Progressive supranuclear palsy: A systematic review

Rampello, Liborio; Buttà, V.; Raffaele, R; Vecchio, Ignazio; Battaglia, G.; Cormaci, G.; Alvano, Alessandro

doi:10.1016/j.nbd.2005.03.013

Cited by 38 publications

(16 citation statements)

References 97 publications

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“…Hence, assessment of stable RGs for comparative studies on PD, MSA, and PSP is highly relevant in order to strengthen the reliability of the experimental outcome. Furthermore, although PSP is clinically comparable to PD, the pathological events in PSP are similar to AD30. We investigated two disease-affected brain regions, the medial frontal gyrus of the prefrontal cortex (PFC), and the cerebellum (CB), in order to define the most stable set of RGs for comparative gene expression studies in PD, MSA, PSP, and AD brains.…”

mentioning

confidence: 99%

Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases

Rydbirk

Folke

Winge

et al. 2016

Sci Rep

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Evaluation of gene expression levels by reverse transcription quantitative real-time PCR (RT-qPCR) has for many years been the favourite approach for discovering disease-associated alterations. Normalization of results to stably expressed reference genes (RGs) is pivotal to obtain reliable results. This is especially important in relation to neurodegenerative diseases where disease-related structural changes may affect the most commonly used RGs. We analysed 15 candidate RGs in 98 brain samples from two brain regions from Alzheimer’s disease (AD), Parkinson’s disease (PD), Multiple System Atrophy, and Progressive Supranuclear Palsy patients. Using RefFinder, a web-based tool for evaluating RG stability, we identified the most stable RGs to be UBE2D2, CYC1, and RPL13 which we recommend for future RT-qPCR studies on human brain tissue from these patients. None of the investigated genes were affected by experimental variables such as RIN, PMI, or age. Findings were further validated by expression analyses of a target gene GSK3B, known to be affected by AD and PD. We obtained high variations in GSK3B levels when contrasting the results using different sets of common RG underlining the importance of a priori validation of RGs for RT-qPCR studies.

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mentioning

confidence: 99%

Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases

Rydbirk

Folke

Winge

et al. 2016

Sci Rep

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“…[1][2][3] Both are considered tauopathies. 4 Tauopathies display insoluble intraneuronal aggregates of the tau protein seen in other neurodegenerative diseases, including Alzheimer disease, and in approximately half of those with frontotemporal dementia.…”

Section: Long-term Exercise Training For An Individual With Mixed Cormentioning

confidence: 99%

Long-Term Exercise Training for an Individual With Mixed Corticobasal Degeneration and Progressive Supranuclear Palsy Features: 10-Year Case Report Follow-up

et al. 2014

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“…Clinical features of PSP have recently been reviewed [22] and include parkinsonism and axial rigidity with a tendency toward hyperextension and backward falls; eye movement abnormalities, including the supranuclear palsy (after which the disease was named), square-wave jerks, and slowing of saccades; and a pseudobulbar syndrome with dysarthria, dysphagia, and a characteristic "surprised" facial expression.…”

Section: Pspmentioning

confidence: 99%

Frontotemporal dementia

Roberson

2006

Curr Neurol Neurosci Rep

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Frontotemporal dementia (FTD) and related conditions are often considered daunting because of the numerous inter-related clinical syndromes and their apparently heterogeneous pathologic substrates. Although the labyrinthine complexity of the disease seemingly continues to grow, recent discoveries have made the maze of FTD somewhat more navigable, spurring new interest in the field. This review begins by surveying the fascinating clinical presentations of these conditions and the few currently available treatments, then turns to recent progress in understanding the pathophysiology of FTD. Among the important advances surveyed are clinicopathologic correlations that enable prediction of the pathologic substrate of certain clinical subtypes, and genetic studies that have been particularly fruitful in identifying new causes of FTD.

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Progressive supranuclear palsy: A systematic review

Cited by 38 publications

References 97 publications

Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases

Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases

Long-Term Exercise Training for an Individual With Mixed Corticobasal Degeneration and Progressive Supranuclear Palsy Features: 10-Year Case Report Follow-up

Frontotemporal dementia

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