Projecting the 10-year costs of care and mortality burden of depression until 2032: a Markov modelling study developed from real-world data

Chan, Vivien Kin Yi; Leung, Man Yee Mallory; Chan, Sandra Sau Man; Yang, Deliang; Knapp, Martin; Luo, Hao; Craig, Dawn; Chen, Yingyao; Bishai, David Makram; Wong, Gloria Hoi Yan; Lum, Terry Yat Sang; Chan, Esther Wai Yin; Wong, Ian Chi Kei; Li, Xue

doi:10.1016/j.lanwpc.2024.101026

Cited by 1 publication

(1 citation statement)

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“…Despite considerable advances in pharmacology and therapy techniques, the general population prevalence of depression has not declined [ 5 , 6 ]. In 2019, it was estimated that depressive disorders affected 280 million people [ 7 ]. The prevalence of depressive disorders varies across the world, but the 12-month prevalence estimated by the World Health Organization, World Mental Health (WHO, WMH) survey ranged from 2.2% to 10.4%, with a median of 5% across all countries [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults

Jahan-Mihan,

Stevens,

Medero-Alfonso

et al. 2024

Nutrients

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Depression is a major global health concern expected to worsen by 2030. In 2019, 28 million individuals were affected by depressive disorders. Dietary and supplemental vitamins show overall favorable preventative and therapeutic effects on depression. B vitamins are crucial for neurological function and mood regulation. Deficiencies in these vitamins are linked to depression. Studies on individual B vitamins show promise in improving depressive symptoms, particularly thiamin, riboflavin, niacin, and folate. Vitamin C deficiency may heighten depressive symptoms, but its exact role is not fully understood. Seasonal Affective Disorder (SAD) is associated with insufficient sunlight exposure and vitamin D deficiency. Vitamin D supplementation for SAD shows inconsistent results due to methodological variations. Further investigation is needed to understand the mechanisms of vitamins in depression treatment. Moreover, more research on SAD and light therapy’s efficacy and underlying mechanisms involving photoreceptors, enzymes, and immune markers is needed. Although dietary and supplemental vitamins show overall favorable preventative and therapeutic effects on depression, dietitians treating psychiatric disorders face challenges due to diverse study designs, making direct comparisons difficult. Therefore, this article reviews the current literature to assess the role of dietary and supplemental vitamins in the prevention and treatment of depression. This review found that, although evidence supports the role of B vitamins and vitamins C and D in preventing and treating depression, further research is needed to clarify their mechanisms of action and determine the most effective intervention strategies.

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