Proinflammatory Cytokines and Metalloproteases Are Expressed in the Subacromial Bursa in Patients With Rotator Cuff Disease

Voloshin, Ilya; Gelinas, Jill; Maloney, Michael D.; O’Keefe, Regis J.; Bigliani, Louis U.; Blaine, Theodore A.

doi:10.1016/j.arthro.2005.05.017

Cited by 188 publications

(195 citation statements)

References 26 publications

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“…8,9 Our data showed that HA significantly and dose-dependently inhibited the expression of mRNA for IL-1b, IL-6, and TNF-a in …”

Section: Discussionmentioning

confidence: 90%

“…7 Proinflammatory cytokines and enzymes (IL-1, TNF-a, IL-6, and COX-2) produced by SSF play a major role in shoulder pain. 8,9 Our previous studies demonstrated that the level of IL-1b mRNA expression in SSF correlates well with the degree of in rotator cuff disease. 10 Hyaluronic acid (HA), a large glycosaminoglycan composed of repeating disaccharides of D-glucuronic acid and N-acetyl-glucosamine, is an integral component of articular cartilage matrix and plays an important role in joint lubrication.…”

mentioning

confidence: 99%

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Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E₂ production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

Mitsui

Gotoh

Nakama

et al. 2008

Journal Orthopaedic Research

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A growing body of evidence supports use of intraarticular hyaluronic acid (HA) injection in patients with rotator cuff disease. However, the mechanism of its anti-inflammatory action has not been clarified. We examined the effects of HA on the expression of mRNAs for proinflammatory cytokines (IL-1b, IL-6, and TNF-a and COX-2/PGE 2 production in IL-1-stimulated subacromial-synovium fibroblasts (SSF) derived from patients with rotator cuff disease. Various concentrations of HA were added to monolayer SSF cultures in the presence of IL-1b. Gene expression levels were analyzed by quantitative real-time reverse transcription-polymerase chain reaction. Intracellular production of COX-2 was identified by Western blotting. PGE 2 concentrations in the culture media were measured by ELISA. CD44 blocking with OS/37 was performed to investigate the mechanism of action of HA. Immunofluorescence cytochemistry confirmed binding of HA and the presence of CD44 on SSF. Exogenous HA significantly and dose-dependently decreased expression of proinflammatory cytokine mRNAs and COX-2/PGE 2 production in IL-1-stimulated SSF. Pretreatment with OS/37 reversed the inhibitory effects of HA. These results provide a basis for explaining why HA is effective for the treatment of rotator cuff disease. ß

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“…8,9 Our data showed that HA significantly and dose-dependently inhibited the expression of mRNA for IL-1b, IL-6, and TNF-a in …”

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E₂ production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

Mitsui

Gotoh

Nakama

et al. 2008

Journal Orthopaedic Research

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“…Jones and Flannery [16] also investigated the effects of various cytokines on lubricin expression and suggested transforming growth factor (TGF)-b increased lubricin synthesis, secretion, and cartilage boundary association. Among the cytokines found in animal models [17,18] and human subjects with ruptured rotator cuffs [21,25,33] is TGF-b [17,25]. Moreover, of importance is a recent finding [34] that contraction of myofibroblasts (ie, a-SMA expressing fibroblast) in the torn rotator cuff [22] activates latent TGF-b1 from extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

“…The antilubricin monoclonal antibody was made in the mouse against human superficial zone protein [27]. This antibody reacts with various mammalian lubricin molecules, including human [27,35], goat [8], dog [27,29], bovine [33,35], guinea pig [27], and rabbit [27]. The S6.79 antibody recognizes the amino terminus of lubricin.…”

Section: Methodsmentioning

confidence: 99%

Distribution of Lubricin in the Ruptured Human Rotator Cuff and Biceps Tendon: A Pilot Study

Funakoshi

Martin

Schmid

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…Several studies have quantified the presence of inflammatory cytokines and matrix metalloproteinases (MMPs) in the synovial fluid and subacromial bursa in the presence of rotator cuff pathology. [18][19][20] These studies have shown higher levels of interleukin (IL) 1, IL-6, tumor necrosis factor a, MMP-2, and MMP-13 in patients with rotator cuff pathology, as well as statistically significantly higher levels of inflammatory cytokines and MMPs in the synovium of full-thickness rotator cuff tears versus PTRCTs. [18][19][20] In addition, higher levels of IL-6, IL-1, and tumor necrosis factor a have been shown in the subacromial bursa in patients with full-thickness rotator cuff tears.…”

Section: Discussionmentioning

confidence: 99%

A Novel Arthroscopic Inside-Out Repair Technique for PASTA Lesions

Caldwell

Elfar

2014

Arthroscopy Techniques

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There is no current consensus in the literature on the optimal technique for surgical treatment of partial articular-sided supraspinatus tendon avulsion (PASTA) lesions, although most techniques described to date require takedown of the partially torn tendon or passage of an anchor through the already damaged tendon. We describe a novel inside-out repair technique for partial articular surface supraspinatus tears that does not require further disruption of the partially torn tendon by passage of an anchor.P artial-thickness rotator cuff tears (PTRCTs) have long been recognized as distinct from full-thickness rotator cuff tears. They have been noted in as many as 26% of asymptomatic patients aged 40 to 60 years 1 but can present with a wide spectrum of symptoms including a higher level of reported pain than fullthickness tears. 2 They have also been noted to occur in the younger population, particularly overhead throwing athletes. 3 Only recently, however, has the literature recognized articular-sided PTRCTs as distinct from bursal-sided PTRCTs in both mechanism and potential treatment modalities. 4 Articular surface PTRCTs are reported 2 to 3 times more commonly than bursal-only PTRCTs in the literature. 5 More partial-thickness tears in older patients are articular-sided supraspinatus tears than bursal sided, and the most commonly reported tear in younger overhead throwing athletes is on the articular side at the supraspinatus-infraspinatus junction. 4 It has been noted that there is a relative hypovascularity of the articular surface of the supraspinatus tendon compared with the bursal surface, which may contribute to the higher incidence of degenerative tearing of the articular surface at the insertion of the supraspinatus. 6 The articular and bursal sides of the supraspinatus differ in their histology as well: The bursal side of the cuff contains mainly tendinous bundles, giving it a greater tensile strength, whereas the articular side is a more complex mixture of ligament, capsule, and tendon. 7 Although the initial treatment for most articular-sided PTRCTs is nonoperative and symptomatically oriented, the natural history of these lesions remains unclear. Cadaveric studies have shown an increase in strain on the remaining intact supraspinatus tendon during abduction when a 33% thickness partial articular-sided supraspinatus avulsion (PASTA) lesion is created, 8 and a serial arthrography study found that 27% of articular-sided tears progressed to full-thickness tears over a 1-year period whereas only 10% appeared to heal completely. 9 This finding suggests that even when nonoperative treatment is successful in resolving symptoms, it is unlikely that this represents healing of the tear. Failure of conservative management is considered an indication for surgical intervention.There is no consensus in the literature regarding the ideal technique for treatment of PASTA lesions, although many techniques have been described, including simple debridement, tear completion and complete repair, and a variety ...

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Proinflammatory Cytokines and Metalloproteases Are Expressed in the Subacromial Bursa in Patients With Rotator Cuff Disease

Cited by 188 publications

References 26 publications

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E₂ production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E₂ production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

Distribution of Lubricin in the Ruptured Human Rotator Cuff and Biceps Tendon: A Pilot Study

A Novel Arthroscopic Inside-Out Repair Technique for PASTA Lesions

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Proinflammatory Cytokines and Metalloproteases Are Expressed in the Subacromial Bursa in Patients With Rotator Cuff Disease

Cited by 188 publications

References 26 publications

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E2 production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E2 production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

Distribution of Lubricin in the Ruptured Human Rotator Cuff and Biceps Tendon: A Pilot Study

A Novel Arthroscopic Inside-Out Repair Technique for PASTA Lesions

Contact Info

Product

Resources

About

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E₂ production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase‐2/prostaglandin E₂ production via CD44 in interleukin‐1‐stimulated subacromial synovial fibroblasts from patients with rotator cuff disease