Proinflammatory high‐density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis

Abstract

Objective. Women with systemic lupus erythematosus (SLE) have a 7-50-fold increased risk of coronary artery disease (CAD). In the general population, oxidized low-density lipoprotein (ox-LDL) increases the risk for CAD. Normal high-density lipoproteins (HDLs) protect LDL from oxidation; proinflammatory HDLs do not. This study was undertaken to determine whether patients with SLE, who have chronic inflammation that causes oxidative damage, have more proinflammatory HDL and higher levels of ox-LDL, thus predisposing them to atherosclerosis.Methods. One hundred fifty-four women with SLE, 48 women with rheumatoid arthritis (RA), and 72 healthy controls were studied. The ability of the patients' HDL to prevent oxidation of normal LDL was measured. Values >1.0 (the value assigned for LDL oxidation in the absence of HDL) after the addition of HDL indicated proinflammatory HDL. Plasma ox-LDL levels were measured as the amount of oxidation produced by the patient's LDL after the removal of HDL. Conclusion. HDLs are proinflammatory in a significant proportion of SLE patients and are associated with elevated levels of ox-LDL. Abnormal HDLs impair the ability to prevent LDL oxidation and may predispose to atherosclerosis. Results. SLE patients had more proinflammatory HDL (mean

Induction of Scavenger Receptor Class B Type I Is Critical for Simvastatin Enhancement of High-Density Lipoprotein-Induced Anti-Inflammatory Actions in Endothelial Cells

“…Changes in plasma lipid profiles, particularly low levels of HDL, are associated with several inflammatory and immune diseases in addition to atherosclerosis, including rheumatoid arthritis (3), systemic lupus erythematosus (4), Sjögren's syndrome (5), and ankylosing spondylitis (6). In some cases of these diseases, abnormal or proinflammatory HDL is accumulated (7). Reverse cholesterol transport is known to be an important mechanism allowing HDL to prevent the accumulation of cholesterol in leukocytes and the formation of foam cells in the intima of vessel walls (1,2).…”

Dysfunctional HDL: From Structure-Function-Relationships to Biomarkers

“…HDL loses potential antiatherosclerotic properties in patients with chronic inflammatory disorders, such as the antiphospholipid syndrome (Charakida et al 2009), systemic lupus erythematosus and rheumatoid arthritis (McMahon et al 2006), scleroderma (Weihrauch et al 2007), metabolic syndrome (de Souza et al 2008), diabetes (Persegol et al 2006;Sorrentino et al 2010), and CAD (Ansell et al 2003;Besler et al 2011;. In a study of 189 patients with chronic kidney disease on hemodialysis, an impaired anti-inflammatory capacity of HDL was correlated with a poor clinical outcome (Kalantar-Zadeh et al 2007).…”

Ürik Asidin Antioksidan ve Pro-Oksidan Özellikleri ile İlgili Kavram ve Tartışmalarının Derlemesi

“…Oxidative stress, which is defined as an imbalance between the pro-oxidant reactive species and antioxidant molecules, both endogenous and exogenous, has been associated with many non-communicable diseases, such as obesity, insulin resistance 10 and diabetes 11 , atherosclerosis 12,13 , autoimmune diseases 14,15 , neurodegenerative diseases 16,17 , chronic renal disease 18,19 , different malignancies 20,21 , as well as in aging 22 as a physiological process.…”