Proinflammatory and antiinflammatory cytokines after cardiac operation: different cellular sources at different times

Franke, Axel; Lante, Wolfgang; Fackeldey, V.; Becker, Horst Peter; Thode, Christian; Kuhlmann, W. D.; Markewitz, Andreas

doi:10.1016/s0003-4975(02)03658-5

Cited by 57 publications

(59 citation statements)

References 35 publications

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“…Fragmentation of major constituents of the lung skeleton may also occur. Increased levels of ROS may also increase Interleukin (IL)-1 and IL -8 production, 18 and also other cytokines, 19,20 in several cell systems. Other changes include changes in protein structure, leading to altered antigenicity and thus immune responses, contraction of smooth muscle, impairment of β-adrenoceptor function, stimulation of airway secretion, pulmonary vascular smooth muscle relaxation or contraction, and activation of mast cells.…”

Section: Discussionmentioning

confidence: 99%

Effect of N - Acetylcysteine on Pulmonary Function in Patients Undergoing Off Pump Coronary Artery Bypass Grafting

Jalakandan¹,

Bhaskaran²

2015

jemds

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OBJECTIVE:Postoperative lung injury is one of the most frequent complications of cardiac surgery. Increasingly used Off Pump Coronary Artery Bypass Grafting (OPCABG) has significantly reduced the oxidative stress and the inflammatory response associated with the use of cardiopulmonary bypass (CPB). However, OPCABG is also associated with significant oxidative stress and its related complications. The present study is a prospective, randomized, double blind investigating the effects of N-acetylcysteine (NAC), a potent anti-oxidant on pulmonary functions in patients undergoing OPCABG. METHODS: Fifty patients undergoing elective OPCABG were randomized into two groups. Group A (n=25), the control group received 200ml of Normal saline immediately following induction whereas Group B (n=25), the study group received 150mg/kg of NAC in 200ml of Normal saline at the same time. Pulmonary Capillary Wedge Pressure (PCWP), Pulmonary Artery Pressure (PAP), Dynamic lung compliance (C Dyn), Static lung compliance (C Stat), Alveolar -arterial oxygen gradient (A-a Do2) were measured immediately following induction, after admission into ICU, and then 4 th hourly till extubation. Malondialdehyde (MDA) and Glutathione (GSH) levels were assayed once immediately following induction and again immediately after shifting to ICU. RESULTS: Demographic profile, pre-incision clinical and biochemical values were comparable in both the groups. PCWP, PAP-Diastole were lower and C Dyn and C Stat were significantly higher in study group when compared to control group. No difference in PAP-Systole was found. Both the groups had increased A-a Do2, but the increase was significantly lower in the study group. At the end of surgery, MDA levels were significantly raised in control group (p<0.001) whereas its levels were maintained in study group (p<0.569). GSH levels were significantly decreased in control group (p<0.001) whereas its levels were significantly increased in study group (p<0.001). CONCLUSION: OPCABG was associated with significant oxidative response but the administration of NAC attenuates this stress response by replenishing the GSH stores. NAC improves pulmonary function in terms of increased compliance and increased systemic oxygenation.

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Section: Discussionmentioning

confidence: 99%

Effect of N - Acetylcysteine on Pulmonary Function in Patients Undergoing Off Pump Coronary Artery Bypass Grafting

Jalakandan¹,

Bhaskaran²

2015

jemds

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“…[6][7][8][9][10]24 Proinflammatory mediators such as cytokines are thought to play an important role in the systemic inflammatory response syndrome. …”

Section: Discussionmentioning

confidence: 99%

“…11 Serum concentrations of proinflammatory cytokines are increased in response to the impact of cardiac surgery under CPB. [6][7][8][9] but it is unknown whether the serum cytokine levels and cytokine expression in PF reflect each other. Because peritoneal dialysis is helpful in modulating the postoperative body fluid balance, prophylactic use is recommended for selected patients experiencing LOS.…”

Section: Circulation Journal Vol71 June 2007mentioning

confidence: 99%

Significance of Peritoneal Fluid Drainage in Management After Repair of Complex Heart Defects in Infancy Cytokine Dynamics In Vivo

Kurobe

Kitaichi

Shimahara

et al. 2007

Circ J

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“…Cardiac surgery with CPB initiates a profound systemic inflammatory response, characterized by increased level of inflammatory mediators and oxidative stress mediators which have been shown to be correlated with the incidence of organ dysfunction and adverse clinical outcome [1]. The proinflammatory mediators such as tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-8 are associated with anti-inflammatory mediators such as IL-10 and TGF-β [2]. However, the net effect of these circulating inflammatory mediators seems to be distorted as inhibition of innate immune cells, the molecular and cellular mechanisms responsible for suppression of the immune system after cardiac surgery with CPB [3].…”

Section: Introductionmentioning

confidence: 99%

Remifentanil Attenuates Systemic Inflammatory Response in Patients undergoing Cardiac Surgery with Cardiopulmonary Bypass

Lee¹,

Tin²,

Kim³

et al. 2017

Arch Med.

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Proinflammatory and antiinflammatory cytokines after cardiac operation: different cellular sources at different times

Cited by 57 publications

References 35 publications

Effect of N - Acetylcysteine on Pulmonary Function in Patients Undergoing Off Pump Coronary Artery Bypass Grafting

Effect of N - Acetylcysteine on Pulmonary Function in Patients Undergoing Off Pump Coronary Artery Bypass Grafting

Significance of Peritoneal Fluid Drainage in Management After Repair of Complex Heart Defects in Infancy Cytokine Dynamics In Vivo

Remifentanil Attenuates Systemic Inflammatory Response in Patients undergoing Cardiac Surgery with Cardiopulmonary Bypass

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