Project management in laboratory medicine

Lippi, Giuseppe; Mattiuzzi, Camilla

doi:10.2478/jomb-2019-0021

Cited by 17 publications

(16 citation statements)

References 23 publications

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“…Clinical laboratories, even the most recently constructed, have been designed and organized to sustain a limited (i.e. "customized") volume of tests [20], so recruiting human and technical resources for facing unexpected health crises would not be so easy at the down of the third millennium. Laboratory automation, availability of high-throughput instrumentation [21], along with lower number of employees and reduced healthcare funding (especially for public facilities) have all contributed to considerably reduce the flexibility to develop emergent responses [22].…”

Section: Organizational Issuesmentioning

confidence: 99%

The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks

Lippi

Plebani

2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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329

269

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AbstractCoronavirus disease 2019, abbreviated to COVID-19 and sustained by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the latest biological hazard to assume the relevance of insidious worldwide threat. One obvious question that is now engaging the minds of many scientists and healthcare professionals is whether and eventually how laboratory medicine could efficiently contribute to counteract this and other (future) viral outbreaks. Despite there being evidence that laboratory tests are vital throughout many clinical pathways, there are at least three major areas where in vitro diagnostics can also provide essential contributions to diagnostic reasoning and managed care of patients with suspected or confirmed SARS-CoV-2 infection. These include etiological diagnosis, patient monitoring, as well as epidemiologic surveillance. Nonetheless, some structural and practical aspects may generate substantial hurdles in providing timely and efficient response to this infectious emergency, which basically include inadequate (insufficient) environment and shortage of technical and human resources for facing enhanced volume of tests on many infected patients, some of whom are with severe disease. Some proactive and reactive strategies may hence be identified to confront this serious healthcare challenge, which entail major investments on conventional laboratory resources, reinforcement of regional networks of clinical laboratories, installation of mobile laboratories, as well as being proactive in establishing laboratory emergency plans.

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Section: Organizational Issuesmentioning

confidence: 99%

The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks

Lippi

Plebani

2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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329

269

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“…Establishing RIs by recruiting healthy individuals is a direct sampling method, which is costly and time-consuming (10,13,14). First described in 1963 (15), indirect sampling must include a large number of normal individual records from databases, which is based on data mining techniques, cost-effective, and easier to perform in less time with lower material resources (7,16) compared to direct sampling methods.…”

Section: Introductionmentioning

confidence: 99%

Gender- and age-specific reference intervals of common biochemical analytes in chinese population – derivation using real laboratory data

Wang

Zou

et al. 2019

Journal of Medical Biochemistry

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Summary Background Indirect sampling methods are not only inexpensive but also efficient for establishing reference intervals (RIs) using clinical data. This study was conducted to select fully normal records to establish age- and gender-specific RIs for common biochemical analytes by laboratory data mining. Methods In total, 280,206 records from 2014 to 2018 were obtained from Peking Union Medical College Hospital. Common biochemical analytes [total protein, albumin, total bilirubin (TBil), direct bilirubin (DBil), alanine aminotransferase (ALT), glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), potassium, sodium, chlorine, calcium, urea, glucose, uric acid (UA), inorganic phosphorus, creatinine (Cr), total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol] were measured using an automatic analyzer. Sources of variation were identified by multiple regression analysis. The 2.5th and 97.5th percentiles were calculated as the lower and upper limits of the RIs, respectively. Results Metode indirektnog uzorkovanja nisu samo jeftine, već su i efikasne za uspostavljanje referentnih intervala (RI) korišćenjem velike količine kliničkih podataka. Ova studija je sprovedena sa ciljem da se odaberu potpuno normalni pojedinačni zapisi da bi se utvrdio RI za starost i pol za zajedničke biohemijske analite pomoću laboratorijski dobijenih podataka. Conclusions Ukupno je uzeto 280.206 pojedinačnih rezultata u periodu od 2014. do 2018. godine iz bolnice Peking Union Medical College-a. Uobičajeni biohemijski analiti [ukupni protein, albumin, ukupni bilirubin (TBil), direktni bilirubin (DBil), alanin aminotransferaza (ALT), glutamiltranspeptidaza (GGT), alkalna fosfataza (ALP), aspartat aminotransferaza (AST), laktat dehidrogenaza (LAT) kalijum, natrijum, hlor, kalcijum, ureja, glukoza, mokraćna kiselina (UA), neorganski fosfor, kreatinin (Cr), ukupni hole sterol, trigliceridi, lipoprotein holesterola visoke gustine i lipoprotein holesterola niske gustine] mereni su korišćenjem automatskog analizatora. Izvori varijacije identifikovani su višestrukom regresionom analizom. Postoci (2,5 i 97,5) su izračunati kao donja i gornja granica RI, svaki ponaosob.

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“…Patient safety related to patient identification is a controllable challenge in all types of blood collection procedures (15). However, in this study, the most challenging steps of the phlebotomy procedure were patient identification and inversion of the tubes for a sufficient number of times.…”

Section: Discussionmentioning

confidence: 87%

The results of a close follow-up of trainees to gain a good blood collection practice

Aykal

Esen

Yeğin

et al. 2019

Journal of Medical Biochemistry

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Summary Background Phlebotomy is one of the most important steps in the preanalytical phase of a clinical laboratory process. In order to decrease phlebotomy errors, this specific procedure should be taught in detail by laboratory organizations. Our study aims to practice the training program on venous blood sampling and observe the close follow-up results. Methods In this observational study, 127 students who started their summer internship in Antalya Education and Research Hospital were given a one-day theoretical phlebotomy training in accordance with the Venous Blood Sampling Guidelines. After the theoretical training, phlebotomy applications of 10 students who were working in the field of out-patient blood sampling were observed both with and without their knowledge. A comprehensive checklist related to phlebotomy was created by the trainers in Antalya Education and Research Hospital and the observers answered each question as yes or no. For the statistical analysis, IBM SPSS Statistics 21.0 was used. Results After the theoretical education, the trainees were observed but no significant difference was found between the first and the second informed observations (p = 0.125). The students were observed three times more in the following week without their knowledge. There was a statistically significant difference between the first and the third unannounced observations (p=0.001). Conclusions In order to perform phlebotomy correctly, apart from theoretical education, a close follow-up is necessary too.

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Project management in laboratory medicine

Cited by 17 publications

References 23 publications

The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks

The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks

Gender- and age-specific reference intervals of common biochemical analytes in chinese population – derivation using real laboratory data

The results of a close follow-up of trainees to gain a good blood collection practice

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