Progressive systemic sclerosis in Egyptian patients: Clinical characteristics and nail fold capillaroscopy

El‐Sayed, Amr; El-Hefny, A.; Abogabal, Mervat; Mobasher, Sameh; Abdelzaher, Amr; Alhassanein, Khaled F.; Sayed, Safaa; Haroon, Maysa M; Soliman, Hatem

doi:10.1016/j.ejr.2018.01.009

Cited by 18 publications

(3 citation statements)

References 26 publications

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“…The overall female predominance amongst adult patients (F:M=3.5:1) is comparable to other studies ( 17 , 18 ). The median adult ages differed significantly along racial subgroups being lowest in Asians (31.5 years), Blacks (35 years) and highest in White (48 years) patients.…”

Section: Discussionsupporting

confidence: 88%

“…Lung volume abnormalities were bronchodilator refractory, and the spirometry pattern was predominantly restrictive, contrary to the obstructive, bronchodilator reversible pattern that characterizes asthma. Taken together, with findings of Velcro crackles on auscultation, the spirometry findings suggest fibrotic pulmonary disease, a feature of pulmonary SSc ( 18 , 26 ). The significant association of the presence of anti-Ku, anti-PMScl-75 and anti-Ro-52 with FVC reductions supports the association of anti-Ku and anti-PMScl75 with ILD as reported by others ( 27 , 28 ).…”

Section: Discussionsupporting

confidence: 55%

See 1 more Smart Citation

Systemic Sclerosis in Zimbabwe: Autoantibody Biomarkers, Clinical, and Laboratory Correlates

Sibanda

Dube²,

Chakawa

et al. 2021

Front. Immunol.

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IntroductionSystemic sclerosis (SScl) is an autoimmune disease whose prevalence is rarely reported in Africa. Autoantibodies are the biomarkers of the condition, precede overt disease and determine disease phenotypes. SSc specific autoantibodies also vary between racial groupings. Objective: To investigate the clinical and laboratory characteristics of Zimbabwean patients who were reactive SSc specific autoantibodies.Materials and Method240 patients, 173 of them female with SSc specific autoantibodies were included. Autoantibodies were detected by indirect immunofluorescence microscopy and immunoblotting using a panel of 13 SScl (Euroimmun Ag., Germany). Demographic, clinical and laboratory parameters relevant to the monitoring of SScl were captured. These included pulmonary function tests, hematology, clinical chemistry, serology and thyroid function tests. Allergy skin prick tests (SPT) to inhalant and food allergen sources were conducted when indicated.ResultsAll the 240 patients (median age was 36 years) expressed SSc specific autoantibodies. 86% were Black, 11% White and 3% Asian and a fifth (20%) were younger than 16 years. Eleven (4.6%) fulfilled the ACR/EULAR classification of SSc. Clinically they had limited cutaneous (n=6), diffuse cutaneous (n=3) and SScl/inflammatory myopathy overlap (n=2). The most frequently detected antibodies anti-RNA polymerase III (RNAP) 55%, anti-Th/To (28%) anti-RNAP 11 (22%), anti-CENPB (18%) and anti-Scl-70/ATA (13%). Racial variations in the expression of these antibodies were apparent between Black, White and Asian patients. The majority (95%), who did not fulfil the ARA/EULAR criteria were symptomatic. Raynaud’s Phenomenon was documented in 24%. Respiratory symptoms included coughing, dyspnea and wheezing. There was a restrictive ventilatory defect with increased FEV1/FVC ratio. Pruritus, urticaria and skin depigmentation were the main cutaneous features while constipation, bloating, Gastroesophageal reflux disease (GERD) and abdominal pain dominated GI symptoms. Mean blood pressure readings while normal varied with biomarkers. Haematology and biochemistry parameters were within normal reference ranges.ConclusionThe expression of SSc specific autoantibodies is common and associated with known SSc symptoms. The types and frequency of autoantibodies varied with racial groupings. A fifth of the patients were children below the age of 16 years.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 55%

Systemic Sclerosis in Zimbabwe: Autoantibody Biomarkers, Clinical, and Laboratory Correlates

Sibanda

Dube²,

Chakawa

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…"active" or "late" scleroderma pattern (more severe patterns representing a higher prevalence of capillary obliteration), was found to be associated with the presence of SSc-ILD [46]. Of note, 4 manuscripts that had not meet the inclusion criteria to be retained and which had also performed qualitative NVC assessment, confirmed the aforementioned finding [49][50][51][52].…”

Section: Discussionsupporting

confidence: 56%