Prohibitin Inhibits Tumor Necrosis Factor alpha–induced Nuclear Factor-kappa B Nuclear Translocation via the Novel Mechanism of Decreasing Importin α3 Expression

Theiss, Arianne L.; Jenkins, Aaron; Okoro, Ngozi I.; Klapproth, Jan–Michael A.; Merlin, Didier; Sitaraman, Shanthi V.

doi:10.1091/mbc.e09-05-0361

Cited by 68 publications

(88 citation statements)

References 41 publications

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“…Restoration of colonic epithelial PHB expression using genetic manipulation (villin-PHB transgenic mice) or therapeutic delivery to the colon via nanoparticle or adenovirus protected mice from experimental colitis [43,44]. Our recent data suggest that epithelial PHB sustains anti-oxidant expression [44] and has anti-inflammatory properties such as reducing TNFa-stimulated NF-kB activation [42]. This is in agreement with emerging data that suggest a role of PHB in combating oxidative stress in multiple cells types [39,40,45,46].…”

Section: Introductionsupporting

confidence: 88%

“…We have previously shown that expression of PHB protein is reduced in mucosa during active inflammatory bowel disease and in Caco2-BBE cells treated with TNFa or exogenous oxidants [37,42]. It has been demonstrated that TNFa and IFNc induce autophagy in intestinal epithelium [31,55] and that autophagy can attenuate inflammatory responses, thereby maintaining intestinal homeostasis [56].…”

Section: Discussionmentioning

confidence: 99%

“…We have shown previously that exogenous PHB expression in Caco2-BBE cells induced the expression of glutathione-S-transferase p, an antioxidant enzyme that catalyzes the conjugation of electrophiles to GSH [37], and modulates the activity of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcriptional regulator of antioxidant response [42]. PHB overexpression may reduce basal autophagy through an increased antioxidant response on ROS production during normal physiological respiration.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous studies showed that TNFa reduces expression of PHB in intestinal epithelial cells in vivo and in vitro [42]. Proinflammatory cytokines such as TNFa and IFNc have been shown to induce autophagy in human intestinal epithelial cell lines [31,47].…”

Section: Phb Protein Expression Inversely Correlates With Cytokine-inmentioning

confidence: 98%

“…Pro-inflammatory cytokines such as TNFa and oxidative stress induced by exogenous H 2 O 2 decrease expression of intestinal epithelial PHB in vivo and in vitro [37,42]. Restoration of colonic epithelial PHB expression using genetic manipulation (villin-PHB transgenic mice) or therapeutic delivery to the colon via nanoparticle or adenovirus protected mice from experimental colitis [43,44].…”

Section: Introductionmentioning

confidence: 99%

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320 Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells

Kathiria¹,

Butcher²,

Feagins³

et al. 2012

Gastroenterology

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Section: Introductionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Phb Protein Expression Inversely Correlates With Cytokine-inmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

320 Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells

Kathiria¹,

Butcher²,

Feagins³

et al. 2012

Gastroenterology

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Tissue proteomics of splenic marginal zone lymphoma

et al. 2015

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Splenic marginal zone lymphoma (SMZL) is a rare chronic B lymphoproliferative disease, whose molecular pathogenesis has still not been well established. For the first time, a proteomic approach was undertaken to analyse the protein profiles of SMZL tissue. 1D and 2D Western blot, immunohistochemical analysis, and functional data mining were also performed in order to validate results, investigate protein species specific regulation, classify proteins, and explore their potential relationships. We demonstrated that SMZL is characterized by modulation of protein species related to energetic metabolism and apoptosis pathways. We also reported specific protein species (such as biliverdin reductase A, manganese superoxide dismutase, beta-2 microglobulin, growth factor receptor-bound protein 2, acidic leucine-rich nuclear phosphoprotein 32 family member A, and Set nuclear oncogene) directly involved in NF-kB and BCR pathways, as well as in chromatin remodelling and cytoskeleton. Our findings shed new light on SMZL pathogenesis and provide a basis for the future development of novel biomarkers. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the dataset identifier PXD001124.

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Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis

Theiss¹,

Laroui²,

Obertone³

et al. 2011

Inflammatory Bowel Diseases

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Introduction-Intestinal epithelial expression of anti-oxidants and NF-κB contribute to mucosal barrier integrity and epithelial homoestasis, two key events in the pathogenesis of inflammatory bowel disease. Genetic restoration of intestinal epithelial prohibitin 1 (PHB) levels during experimental colitis reduces the severity of disease through sustained epithelial anti-oxidant expression and reduced NF-κB activation. To determine the therapeutic potential of restoring epithelial PHB during experimental colitis in mice, we assessed two methods of PHB colonic mucosal delivery: adenovirus-directed administration by enema and poly (lactic acid) nanoparticle (NPs) delivery by gavage.

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Prohibitin Inhibits Tumor Necrosis Factor alpha–induced Nuclear Factor-kappa B Nuclear Translocation via the Novel Mechanism of Decreasing Importin α3 Expression

Abstract: Expression of prohibitin 1 (PHB), a multifunctional protein in the cell, is decreased during inflammatory bowel disease (IBD).

Cited by 68 publications

References 41 publications

320 Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells

320 Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells

Tissue proteomics of splenic marginal zone lymphoma

Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis

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