Progressive Systemic Sclerosis: Clinical Features and Pathogenesis of Cutaneous Involvement (Scleroderma)

Rodnan, Gerald P.

doi:10.1016/s0307-742x(21)00053-9

Cited by 15 publications

References 61 publications

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Double‐blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis

Williams

Fürst

Dahl

et al. 1985

Arthritis & Rheumatism

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A prospective, randomized, double-blind trial compared topical therapy with 0.85% normal saline, Dimethyl sulfoxide (DMSO) is a highly polar organic solvent which was introduced for clinical studies in 1963. Because long-term toxicity studies with DMSO showed changes in the refractive index of the lens of some species of treated animals, the Food and Drug Administration severely restricted clinical testing (1). Limited clinical testing was subsequently permitted in 1968. Ocular toxicity in humans has not been described, but efficacy remains controversial (2). While DMSO has been recommended for the treatment of many conditions, controlled data have been lacking.Patients with scleroderma (systemic sclerosis) are known to develop painful cutaneous ulcerations, particularly on the fingertips and on the dorsum of the proximal interphalangeal and metacarpophalangeal joints (3-5). These ulcers can also occur on the skin overlying the olecranon, the malleolus, and calcaneus. The ulcerations may become secondarily infected and are difficult to treat. Treatment is nonspecific and

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Double‐blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis

Williams

Fürst

Dahl

et al. 1985

Arthritis & Rheumatism

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Connective Tissue Disorders

Capell

Daymond²,

1983

Treatment in Clinical Medicine

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Denmark, and Iceland. The cases were collected during one and a half years, beginning 1 July 1997. Method-Clinical variables (including those constituting the EULAR and ILAR criteria) and laboratory findings were registered longitudinally for each patient by paediatricians experienced in paediatric rheumatology. A database was constructed specifically for this purpose. In this study clinical findings and laboratory data from the first 6 months (for certain variables also for the first 12 months) were considered. Results-322 patients qualified for classification according to the ILAR criteria. Of those 322 patients, 291 had a disease duration of >3 months and were classified according to the EULAR criteria. Thus, 31/322 (10%) children were diagnosed only according to the ILAR criteria. 15% of the patients did not fulfil ILAR criteria for any of the categories and 6% fulfilled criteria for more than one category. As an example of the eVect of diVerent classification systems in our study, 160/ 322 were classified as oligoarticular by ILAR criteria and 184/291 by EULAR criteria. Conclusion-The qualifications for the ILAR criteria are diVerent from those of the EULAR criteria, which makes simple comparison neither possible nor scientifically relevant. One possibility is to study the construct validity of the respective criteria to give us a better idea of the classification and its consequences. Juvenile spondyloarthropathies:checking criteria for diagnosis and classification at the start and after 6 months of disease

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Pathophysiology and Behavioral Treatment of Scleroderma

Freedman

Wenig

1982

Behavioral Treatment of Disease

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Progressive Systemic Sclerosis: Clinical Features and Pathogenesis of Cutaneous Involvement (Scleroderma)

Cited by 15 publications

References 61 publications

Double‐blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis

Double‐blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis

Connective Tissue Disorders

Pathophysiology and Behavioral Treatment of Scleroderma

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