Prohormone Convertases☆

Engineered, Scalable Production of Optically Pure l-Phenylalanines Using Phenylalanine Ammonia-Lyase from Arabidopsis thaliana

“…Further, we envisaged the production of enantiopure l -Phe analogues of high synthetic value for the pharmaceutical industry (Figure ). Accordingly, l -2-methylphenylalanine 2c is used as chiral synthon within the synthesis of endomorphin-2 analogues of improved affinities for μ-opioid receptors, while l -3-methylphenylalanine 2g can be integrated within cathepsin B inhibitors , involved in the pathogenesis of several diseases, most notably Alzheimer’s disease (AD) and cancer . Bromo-substituted phenylalanines 2a and 2i play key roles within the synthesis of NTS2 selective neurotensin ligands used for reducing tonic pain sensitivity or within the production of several biarylalanines and biaryl-bridged macrocyclic peptides .…”

Repurposing proteases: An in-silico analysis of the binding potential of extracellular fungal proteases with selected viral proteins

“…From the orthology analysis, it was seen that some of the enzymes- such as tripeptidyl-peptidase 1, cerevisin and cathepsin, are lysosomal components where their natural function is protein degradation ( He et al, 2015 ; Sohar et al, 2013 ), while others, like carboxypeptidase D, kexin and leucyl aminopeptidases, are involved in the pre-processing of proteins, especially hormones ( Cawley et al, 2014 ; Fuller, 2013 ). Interestingly, one of the proteins matched to deuterolysin, which has long been used in the food industry, and is known usually to be thermostable ( Maeda et al, 2016 ).…”