Projected 24-hour post-dose ocular itching scores post-treatment with olopatadine 0.7% versus 0.2%

Fidler, Matthew; Ogundele, Abayomi; Covert, David; Sarangapani, Ramesh

doi:10.1007/s10928-018-9588-7

Cited by 3 publications

(4 citation statements)

References 20 publications

(24 reference statements)

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“…Importantly, the differential odds model can collapse into the proportional odds model, if differential odds are not supported by the data. This flexibility has shown to be valuable in analyzing sedation data (24)(25)(26) and ocular itching scores (27).…”

Section: Mixed-effects Logistic Modelingmentioning

confidence: 99%

Sweet/Fat Preference Taste in Subjects Who are Lean, Obese and Very Obese

Leohr

Kjellsson

2020

Pharm Res

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Purpose This study assessed the perception of sweetness, creaminess, and pleasantness from a sweet/fat preference test in subjects who are lean (BMI: 19–25), obese (BMI: 30–33) or very obese (BMI: 34–40) using categorical modeling. Methods Subjects tasted 16 dairy solutions consisting of 0%, 3.5%, 11.3% and 37.5% fat and each containing 0%, 5%, 10%, or 20% sugar and rated them for sweetness, creaminess and pleasantness. Results A proportional odds model described the perception of sweetness using an Emax for the effect of sugar and a linear effect for fat. Perception of creaminess was dependent on the fat and sugar content and was described with proportional odds model with linear effects of sugar and fat. Perception of pleasantness increased with sugar and fat but decreased in solutions containing 37.5% fat. A differential odds model using an Emax model for fat and sugar with a negative interaction between them allowed the sugar content to be less than proportional and the fat content to be greater than proportional for pleasantness. Conclusions Application of modeling provided understanding of these complex interactions of sugar and fat on the perception of sweetness, creaminess, and pleasantness and provides a tool to investigate obesity and pharmacological intervention.

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Section: Mixed-effects Logistic Modelingmentioning

confidence: 99%

Sweet/Fat Preference Taste in Subjects Who are Lean, Obese and Very Obese

Leohr

Kjellsson

2020

Pharm Res

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“…The models are hierarchical as the differential odds model can collapse into the proportional odds model. The differential odds model has been shown to improve analysis of sedation data [14][15][16] and ocular itching scores [17].…”

Section: Introductionmentioning

confidence: 99%

Linking categorical models for prediction of pleasantness score using individual predictions of sweetness and creaminess: An advancement of categorical modeling

Leohr

Kjellsson

2021

J Pharmacokinet Pharmacodyn

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The aim of this work was to develop and evaluate approaches of linked categorical models using individual predictions of probability. A model was developed using data from a study which assessed the perception of sweetness, creaminess, and pleasantness in dairy solutions containing variable concentrations of sugar and fat. Ordered categorical models were used to predict the individual sweetness and creaminess scores and these individual predictions were used as covariates in the model of pleasantness response. The model using individual predictions was compared to a previously developed model using the amount of fat and sugar as covariates driving pleasantness score. The model using the individual prediction of odds of sweetness and creaminess had a lower variability of pleasantness than the model using the content of sugar and fat in the test solutions, which indicates that the individual odds explain part of the variability in pleasantness. Additionally, simultaneous and sequential modeling approaches were compared for the linked categorical model. Parameter estimation was similar, but precision was better with sequential modeling approaches compared to the simultaneous modeling approach. The previous model characterizing the pleasantness response was improved by using individual predictions of sweetness and creaminess rather than the amount of fat and sugar in the solution. The application of this approach provides an advancement within categorical modeling showing how categorical models can be linked to enable the utilization of individual prediction. This approach is aligned with biology of taste sensory which is reflective of the individual perception of sweetness and creaminess, rather than the amount of fat and sugar in the solution.

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“…6 Both actions prevent the effects of histamine on capillaries, thereby preventing histamine-induced pain and itching of mucous membranes. 7,8 In this work, HCl was selected due to its therapeutic potential reported in literature. 7,8 The developed formulation was characterized for various in vitro parameters such as swelling ratio, drug contents, and in vitro properties such as drug release and ocular irritation.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 In this work, HCl was selected due to its therapeutic potential reported in literature. 7,8 The developed formulation was characterized for various in vitro parameters such as swelling ratio, drug contents, and in vitro properties such as drug release and ocular irritation. The ocular irritation of the formulation was evaluated to assess its potential as an ophthalmic drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and evaluation of Olopatadine hydrochloride ocular inserts

Qureshi

Iqbal

Hussain

et al. 2020

Journal of Plastic Film & Sheeting

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Development of the novel delivery provides optimal drug delivery via facilitated transcorneal penetration and ultimately improved retention time in eye. The present study was to fabricate and evaluate the performance of ocular inserts of Olopatadine hydrochloride by consuming polymers such as hydroxypropyl methylcellulose, gelatin, and chitosan at various concentrations with different plasticizers using solvent casting technique. Prepared formulations were evaluated for thickness, weight variations, drug content, surface pH, swelling studies, and in vitro drug release. Fourier transform infrared spectroscopy studies showed that interaction occurred between polymer and drug, and successful drug entrapment occurred in the matrix. All formulations showed excellent film-forming capacity with good thickness and weight uniformity. Folding endurance proved that the inserts were soft, elastic, and flexible. Chitosan-based ocular inserts showed greater swelling index as compared to gelatin and hydroxypropyl methylcellulose inserts. In vitro studies showed prolonged drug release and followed zero-order kinetic model and non-Fickian drug release.

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Projected 24-hour post-dose ocular itching scores post-treatment with olopatadine 0.7% versus 0.2%

Cited by 3 publications

References 20 publications

Sweet/Fat Preference Taste in Subjects Who are Lean, Obese and Very Obese

Sweet/Fat Preference Taste in Subjects Who are Lean, Obese and Very Obese

Linking categorical models for prediction of pleasantness score using individual predictions of sweetness and creaminess: An advancement of categorical modeling

Fabrication and evaluation of Olopatadine hydrochloride ocular inserts

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