Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle

Alders, David J. C.; Groeneveld, A. B. Johan; Binsl, Thomas W.; Beek, Hans van

doi:10.1152/ajpheart.00657.2014

Cited by 5 publications

(2 citation statements)

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“…NMR spectroscopy makes it possible to measure metabolites and metabolic fluxes in tissue non-invasively, although with limited sensitivity [90,91]. Providing the body with nutrients that have been labelled with stable isotopes makes it possible to follow metabolism by taking samples from blood, gut content [88], tissue samples [92][93][94][95] or measuring metabolic fluxes non-invasively by positron emission tomography or NMR spectroscopy [96]. Almost completely carbon-13 enriched plants are for instance available to serve as a source of nutrition labelled with a stable (non-radioactive) isotope, meaning it can be determined how the carbon atoms travel in the metabolic networks and even making quantitation of fluxes possible.…”

Section: Possible Contributions To the Quantitativementioning

confidence: 99%

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance

2016

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One contribution of 12 to a theme issue 'The Human Physiome: a necessary key to the creative destruction of medicine'. Ageing and lifespan are strongly affected by metabolism. The maximal possible uptake of oxygen is not only a good predictor of performance in endurance sports, but also of life expectancy. Figuratively speaking, healthy ageing is a competitive sport. Although the root cause of ageing is damage to macromolecules, it is the balance with repair processes that is decisive. Reduced or intermittent nutrition, hormones and intracellular signalling pathways that regulate metabolism have strong effects on ageing. Homeostatic regulatory processes tend to keep the environment of the cells within relatively narrow bounds. On the other hand, the body is constantly adapting to physical activity and food consumption. Spontaneous fluctuations in heart rate and other processes indicate youth and health. A (homeo)dynamic aspect of homeostasis deteriorates with age. We are now in a position to develop computational models of human metabolism and the dynamics of heart rhythm and oxygen transport that will advance our understanding of ageing. Computational modelling of the connections between dietary restriction, metabolism and protein turnover may increase insight into homeostasis of the proteins in our body. In this way, the computational reconstruction of human physiological processes, the Physiome, can help prevent frailty and age-related disease.

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Section: Possible Contributions To the Quantitativementioning

confidence: 99%

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance

2016

Self Cite

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“…In dogs, the importance of hematocrit distal to a coronary artery with a decreased blood flow revealed that both hematocrit and oxygen delivery to the myocardium in the stenotic distal artery was lower than control values and was accompanied by an increase in the fraction of plasma volume (Eliasen & Amtorp, 1985b). Moreover, graded coronary stenosis in the porcine left ventricle caused a progressively heterogeneous mismatch of regional O 2 delivery/consumption (Alders et al, 2015). These findings indicate that during ischemia the myocardium suffers the consequences not only a diminished blood supply, but also is perfused with blood containing a smaller number of RBCs, and therefore has a lowered oxygen delivery capacity.…”

Section: Capillary Regulation Of Blood Flow and Oxygen Extractionmentioning

confidence: 99%

The coronary capillary bed and its role in blood flow and oxygen delivery: A review

Tomanek

2022

The Anatomical Record

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The assumption that the coronary capillary blood flow is exclusively regulated by precapillary vessels is not supported by recent data. Rather, the complex coronary capillary bed has unique structural and geometric characteristics that invalidate many assumptions regarding red blood cell (RBC) transport, for example, data based on a single capillary or that increases in flow are the result of capillary recruitment. It is now recognized that all coronary capillaries are open and that their variations in flow are due to structural differences, local O2 demand and delivery, and variations in hematocrit. Recent data reveal that local mechanisms within the capillary bed regulate flow via signaling mechanisms involving RBC signaling and endothelial‐associated pericytes that contract and relax in response to humoral and neural signaling. The discovery that pericytes respond to vasoactive signals (e.g., nitric oxide, phenylephrine, and adenosine) underscores the role of these cells in regulating capillary diameter and consequently RBC flux and oxygen delivery. RBCs also affect blood flow by sensing PnormalO2 and releasing nitric oxide to facilitate relaxation of pericytes and a consequential capillary dilation. New data indicate that these signaling mechanisms allow control of blood flow in specific coronary capillaries according to their oxygen requirements. In conclusion, mechanisms in the coronary capillary bed facilitate RBC density and transit time, hematocrit, blood flow and O2 delivery, factors that decrease capillary heterogeneity. These findings have important clinical implications for myocardial ischemia and infarction, as well as other vascular diseases.

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Effect of Oxygen Therapy on Cardiovascular Outcomes in Relation to Baseline Oxygen Saturation

James

Erlinge

Herlitz

et al. 2020

JACC: Cardiovascular Interventions

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Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle

Abstract: Alders DJ, Groeneveld AB, Binsl TW, van Beek JH. Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle.

Cited by 5 publications

References 40 publications

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance

The coronary capillary bed and its role in blood flow and oxygen delivery: A review

Effect of Oxygen Therapy on Cardiovascular Outcomes in Relation to Baseline Oxygen Saturation

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