Prohibitin 2: A key regulator of cell function

Prohibitions in the meta-inflammatory response: a review

“…The prohibitin family comprises several proteins, of which Prohibitin 1 (PHB1) and Prohibitin 2 (PHB2) are the best studied. PHB1 and PHB2 have a molecular weight of 31 kDa and 37 kDa ( Zhang et al, 2024 ) or 32 and 34 kDa ( Signorile et al, 2019 ).…”

“…The PHB1 gene has been assigned to chromosomal locus 17q12-q21, near genes responsible for the deposition of adipose tissue and genes that regulate eating behavior and sex hormone levels ( Mishra et al, 2010 ). The PHB2 gene is located on chromosome 12p13 ( Zhang et al, 2024 ) next to the AdipoR2 gene (12p13.33), which codes for the adiponectin receptor (adipose tissue hormone) and is associated with obesity and the hypothalamic satiety response ( Mora-García et al, 2017 ).…”

“…The LIR domain of PHB2 binds directly to LC3 and regulates mitophagy ( Wei et al, 2017 ; Yan et al, 2020 ). In addition, PHB2 can bind to the autophagy receptor optineurin (OPTN) via the LIR domain, which is translocated to the mitochondria under the influence of PINK1-mediated phosphorylation of PRKN, leading to the recruitment of LC3 and other autophagic factors (ULK1, DFCP1, WIPI1) ( Zhang et al, 2024 ). Alternatively, PHB2 may interact with the UBAN domain of OPTN via ubiquintin chains to regulate autophagy ( Zhang et al, 2024 ).…”

“…In addition, PHB2 can bind to the autophagy receptor optineurin (OPTN) via the LIR domain, which is translocated to the mitochondria under the influence of PINK1-mediated phosphorylation of PRKN, leading to the recruitment of LC3 and other autophagic factors (ULK1, DFCP1, WIPI1) ( Zhang et al, 2024 ). Alternatively, PHB2 may interact with the UBAN domain of OPTN via ubiquintin chains to regulate autophagy ( Zhang et al, 2024 ). In this case, PHB2 may play a dual role in mitophagy: as a receptor and as a protein to recruit autophagosomes ( Figure 1 ).…”

“…In addition, activated PRKN induces rupture of the OMM via the RING2 domain and binds directly to PHB2, promotes ubiquintylation of the K33/K142 site of PHB2 and induces the interaction of PHB2 with LC3 ( Zhang et al, 2024 ) ( Figure 1 ).…”