Progressive resistance versus relaxation training for breast cancer patients during adjuvant chemotherapy: Design and rationale of a randomized controlled trial (BEATE study)

Schmidt, Martina E.; Wiskemann, Joachim; Krakowski-Roosen, Holger; Knicker, Axel; Habermann, Nina; Schneeweiß, Andreas; Ulrich, Cornelia M.; Steindorf, Karen

doi:10.1016/j.cct.2012.10.006

Cited by 34 publications

(59 citation statements)

References 63 publications

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“…For this cross‐sectional analysis, baseline data of two randomized controlled exercise trials (RCTs) in BC patients were used, i.e. the BEATE study and the BEST study (ClinicalTrials.gov NCT01106820 and NCT01468766, respectively) . These two RCTs investigated the effects of 12‐week progressive resistance training in comparison to relaxation training in BC patients undergoing adjuvant CT (BEATE study) or adjuvant radiotherapy (BEST study).…”

Section: Methodsmentioning

confidence: 99%

“…Women with histologically confirmed stage 0–III primary BC after lumpectomy or mastectomy were eligible for the studies. Further, inclusion and exclusion criteria and more details of the RCTs are presented elsewhere . In a parallel intervention study (INVEST study) with identical surveys, 26 healthy age‐matched control women participated in the same 12‐week progressive resistance training protocol to obtain comparison data.…”

Section: Methodsmentioning

confidence: 99%

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Muscle strength in breast cancer patients receiving different treatment regimes

Klassen

Schmidt

Ulrich

et al. 2016

J cachexia sarcopenia muscle

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159

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BackgroundMuscle dysfunction and sarcopenia have been associated with poor performance status, an increased mortality risk, and greater side effects in oncologic patients. However, little is known about how performance is affected by cancer therapy. We investigated muscle strength in breast cancer patients in different adjuvant treatment settings and also compared it with data from healthy individuals.MethodsBreast cancer patients (N = 255) from two randomized controlled exercise trials, staged 0–III and aged 54.4 ± 9.4 years, were categorized into four groups according to their treatment status. In a cross‐sectional design, muscle function was assessed bilaterally by isokinetic dynamometry (0°, 60°, 180°/s) as maximal voluntary isometric contraction (MVIC) and maximal isokinetic peak torque (MIPT) in shoulder rotators and knee flexors and extensors. Additionally, muscular fatigue index (FI%) and shoulder flexibility were evaluated. Healthy women (N = 26), aged 53.3 ± 9.8 years, were tested using the same method. Analysis of covariance was used to estimate the impact of different cancer treatments on skeletal muscle function with adjustment for various clinical and socio‐demographic factors.ResultsConsistently, lower muscle strength was measured in shoulder and knee strength in patients after chemotherapy. On average, patients had up to 25% lower strength in lower extremities and 12–16% in upper extremities in MVIC and MIPT during cancer treatment compared with healthy women. No substantial difference between patient groups in shoulder strength, but significantly lower shoulder flexibility in patients with radical mastectomy was measured. Chemotherapy‐treated patients had consistently higher FI%. No serious adverse events were reported.ConclusionsBreast cancer patients showed markedly impaired muscle strength and joint dysfunctions before and after anticancer treatment. The significant differences between patients and healthy individuals underline the need of exercise therapy as early as possible in order to prevent or counteract the loss of muscle function after curative surgery as well as the consequences of neo‐/adjuvant chemotherapy.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Muscle strength in breast cancer patients receiving different treatment regimes

Klassen

Schmidt

Ulrich

et al. 2016

J cachexia sarcopenia muscle

Self Cite

159

109

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“…All participants gave written informed consent. Details of the study rationales and designs have been published [17,18].…”

Section: Study Design and Populationmentioning

confidence: 99%

Cancer-related fatigue shows a stable association with diurnal cortisol dysregulation in breast cancer patients

Schmidt

Semik

Habermann

et al. 2016

Brain, Behavior, and Immunity

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“…The intervention programs and several outcome measures are based on experiences from a randomized controlled trial with breast cancer patients during chemotherapy conducted by our group (BEATE study) [38]. …”

Section: Methodsmentioning

confidence: 99%

Randomized controlled trial to evaluate the effects of progressive resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the BEST study

et al. 2013

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BackgroundCancer-related fatigue (CRF) is one of the most common and distressing side effects of cancer and its treatment. During and after radiotherapy breast cancer patients often suffer from CRF which frequently impairs quality of life (QoL). Despite the high prevalence of CRF in breast cancer patients and the severe impact on the physical and emotional well-being, effective treatment methods are scarce.Physical activity for breast cancer patients has been reported to decrease fatigue, to improve emotional well-being and to increase physical strength. The pathophysiological and molecular mechanisms of CRF and the molecular-biologic changes induced by exercise, however, are poorly understood.In the BEST trial we aim to assess the effects of resistance training on fatigue, QoL and physical fitness as well as on molecular, immunological and inflammatory changes in breast cancer patients during adjuvant radiotherapy.Methods/designThe BEST study is a prospective randomized, controlled intervention trial investigating the effects of a 12-week supervised progressive resistance training compared to a 12-week supervised muscle relaxation training in 160 patients with breast cancer undergoing adjuvant radiotherapy. To determine the effect of exercise itself beyond potential psychosocial group effects, patients in the control group perform a group-based progressive muscle relaxation training. Main inclusion criterion is histologically confirmed breast cancer stage I-III after lumpectomy or mastectomy with indication for adjuvant radiotherapy. Main exclusion criteria are acute infectious diseases, severe neurological, musculosceletal or cardiorespiratory disorders. The primary endpoint is cancer-related fatigue; secondary endpoints include immunological and inflammatory parameters analyzed in peripheral blood, saliva and urine. In addition, QoL, depression, physical performance and cognitive capacity will be assessed.DiscussionThe BEST study is the first randomized controlled trial comparing progressive resistance training with muscle relaxation training in breast cancer patients during adjuvant radiotherapy. Based on the analysis of physiological, immunological and inflammatory parameters it will contribute to a better understanding of the physiological and psychosocial effects and the biological mechanisms of resistance training. The ultimate goal is the implementation of optimized intervention programs to reduce fatigue, improve quality of life and potentially the prognosis after breast cancer.Trial registrationClinicalTrials.gov NCT01468766

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Progressive resistance versus relaxation training for breast cancer patients during adjuvant chemotherapy: Design and rationale of a randomized controlled trial (BEATE study)

Cited by 34 publications

References 63 publications

Muscle strength in breast cancer patients receiving different treatment regimes

Muscle strength in breast cancer patients receiving different treatment regimes

Cancer-related fatigue shows a stable association with diurnal cortisol dysregulation in breast cancer patients

Randomized controlled trial to evaluate the effects of progressive resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the BEST study

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