled commissural neurons was immunonegative to glycine or GABA. Retrograde labeling after a restricted GCD injection revealed a majority of putative excitatory CN-commissural neurons as multipolar, in the marginal regions of the ventral CN, medially as well as in the small cell cap region and deep dorsal CN. These results provide direct anatomical evidence that an excitatory commissural projection is present, and VGLUT2 is associated with this pathway both as its source and as a recipient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vesicular Glutamate Transporter 2 Is Associated with the Cochlear Nucleus Commissural Pathway

Zhou

Zeng

Cui

et al. 2010

JARO

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“…What is the best explanation for such facilitation in an early response period dominated primarily by thalamocortical inputs? There is ample evidence that subcortical auditory structures such as the dorsal cochlear nucleus (DCN) (Zhou and Shore, 2004;Haenggeli et al, 2005;Shore, 2005;Shore et al, 2008), the inferior colliculus (IC) (Jain and Shore, 2006;Zhou and Shore, 2006), and the medial division of the thalamic medial geniculate nucleus (mMGN) (Poggio and Mountcastle, 1960;Blum et al, 1979;Nicolelis et al, 1991) all receive significant somatosensory inputs and show multisensory responses. Thus, these structures, in turn, may influence subcortical somatosensory structures such as the trigeminal nucleus (TN) and the thalamic ventral posterior medial nucleus (VPM).…”

Section: Discussionmentioning

confidence: 99%

Cross-Sensory Modulation of Primary Sensory Cortex Is Developmentally Regulated by Early Sensory Experience

Ghoshal¹,

Tomarken²,

Ebner³

2011

J. Neurosci.

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The presence of cross-sensory influences on neuronal responses in primary sensory cortex has been observed previously using several different methods. To test this idea in rat S1 barrel cortex, we hypothesized that auditory stimuli combined with whisker stimulation ("cross-sensory" stimuli) may modify response levels to whisker stimulation. Since the brain has been shown to have a remarkable capacity to be modified by early postnatal sensory activity, manipulating postnatal sensory experiences would be predicted to alter the degree of cross-sensory interactions. To test these ideas, we raised rats with or without whisker deprivation and with or without postnatal exposure to repeated auditory clicks. We recorded extracellular responses under urethane anesthesia from barrel cortex neurons in response to principal whisker stimulation alone, to auditory click stimulation alone, or to a cross-sensory stimulus. The responses were compared statistically across different stimulus conditions and across different rearing groups. Barrel neurons did not generate action potentials in response to auditory click stimuli alone in any rearing group. However, in cross-sensory stimulus conditions the response magnitude was facilitated in the 0 -15 ms post-whisker-stimulus epoch in all rearing conditions, whereas modulation of response magnitude in a later 15-30 ms post-whisker-stimulus epoch was significantly different in each rearing condition. The most significant cross-sensory effect occurred in rats that were simultaneously whisker deprived and click reared. We conclude that there is a modulatory type of cross-sensory auditory influence on normal S1 barrel cortex, which can be enhanced by early postnatal experiences.

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“…This type of tinnitus derives from complex somatosensory-auditory interactions and cross-modal mechanisms that mainly arise from musculoskeletal anatomical regions such as the temporomandibular joint (TMJ), craniocervical junction, cervical vertebrae, and neck and shoulder muscles (NECK) [Chan and Reade, 1994;Levine et al, 2003;Abel and Levine, 2004;Tullberg and Ernberg, 2006;Björne, 2007;Bernhardt et al, 2011;Vielsmeier et al, 2012;Buergers et al, 2014]. Animal studies have shown that projections from the auditory nerve and trigeminal and dorsal column ganglia and brainstem nuclei integrate in the cochlear dorsal nucleus [Haenggeli et al, 2005;Zhan et al, 2006;Dehmel et al, 2008;Wu et al, 2014]; furthermore, nonacoustic stimulation can modulate both the firing rates and temporal response patterns to the acoustic stimulation in the inferior colliculus, which receives inputs from the dorsal cochlear nucleus and the somatosensory nuclei [Zhou and Shore, 2006].…”

Section: Introductionmentioning

confidence: 99%

Somatosensory Tinnitus: Correlation between Cranio-Cervico-Mandibular Disorder History and Somatic Modulation

et al. 2016

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In a subpopulation of patients, tinnitus can be modulated by movements of the jaw or head and neck due to complex somatosensory-auditory interactions. In some of these subjects, tinnitus could be related to an underlying temporomandibular (TMJ) or craniocervical (NECK) dysfunction that, if correctly identified, could streamline treatment and increase chances of tinnitus improvement. However, it is still unclear whether somatic modulation of tinnitus could be used as a screening tool for identifying such patients. In this study, we included 310 tinnitus patients with normal hearing, no psychiatric comorbidities, and a positive history of TMJ and/or NECK dysfunction and/or a positive modulation of tinnitus to evaluate the characteristics of somatic modulation, investigate the relationship between positive history and positive modulation, and identify factors most strongly associated with somatic modulation. Tinnitus modulation was present in 79.67% of the patients. We found a significant association within the same subjects between a positive history and a positive tinnitus modulation for the same region, mainly for TMJ in unilateral tinnitus patients and for TMJ + NECK in bilateral tinnitus patients. A strong correlation between history and modulation in the same somatic region within the same subgroups of subjects was also identified. Most TMJ maneuvers resulted in an increased loudness, while NECK maneuvers showed an increase in tinnitus loudness in about 59% of cases. High-pitched tinnitus and male gender were associated with a higher prevalence of modulation; no differences were found for tinnitus onset, Tinnitus Handicap Inventory score, and age. In this paper, we report a strong association between history and modulation for the same regions within the same patients; such an association should always be investigated to improve chances of a correct diagnosis of somatosensory tinnitus.

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Projections from the spinal trigeminal nucleus to the cochlear nucleus in the rat

Cited by 88 publications

References 71 publications

Vesicular Glutamate Transporter 2 Is Associated with the Cochlear Nucleus Commissural Pathway

Vesicular Glutamate Transporter 2 Is Associated with the Cochlear Nucleus Commissural Pathway

Cross-Sensory Modulation of Primary Sensory Cortex Is Developmentally Regulated by Early Sensory Experience

Somatosensory Tinnitus: Correlation between Cranio-Cervico-Mandibular Disorder History and Somatic Modulation

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