The present research examined cultural differences in interpersonal memories and forecasts, situated in a currently salient positive or negative interpersonal context. We found that a negative focal event, compared to a positive one, led to more negative memories and forecasts of interpersonal encounters. The effect was stronger among Euro-Canadians than among Chinese. This was true regardless of whether the salient focal event was imagined or a real-life experience. Furthermore, focal thinking—the extent to which individuals think about the salient focal event—mediated cultural differences in interpersonal memories and forecasts as moderated by the focal event valence. Relational memories and forecasts positively predicted perceived relationship quality, willingness to help, and forgiveness. The findings highlight both cultural similarities and differences in interpersonal memories and forecasts, which contribute significantly to the literature on culture and relationships.