Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment

Abstract

The combination of the periodontal therapy and antilipemic treatment may provide beneficial effects on the metabolic and inflammatory control of hyperlipidemia.

Is there a relationship between hyperlipidemia and periodontitis?

“…These findings may also favor an affirmative relationship between serum lipids and periodontal tissue response or vice-versa and are in line with aforementioned studies. 10,22,26,27,29,31,56 In the present study, age, number of missing teeth and BMI were significantly higher in the hyperlipidemic group compared to the normolipidemic group. The finding of revealed number of missing teeth was consistent with the assumption stating association between periodontal disease progression and serum lipid levels.…”

“…The comparisons of periodontal clinical parameters between normolipidemic individuals and hyperlipidemic patients showed that PD, BOP, CAL and CPITN in the hyperlipidemic group were significantly higher compared with normolipidemic group. This result demonstrates that patients with hyperlipidemia may have a pronounced tissue response and show a high rate periodontal disease susceptibility than those who are normolipidemic, 10,22,26,27,29,31,56 although PI and GI of the groups were similar. Hence, the similarity in the oral hygiene regimens of the groups by means of brushing/interdental cleaning is of importance in creation a homogeneous population necessary for true assessment of any relationship between periodontal disease and hyperlipidemia.…”

“…Findings of this study may support the evidences that suggest a strong association between hyperlipidemia and periodontal disease. 22,[27][28][29][30][31]35,36,56,58 There are also studies demonstrating that periodontal disease is highly associated with coronary heart disease, 40 even with acute myocardial infarction. 70 Keeping in mind that the role of hyperlipidemia together with the inflammation in the formation of atherosclerosis cannot be hypothetically rejected.…”

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

“…Overall, LPO products lead to increased immune response, fibrosis or inflammation, inactivation of thiol-containing enzymes, gene transcription, or triggered apoptosis due to higher molecular activity, and are associated with CVD (11). The role of LPO in CVD and periodontitis has been confirmed by studies examining the association between periodontitis and impaired lipid metabolism (5,40,41). Increased LPO in serum and periodontal tissue was observed in case of experimental periodontitis (42).…”

Impact of chronic stress on periodontal health

“…This type of diet can result in plaque accumulation [35]. Overconsumption of high-fat foods induced by stress can lead to increased cortisol production and thus immunosuppression [35,37]. Any changes to diet can cause stress and can be a risk factor for periodontal disease [25,35].…”