Progressive resistance in a single strain of Acinetobacter calcoaceticus recovered during a nonsocomial outbreak

Carlquist, John F.; Conti, Marlyn T.; Burke, John P.

doi:10.1016/0196-6553(82)90001-3

Cited by 23 publications

(12 citation statements)

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“…In order to find ways to contain these outbreaks, European countries started the search for risk factors. These studies led to the establishment of an association between ventilator use and increased mortality with strains that were resistant to more than three antibiotic groups [ 19 – 21 ]. These strains were therefore designated as multidrug-resistant (MDR) microorganisms.…”

Section: Outbreak Increase and Cumulative Antibiotic Resistance: 1mentioning

confidence: 99%

Antibiotic-ResistantAcinetobacter baumanniiIncreasing Success Remains a Challenge as a Nosocomial Pathogen

González-Villoria

Valverde-Garduño²

2016

Journal of Pathogens

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Antibiotic-resistant infectious bacteria currently imply a high risk and therefore constitute a strong challenge when treating patients in hospital settings. Characterization of these species and of particular strains is a priority for the establishment of diagnostic tests and preventive procedures. The relevance of Acinetobacter baumannii as a problematic microorganism in inpatient facilities, particularly intensive care units, has increased over time. This review aims to draw attention to (i) the historical emergence of carbapenem-resistant Acinetobacter baumannii, (ii) the current status of surveillance needs in Latin America, and (iii) recent data suggesting that A. baumannii continues to spread and evolve in hospital settings. First, we present synopsis of the series of events leading to the discovery and precise identification of this microorganism in hospital settings. Then key events in the acquisition of antibiotic-resistant genes by this microorganism are summarized, highlighting the race between new antibiotic generation and emergence of A. baumannii resistant strains. Here we review the historical development of this species as an infectious threat, the current state of its distribution, and antibiotic resistance characteristics, and we discuss future prospects for its control.

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Section: Outbreak Increase and Cumulative Antibiotic Resistance: 1mentioning

confidence: 99%

Antibiotic-ResistantAcinetobacter baumanniiIncreasing Success Remains a Challenge as a Nosocomial Pathogen

González-Villoria

Valverde-Garduño²

2016

Journal of Pathogens

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“…Deadly cases of community-acquired pneumonia have been reported among immune-compromised patients [392,393]. These infections are difficult to treat due to the expanding antibiotic resistance of clinical strains [394,395]. Acinetobacter baumannii is a metabolically versatile pathogen, yet little is known about the genes and factors involved in its basic physiology and virulence properties.…”

Section: Disease Diagnosis Using the Electronic Nosementioning

confidence: 99%

Advances in Electronic-Nose Technologies Developed for Biomedical Applications

Wilson

Baietto

2011

Sensors

328

236

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The research and development of new electronic-nose applications in the biomedical field has accelerated at a phenomenal rate over the past 25 years. Many innovative e-nose technologies have provided solutions and applications to a wide variety of complex biomedical and healthcare problems. The purposes of this review are to present a comprehensive analysis of past and recent biomedical research findings and developments of electronic-nose sensor technologies, and to identify current and future potential e-nose applications that will continue to advance the effectiveness and efficiency of biomedical treatments and healthcare services for many years. An abundance of electronic-nose applications has been developed for a variety of healthcare sectors including diagnostics, immunology, pathology, patient recovery, pharmacology, physical therapy, physiology, preventative medicine, remote healthcare, and wound and graft healing. Specific biomedical e-nose applications range from uses in biochemical testing, blood-compatibility evaluations, disease diagnoses, and drug delivery to monitoring of metabolic levels, organ dysfunctions, and patient conditions through telemedicine. This paper summarizes the major electronic-nose technologies developed for healthcare and biomedical applications since the late 1980s when electronic aroma detection technologies were first recognized to be potentially useful in providing effective solutions to problems in the healthcare industry.

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“…anitratus (15), belongs to a bacterial species that is widely distributed throughout the environment (6). This microorganism can be isolated from the skin (3, 43) and respiratory tract (59) of healthy ambulatory adults as well as from hospital personnel and equipment (36,39,46,67).Lately, numerous outbreaks of nosocomial infections caused by A. baumannii have been reported (7-10, 16, 42, 47, 56, 57, 73), which are of particular concern because of the widespread and increasing antibiotic resistance of the isolated strains (17,30,32,33,40,41,48). Nevertheless, most infections have occurred in patients compromised by either antibiotic therapy, respiratory instrumentation and manipulations, dialysis, or surgery (18,19,39,70).…”

mentioning

confidence: 99%

“…Lately, numerous outbreaks of nosocomial infections caused by A. baumannii have been reported (7-10, 16, 42, 47, 56, 57, 73), which are of particular concern because of the widespread and increasing antibiotic resistance of the isolated strains (17,30,32,33,40,41,48). Nevertheless, most infections have occurred in patients compromised by either antibiotic therapy, respiratory instrumentation and manipulations, dialysis, or surgery (18,19,39,70).…”

mentioning

confidence: 99%

Characterization of a high-affinity iron transport system in Acinetobacter baumannii

et al. 1992

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Analysis of a clinical isolate ofAcinetobacter baumannii showed that this bacterium was able to grow under iron-limiting conditions, using chemically defined growth media containing different iron chelators such as human transferrin, ethylenediaminedi-(o-hydroxyphenyl)acetic acid, nitrilotriacetic acid, and 2,2'-bipyridyl. This iron uptake-proficient phenotype was due to the synthesis and secretion of a catechol-type siderophore compound. Utilization bioassays using the SalmoneUla typhimurium iron uptake mutants enb-1 and enb-7 proved that this siderophore is different from enterobactin. This catechol siderophore was partially purified from culture supernatants by adsorption chromatography using an XAD-7 resin. The purified component exhibited a chromatographic behavior and a UV-visible light absorption spectrum different from those of 2,3-dihydroxybenzoic acid and other bacterial catechol siderophores. Furthermore, the siderophore activity of this extraceliular catechol was confirmed by its ability to stimulate energy-dependent uptake of 55Fe(M) as well as to promote the growth of A. baumannii bacterial cells under iron-deficient conditions imposed by 60 ,uM human transferrin. Polyacrylamide gel electrophoresis analysis showed the presence of iron-regulated proteins in both inner and outer membranes of this clinical isolate ofA. baumannii. Some of these membrane proteins may be involved in the recognition and internalization of the iron-siderophore complexes.Acinetobacter baumannii, formerly known asAcinetobacter calcoaceticus subsp. anitratus (15), belongs to a bacterial species that is widely distributed throughout the environment (6). This microorganism can be isolated from the skin (3, 43) and respiratory tract (59) of healthy ambulatory adults as well as from hospital personnel and equipment (36,39,46,67).Lately, numerous outbreaks of nosocomial infections caused by A. baumannii have been reported (7-10, 16, 42, 47, 56, 57, 73), which are of particular concern because of the widespread and increasing antibiotic resistance of the isolated strains (17,30,32,33,40,41,48). Nevertheless, most infections have occurred in patients compromised by either antibiotic therapy, respiratory instrumentation and manipulations, dialysis, or surgery (18,19,39,70). Thus, it was proposed that reduced host defenses and interaction with other bacterial species, rather than the expression of specific bacterial virulence factors (49), are the factors responsible for opportunistic infections caused by Acinetobacter species.Acinetobacter species are able to survive under restricted nutrient conditions, such as those imposed by the host. Iron is one of the essential bacterial nutrients that is tightly controlled by the host, through its chelation by the highaffinity binding glycoproteins transferrin (TF) and lactoferrin (23). Thus, bacteria have developed efficient iron uptake mechanisms that allow them to scavenge iron from these host proteins, either by direct interaction with the ironprotein complexes (34) or by the synthesis an...

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Progressive resistance in a single strain of Acinetobacter calcoaceticus recovered during a nonsocomial outbreak

Cited by 23 publications

References 10 publications

Antibiotic-ResistantAcinetobacter baumanniiIncreasing Success Remains a Challenge as a Nosocomial Pathogen

Antibiotic-ResistantAcinetobacter baumanniiIncreasing Success Remains a Challenge as a Nosocomial Pathogen

Advances in Electronic-Nose Technologies Developed for Biomedical Applications

Characterization of a high-affinity iron transport system in Acinetobacter baumannii

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