Project-based learning course on metabolic network modelling in computational systems biology

Abstract

Project-based learning (PBL) is a dynamic student-centred teaching method that encourages students to solve real-life problems while fostering engagement and critical thinking. Here, we report on a PBL course on metabolic network modelling that has been running for several years within the Master in Integrated Systems Biology (MISB) at the University of Luxembourg. This 2-week full-time block course comprises an introduction into the core concepts and methods of constraint-based modelling (CBM), applied to toy models and large-scale networks alongside the preparation of individual student projects in week 1 and, in week 2, the presentation and execution of these projects. We describe in detail the schedule and content of the course, exemplary student projects, and reflect on outcomes and lessons learned. PBL requires the full engagement of students and teachers and gives a rewarding teaching experience. The presented course can serve as a role model and inspiration for other similar courses.

Research-driven education: An introductory course to systems and synthetic biology

“…nwo.nl/en/projects/022004006-0 and https://gow.epsrc.ukri.org/ NGBOViewGrant.aspx?GrantRef=EP/L016494/1) have supported the creation of training centers for early career researchers, where students can follow courses covering fundamental topics in experimental and theoretical spheres of Systems and Synthetic Biology. At the academic level, educators have also described how problem-based learning and flipped classrooms can be used effectively to simulate computational biology research assuming that experimental data has already been obtained (Robeva and Laubenbacher, 2009;Eager, Peirce and Barlow, 2014;Sauter et al, 2022).…”