Proinflammatory and anti-inflammatory cytokine changes related to menopause

Măluţan, Andrei Mihai; Mihu, Dan; Costin, Nicolae; Carmen, Mihu

doi:10.5114/pm.2014.43818

Cited by 69 publications

(65 citation statements)

References 26 publications

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“…Significant differences were found in vascular parameters between cases and controls like loops diameter, vessels tortuosity in labial mucosa and periodontal mucosa density was changed in view of predisposed to inflammation [18]. The ingrained studies have stated that a low systemic inflammatory status was associated with the onset of menopause and slowly the inflammatory condition increases with the downturn of hormones associated with menopause and increased serum levels of proinflammatory cytokines IL-1, IL-6, or tumor necrosis factor α in postmenopause women [19][20][21][22]. Osteopenia was more common in premenopausal women than postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Analysis of Three Biological Fluids and its Response to Non-Surgical Periodontal Therapy in Pre and Postmenopausal Women with Periodontitis

Prasanna

Sumadhura

2019

J Menopausal Med

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Objectives: Periodontitis is a common chronic inflammatory disease characterized by the destruction of the supporting structures of the teeth. The stages of menopause also worsen inflammatory condition. Biomarkers from biological fluids can be used as a diagnostic indicator to correlate these two conditions of present and future disease activity. The aim of the present study was to evaluate the neopterin levels in three biological fluids obtained from pre-and postmenopausal women with periodontitis following non-surgical periodontal therapy (NSPT, that is, scaling). Methods: This was a cross-sectional interventional study. Thirty women, aged 40-60 years, with periodontitis were selected according to their menstrual history. They were divided into the pre-and postmenopausal groups, with each group including 15 participants. The neopterin levels were measured in both groups at baseline and 3 months after NSPT. Intergroup comparison and percentage decrement analysis were performed using the independent sample t test, and intragroup comparison was performed using the paired t test. Results: There were statistically significant reductions in the mean values of saliva, urine, and plasma from baseline to 3 months after NSPT in the groups. Intergroup comparison showed no significant values in the postmenopausal group, and a significant reduction was seen in the mean values was seen in the mean values. Conclusions: : Neopterin levels decreased at 3 months after NSPT in both the groups, suggesting that NSPT can be a gold standard therapy and that the neopterin level could be a indicator to identify periodontal destruction.

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Section: Discussionmentioning

confidence: 99%

Biochemical Analysis of Three Biological Fluids and its Response to Non-Surgical Periodontal Therapy in Pre and Postmenopausal Women with Periodontitis

Prasanna

Sumadhura

2019

J Menopausal Med

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“…Their levels correlate with a higher BMI and this significant increase in IL-8 level persist for a long period after estrogen deficiency. [59,11,60] In contradiction, Dorneles et al [61] demonstrated that high intensity interval exercise (HIIE) decreased IL-8 in lean and obese individuals. Also, Thorbjorn et al [62] founded that exercise increased IL-8 expression in skeletal muscle but small release of IL-8 from muscle not elevate plasma level of IL-8.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

hamed¹,

Ahmed²,

Bedair³

et al. 2018

Zagazig University Medical Journal

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Background: Cardiovascular disease (CVD) is one of the leading causes of death worldwide and is more prevalent in post-menopausal women. Monocyte chemo-attractant protein-1(MCP-1) is a chemokine that attracts monocytes/macrophages to sites of inflammation and play a role in development of atherosclerosis. Objective: This study aimed to explore the effects of ovariectomy (Ovx) as a model of menopause on the serum level of MCP-1 in high fat diet induced atherogenesis and clarify the modulatory effects of moderate exercises on the serum level of MCP-1 in this model. Animals and methods: 96 female albino rats divided equally into 4 groups, each is subdivided equally into 2subgroups subgroup (Ia): non ovx ,sedentary, fed standard diet for 10 weeks, subgroup (Ib): non ovx ,sedentary, fed high fat diet for 10 weeks. Subgroup (IIa) ovx sedentary, fed standard diet for 10 weeks subgroup (IIb): ovx, sedentary fed high fat diet for 10 weeks. Subgroup (IIIa): non ovx ,exercised and fed standard diet for 10 weeks. subgroup (IIIb) non ovx ,exercised and fed high fat diet for 10 weeks. Subgroup (IVa): ovx ,exercised and fed standard diet for 10 weeks. subgroup (IVb) ovx ,exercised and fed high fat diet for 10 weeks. Results: in ovx obese sedentary rats, there was a significant (p <0.001) increase in MCP-1,Lipid profile, Atherogenic indices, Platelets activation percentage, Total leucocytic counts, Differential monocyte counts, and Interleukin 8 and aortic thickness versus lean subgroup. Swimming exercise showed significant (p <0.001) reductions in the above parameters, associated with significant increase in the serum HDL level in ovx obese exercised subgroup versus ovx obese sedentary subgroup. Conclusions: MCP-1 level increased in obesity and menopause leading to development of atherosclerosis and these changes could be reversed by adaptive moderate exercises.

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“…Given that our study population was primarily middle-aged, it is also possible that hormonal changes related to oral contraceptive use and menopause in women might influence immune responses. (45, 46)…”

Section: Discussionmentioning

confidence: 99%

Association of serum cytokines with oral HPV clearance

et al. 2016

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Background Initial studies suggest higher serum levels of some pro-inflammatory cytokines may be associated with decreased cervical human papillomavirus (HPV) clearance. However, the relationship of cytokines with oral HPV clearance has not been explored. Methods From 2010 to 2014, oral rinse and serum samples were collected semi-annually from 1,601 adults. Oral rinse samples were tested for HPV DNA using PCR. Based on oral HPV results, 931 serum samples were selected for cytokine evaluation to include a roughly equal number of prevalent (n=307), incident (n=313), and no oral HPV infections (n=311). Electrochemiluminescence multiplex assays were used to determine the concentrations of IL-6, IL-8, TNF-α, IFN-γ, IL-1β, IL-2, IL-4, IL-10, IL-12 and IL-13. The relationship between serum cytokine concentrations (categorized into quartiles) and oral HPV clearance was evaluated with Wei-Lin-Weissfeld regression models, adjusting for HPV infection type (prevalent vs. incident), age, HIV status, and CD4 T cell count. Results Higher TNF-α concentration was associated with decreased clearance in men (highest vs. lowest quartile, adjusted hazard ratio [aHR]=0.52, 95% CI=0.34-0.79) and women (aHR=0.76, 95% confidence interval [CI]=0.55-1.04), with stronger associations in men than women (p-interaction=0.049). Higher IL-2 concentration was associated with reduced clearance in men (aHR=0.69, 95% CI=0.50-0.95), but not women (p-interaction=0.058). Results were similar within CD4 T cell strata (CD4 ≥500 or CD4<500 cells/μl) among HIV-infected participants. No other cytokines were associated with clearance. Conclusion High serum TNF-α is associated with reduced clearance of oral HPV infection.

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Proinflammatory and anti-inflammatory cytokine changes related to menopause

Cited by 69 publications

References 26 publications

Biochemical Analysis of Three Biological Fluids and its Response to Non-Surgical Periodontal Therapy in Pre and Postmenopausal Women with Periodontitis

Biochemical Analysis of Three Biological Fluids and its Response to Non-Surgical Periodontal Therapy in Pre and Postmenopausal Women with Periodontitis

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

Association of serum cytokines with oral HPV clearance

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