Proinflammatory cytokines in early childhood caries: Salivary analysis in the mother/children pair

Ribeiro, Cecília Cláudia Costa; Pachêco, Crysthian de Jesus Borges; Costa, Elizabeth Lima; Ladeira, Lorena Lúcia Costa; Costa, José Ferreira; Silva, Rubenice Amaral da; Carmo, Cadidja Dayanne Sousa

doi:10.1016/j.cyto.2017.12.009

Cited by 21 publications

(16 citation statements)

References 20 publications

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“…ECC leads to pain when not managed, and the pain contributes to poor feeding, nutrient deficiency [2][3][4] and growth failure (underweight, stunted and wasted) [5,6]. Also, children with ECC have high levels of proinflammatory cytokines [7], which trigger a cascade of inflammatory processes [8] associated with impaired growth and obesity inducing mechanisms [9]. Obesity and stunting also cause changes in the salivary glands and the composition of saliva, which increases the risk for ECC by lowering salivary pH [10].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Recent emerging evidence suggest that children with ECC have higher levels of pro-inflammatory cytokines [8]. Cytokines act as mediators of inflammation, infection and immunological processes [29] and they increase with increased severity of ECC [8]. The pro-inflammatory cytokines produces free radicals that generate peroxides, Prostaglandin E2, interleukin 6, tumour necrotizing factor -alpha and cysteinyl leukotrienes -powerful agents in the inflammatory response [30] -which are significantly associated with increased nutritional risk [31].…”

Section: Introductionmentioning

confidence: 99%

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Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria

Foláyan¹,

Arije

Tantawi

et al. 2019

Preprint

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Background : To determine the association between malnutrition and early childhood caries (ECC) in children resident in sub-urban, Nigeria. Methods : This study is a secondary analysis of a larger cross-sectional data generated through a household survey. Variables (sex, frequency of sugar consumption, maternal knowledge of oral hygiene, oral hygiene status) associated with ECC in the primary study conducted in the Ile-Ife, Nigeria, were adjusted for in the models. We used Poisson regression analysis to determine the association between ECC and malnutrition (stunting, overweight and underweight). We reported the adjusted prevalence ratio (APR). Results: Of the 370 children, 20 (5.41%) were underweight, 20 (5.41%) were overweight, 67 (18.11%) were wasting, 120 (32.43%) were stunted and 18 (4.86%) had ECC. Factors associated with ECC were being stunted, underweight, overweight and fair oral hygiene. The prevalence of ECC was lower in children who were stunted (APR: 0.14; 95% CI: 0.03-0.69; p=0.02), almost seven times higher in children who were overweight (APR: 6.88; 95% CI: 1.83-25.85; p<0.001), and predictively absent in children who were underweight (APR: 0; 95% CI: 0-0; p<0.001) when compared with children who had normal weight. Non-significant risk indicators for ECC included consuming sugar between meals three times a day or more, having low socioeconomic status and being female. Conclusions : For this study population, the indicators of malnutrition – being stunted, underweight, overweight - and fair oral hygiene were risk indicators for ECC, while the frequency of sugar consumption was not a significant risk indicator. Further studies are needed to identify if there are other mediators of associations between ECC and nutrition status apart from sugar consumption.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria

Foláyan¹,

Arije

Tantawi

et al. 2019

Preprint

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“…The Luminex xMAP™ salivary assays were performed in 96-well plate. Analytes were preferred on pathophysiology cases which described in the literature (6).…”

Section: Multiplex Saliva Cytokines Analysismentioning

confidence: 99%

Salivary Pro-Inflammatory Cytokines and Salivary Bacterial Challenge Effect on Dental Caries: A Clinico-Molecular Cross-Sectional Study

Pakdemirli

Koçal

Kılınç

et al. 2020

J Basic Clin Health Sci

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Objectives: Objective of this study is to determine the correlation between salivary cytokine concentrations and cariogram value high (C1) and low (C2) experience in people. In this direction, saliva cytokines showed a significant correlation with the patient's caries experience. Patients and Methods: Unstimulated whole saliva samples were collected from 38 appropriate populations of patients aged between 20 to 57 years old. All patients' DMF (decay/missing/filled) values were higher than 0. Twenty-one caries activity groups (C1) and 17 caries nonactivity groups (C2) patients were collected for this study. Procedures of the clinical evaluation were the collection of saliva samples and oral examination. The whole saliva from 38 patients with C1 and C2 was investigated for the existence of GM-CSF,

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“…The role of saliva and its biological content has been extensively studied to discover its association with dental caries (16), and pro-inflammatory cytokines have been suggested to play a very important role in the immune system. Thus far, limited studies have considered the concentration of pro-inflammatory cytokines in dental caries (18,19), and it has been shown that TNF-α, IL-6, IL-8, and vascular endothelial growth factor (VEGF) are secreted more in saliva of individuals with active caries (19)(20)(21), although there was no relationship between dental caries and the serum and salivary levels of IL-1-β, IL-10, and antagonist IL-1 receptor (18). Also, no study has addressed the relationship between TNF-α levels and age, or compared children's immune response at different age groups and during adolescence.…”

Section: Introductionmentioning

confidence: 99%

Salivary Tumor Necrosis Factor-Alpha and Dental Caries in Children and Adolescents

Nazemisalman

Jafari²,

Esmaelzadeh

et al. 2018

Iran J Pediatr

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Background: Dental caries is one of the most common diseases during childhood. Saliva can modulate the process of decay, as a rich source of host factors. It has been shown that tumor necrosis factor-alpha (TNF-α) is secreted more in the saliva of individuals with active caries. No study has addressed the relationship between TNF-α levels and age or compared children's immune response at different age groups and during adolescence. Objectives: The present study aimed at evaluating the pro-inflammatory cytokine level of TNF-α in saliva and its association with caries in different age groups of children and adolescents. Methods: In this case-control study, 128 children and adolescents were divided to four age groups of 32. In each group, half of the individuals had no decay (control group) and the other half had > 4 decayed teeth (case group). Overall, 5 mL of non-stimulated saliva was spitted in sterile tubes for 15 minutes. Furthermore, 1 mL of each sample was centrifuged for five minutes at 12000 rpm. Salivary level of TNF-α was measured using the Enzyme Linked Immunosorbent Assay (ELISA) standard kit. Results: A total of 79 children were studied. The mean TNF-α levels in the case group was 35.20 ± 16.23 Pg/mL and in the control group, this was 26.20 ± 6.25 Pg/mL (P value = 0.001). The mean TNF-α level was significantly higher in the age group of six to 12 years than the age group of 13 to 18 years (P value = 0.01). Conclusions: The results of this study indicated that decay plays an important role in increasing cytokine TNF-α in non-stimulatory saliva, there is no confirming evidence of the direct effect of age on immune function yet.

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Proinflammatory cytokines in early childhood caries: Salivary analysis in the mother/children pair

Cited by 21 publications

References 20 publications

Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria

Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria

Salivary Pro-Inflammatory Cytokines and Salivary Bacterial Challenge Effect on Dental Caries: A Clinico-Molecular Cross-Sectional Study

Salivary Tumor Necrosis Factor-Alpha and Dental Caries in Children and Adolescents

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