Projection of morbidity and mortality due to breast cancer between 2020 and 2050 across 42 low- and middle-income countries

Rauniyar, Santosh Kumar; Hashizume, Masahiro; Yoneoka, Daisuke; Nomura, Shuhei

doi:10.1016/j.heliyon.2023.e16427

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Breast cancer (BC) is the most common diagnosed cancer worldwide with 2.3 million new cases in 2020 (11.7% of all new cancer cases) and 685,000 deaths [ 1 ]. By 2040, an annual reduction of 2.5% in global BC mortality is expected [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Heart rate variability-based prediction of early cardiotoxicity in breast-cancer patients treated with anthracyclines and trastuzumab

Luna-Alcala,

Espejel-Guzmán,

Lerma

et al. 2024

Cardio-Oncology

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Background Cardiotoxicity is a recognized complication in breast cancer (BC) patients undergoing chemotherapy with anthracyclines with or without trastuzumab. However, the prognostic value of heart rate variability (HRV) indexes for early cardiotoxicity development remains unknown. Methods Fifty BC patients underwent TTE assessment before and three months after chemotherapy. HRV indexes were obtained from continuous electrocardiograms in supine position with spontaneous breathing, active standing, and supine position with controlled breathing. The magnitude of change (Δ) between supine-standing and supine-controlled breathing was calculated. Variables were compared using t-test or ANOVA. Cardiotoxicity predictive value was assessed by ROC curve analysis. A p value of < 0.05 was considered significant. Results TTE revealed reduced left atrial conduit strain in the cardiotoxicity group. Mean heart rate increased during all maneuvers at follow-up, with no differences in HRV indexes between patients with or without cardiotoxicity. However, a lower Δ in supine-controlled breathing of several HRV indexes predicted early cardiotoxicity identified by echocardiography (e.g. SDNN ≤ -8.44 ms: Sensitivity = 75%, Specificity = 69%). Conclusions BC patients treated with chemotherapy maintain cardiac autonomic responses to physiological stimuli after 3 months of chemotherapy. However, a lower Δ during active standing and controlled breathing before chemotherapy may predict early cardiotoxicity.

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Section: Introductionmentioning

confidence: 99%