Proinflammatory effects and mechanisms of calprotectin on human gingival fibroblasts

Gao, Hongyu; Hou, Jianjun; Meng, Hua; Zhang, X.; Zheng, Yi; Peng, Lirong

doi:10.1111/jre.12465

Cited by 27 publications

(20 citation statements)

References 44 publications

(87 reference statements)

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“…Recent studies have identified S100A9 as a ligand of the receptor for advanced glycation end products (RAGE), which plays a regulatory role in pro-inflammatory responses 25 , 26 . Moreover, S100A9 has been shown to be closely related to the MAPK signaling pathway, which promotes cancer development and tumor spread via inflammatory pathways 8 , 27 ; however, the mechanism underlying the regulatory role of S100A9 in SM progression was unclear.…”

Section: Discussionmentioning

confidence: 99%

LINC00852 Promotes Lung Adenocarcinoma Spinal Metastasis by Targeting S100A9

et al. 2018

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Background: Lung adenocarcinoma has a strong tendency to develop into bone metastases, especially spinal metastases (SM). Long noncoding RNAs (lncRNAs) play critical roles in regulating several biological processes in cancer cells. However, the mechanisms underlying the roles of lncRNAs in the development of SM have not been elucidated to date.Methods: Clinical specimens were collected for analysis of differentially expressed lncRNAs. The Kyoto Encyclopedia of Genes and Genomes (KEGG) was used to examine the effects of these genes on pathways. RNA pull-down was utilized to identify the targeting protein of lncRNAs. The effects of lncRNA on its target were detected in A549 and SPCA-1 cells via perturbation of the lncRNA expression. Oncological behavioral changes in transfected cells and phosphorylation of kinases in the relevant pathways, with or without inhibitors, were observed. Further, tumorigenicity was found to occur in experimental nude mice.Results: LINC00852 and the mitogen-activated protein kinase (MAPK) pathway were found to be associated with SM. Moreover, the LINC00852 target S100A9 had a positive regulatory role in the progression, migration, invasion, and metastasis of lung adenocarcinoma cells, both in vitro and in vivo. Furthermore, S100A9 strongly activated the P38 and REK1/2 kinases, and slightly activated the phosphorylation of the JNK kinase in the MAPK pathway in A549 and SPCA-1 cells.Conclusion: LINC00852 targets S100A9 to promote progression and oncogenic ability in lung adenocarcinoma SM through activation of the MAPK pathway. These findings suggest a potential novel target for early intervention against SM in lung cancer.

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Section: Discussionmentioning

confidence: 99%

LINC00852 Promotes Lung Adenocarcinoma Spinal Metastasis by Targeting S100A9

et al. 2018

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“…In response to TLR4 stimulation, S100A9-deficient neutrophils exhibited impaired production of cytokines ( 75 ). S100A9 and S100A8/A9 significantly upregulated IL-6 and IL-8 expression in human gingival fibroblasts via the S100A9 subunit ( 76 ). (Figure 1 demonstrates the S100A8/A9-induced inflammation signaling pathway involved in TLR4, MyD88, and MAPKs.)…”

Section: Biological Functions Of S100a8/a9mentioning

confidence: 99%

S100A8/A9 in Inflammation

et al. 2018

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S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.

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“…1 HLA-B 57 was identified as an independent resistance indicator for generalized periodontitis. 3 Apart from this finding, HLA-B57.01-positivity, affecting ∼5 to 11% of the Caucasian population, was identified as major risk factor for development of the abacavir-hypersensitivity reaction. 11,12 Abacavir is a guanosine-analogue, broadly used as a reverse transcriptase inhibitor in antiretroviral combination therapy.…”

mentioning

confidence: 98%

“…This results in a different binding capacity of bacterial peptides on the paratops of various HLA alleles . HLA‐B 57 was identified as an independent resistance indicator for generalized periodontitis . Apart from this finding, HLA‐B57.01‐positivity, affecting ∼5 to 11% of the Caucasian population, was identified as major risk factor for development of the abacavir‐hypersensitivity reaction .…”

mentioning

confidence: 99%