Proinflammatory cytokines as serum biomarker in oral carcinoma—A prospective multi‐biomarker approach

Schiegnitz, Eik; Kämmerer, Peer W.; Schön, Holger; Blatt, Sebastian; Berres, Manfred; Sagheb, Keyvan; Al‐Nawas, Bilal

doi:10.1111/jop.12670

Cited by 26 publications

(32 citation statements)

References 26 publications

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“…When analyzing our overall data, we observed an association between good prognosis and HPV positivity, whereas adverse prognosis was associated with increasing both CRP levels and WBC counts. These are expected associations that have been described in previous studies [ 9 , 21 , 22 , 23 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 78 ] and therefore suggest that our patient cohort is representative. Furthermore, histopathological features like tumor lymphocyte density predict prognosis both in HPV-negative and HPV-positive oropharyngeal cancer patients [ 79 ].…”

Section: Discussionsupporting

confidence: 85%

“…Several previous studies have shown that both increased systemic CRP levels [ 8 , 47 , 48 , 49 , 50 , 51 , 52 ] and IL6 levels [ 9 , 21 , 22 , 23 , 53 , 54 , 55 , 56 , 57 ] are associated with an adverse prognosis in HNSCC. IL6 can function as a driver of the acute phase reaction, i.e., increased CRP levels can at least partly be due to an IL6 effect [ 1 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Systemic inflammatory responses, including the systemic levels of acute phase cytokines, have a prognostic impact in several cancers, including HNSCC [ 9 , 10 , 21 , 22 , 23 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. However, the acute phase reaction is an example of how several cytokines (including IL6 family and IL1 subfamily members as well as TNFα) form an interacting network [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

et al. 2020

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C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction inducers. In the present study, we compared the pretreatment acute phase cytokine profile for 144 patients with potentially curative HNSCC. We investigated the systemic levels of interleukin (IL)6 family mediators (glycoprotein (gp130), IL6 receptor (R)α, IL6, IL27, IL31, oncostatin M (OSM), ciliary neurotrophic factor (CNTF)), IL1 subfamily members (IL1R antagonist (A), IL33Rα), and tumor necrosis factor (TNF)α. Patient subsets identified from this 10-mediator profile did not differ with regard to disease stage, human papilloma virus (HPV) status, CRP levels, or death cause. Increased CRP, IL6, and IL1RA levels were independent markers for HNSCC-related death in the whole patient population. Furthermore, gp130, IL6Rα, and IL31 were suggested to predict prognosis among tumor HPV-negative patients. Only IL6 predicted survival in HPV-positive patients. Finally, we did a clustering analysis of HPV-negative patients based on six acute phase mediators that showed significant or borderline association with prognosis in Kaplan–Meier analyses; three subsets could then be identified, and they differed in survival (p < 0.001). To conclude, (i) HPV-negative and HPV-positive HNSCC patients show similar variations of their systemic acute phase profiles; (ii) the prognostic impact of single mediators differs between these two patient subsets; and (iii) for HPV-negative patients, acute phase profiling identifies three patient subsets that differ significantly in survival.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

et al. 2020

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“…Higher sensitivity and specificity were obtained by measuring the levels of both IL-6 and IL-8. [ 83 ]. Similarly, Punyani and Sathawane analysed the salivary level of IL-8 in patients with premalignant oral lesions and OSCC and in a control group.…”

Section: Markers Of Inflammation In Osccmentioning

confidence: 99%

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Tampa

Mitran

et al. 2018

Journal of Immunology Research

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Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation that could be useful in diagnosis and shed some light in OSCC pathogenesis.

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“…Other studies found that exogenous TNF-α induces the transition of inflammation in the tumor stroma [21]. On the other side, Schiegnitz et al [22] demonstrated that serum TNF-α level is not a useful associated or prognostic marker of oral squamous cell carcinoma patients as IL-6, IL-8, and soluble IL-2R. Conflicting results about the level of TNF-α relates to the methodology of each study.…”

Section: Discussionmentioning

confidence: 99%

Concomitant using of topical carrageenan-kappa and oral vitamin D against 7, 12-dimethylbenz[a]anthracene induced-oral cancer in rats: A synergism or an antagonism effects

Ali

Al-Juboori

Al-Nimer

2020

BDS

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Objective: κ-carrageenan is a food stabilizer agent which has an antiproliferative effect, while vitamin D is a prohormone acts on the nuclear receptor and has a cytotoxic against cancer. This study aimed to show the synergistic effect of using topical κ-carrageenan and oral administration of the vitamin D on the 7, 12-dimethylbenz[a] anthracene (DMBA)-induced oral cancer. Material and Methods: fifty four male albino rats were randomly divided into seven groups: Acetone-treated served as control (Group I), vitamin D (5000UI)-treated (Group II), κ-carrageenan (1%)- treated (Group III), DMBA (0.5%)-treated (Group IV), Acetone, κ-carrageenan and DMBA were administered topically on both cheeks and palate, five times weekly for 12 weeks, while the vitamin D was administered orally twice weekly for 12 weeks. Groups V, VI, and VII were animals treated with vitamin D, κ-carrageenan, and both vitamin D and κ-carrageenan for 8 weeks after induction of oral cancer. At the end of the study, blood samples were obtained by cardiac puncture for determination of TNF-α and EGFR. Results: In the groups III and IV, serum EGFR showed significant low levels compared with Group I. In the Group VII, serum EGFR showed a significantly (p=0.014) low level compared with Group IV (614.3±69.7 pg/ml versus 882.4±45.6 pg/ml, respectively). Higher percentages of high levels of TNF-α were observed in the Groups VI and VII, while a lower percentage of EGFR was observed in the Group VI. Conclusion: both κ-carrageenan and vitamin D have antiproliferative effect against DMBA-inducing oral cancer by increasing the levels of TNF-α and suppressing the signaling pathway of EGFR. Concomitant using κ-carrageenan and vitamin D reduces the antiproliferative effect of each other. KeywordsOral cancer; 7, 12-dimethylbenz[a] anthracene; Vitamin D; κ-carrageenan; Epidermal growth factor receptor; Tumor necrosis factor-α.

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Proinflammatory cytokines as serum biomarker in oral carcinoma—A prospective multi‐biomarker approach

Abstract: In conclusion, IL-6, IL-8, and sIL-2R are strongly associated with OSCC oncogenesis and IL-6 and sIL-2R seem to be promising and potent biomarkers for evaluating patients' prognosis.

Cited by 26 publications

References 26 publications

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Concomitant using of topical carrageenan-kappa and oral vitamin D against 7, 12-dimethylbenz[a]anthracene induced-oral cancer in rats: A synergism or an antagonism effects

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