Abstract:New-onset HLA-DR-associated anti-citrullinated protein autoantibody (ACPA)+ rheumatoid arthritis (RA) synovial tissue (ST) contains highly-expanded TCR-αβ clonotypes, some viral-antigen-reactive. However, it is unknown how viral-specific T-cells sustain ACPA+ RA. We studied paired peripheral blood (PB) and ST TCR repertoires in drug-naïve ACPA+ HLA-DRB1*04:01+ diffuse-myeloid RA ST pathology. To model effects of viral infection, we induced ovalbumin antigen-induced arthritis (AIA) in mice with latent murine-cy… Show more
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