Progressive Resistance Exercise Training Attenuated Renal Damages, but did not improve Muscle Force in STZ-Induced Diabetic Rats

Silva, Kleiton Augusto Santos; Santos, Ralmony de Alcântara; Arlotti, Marcelo R; Jorge, Luciana; Luiz, Rafael da Silva; Rampaso, Rodolfo Rosseto; Cunha, Tatiana Sousa; Schor, Nestor

doi:10.4172/2155-6156.1000461

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Silva et al also showed that the renal amounts of TGF-β1 in diabetic rats were higher compared to healthy rats, which significantly decreased after 8 weeks of resistance training (29). In the condition of diabetes, the increase in glucose levels leads to the production of angiotensin II in cardiac myocytes and fibroblasts, which is associated with the positive regulation of collagen synthesis and the production of TGF-ß in the cardiac tissue (29,30). Therefore, high levels of angiotensin II, glucose, and oxidative stress may lead to structural changes and cardiac fibrosis through the reduction of matrix metalloproteinase-2 activity and the increase of TGF-ß1 (30,31).…”

Section: Discussionmentioning

confidence: 97%

“…Kwak et al concluded that 12 weeks of aerobic exercise led to a decrease in TGF-β levels in the left ventricular tissue of old rats (19). Silva et al also showed that the renal amounts of TGF-β1 in diabetic rats were higher compared to healthy rats, which significantly decreased after 8 weeks of resistance training (29). In the condition of diabetes, the increase in glucose levels leads to the production of angiotensin II in cardiac myocytes and fibroblasts, which is associated with the positive regulation of collagen synthesis and the production of TGF-ß in the cardiac tissue (29,30).…”

Section: Discussionmentioning

confidence: 99%

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The effect of eight weeks of high-intensity interval training on the expression of mir-126, EMAP-II, and levels of TGF-β in the heart tissue of young rats with type 2 diabetes

Bagherinia,

Abedi,

Fatolahi

2023

J Shahrekord Univ Med Sci

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Background and aims: Diabetes affects some cardiac angiogenic and antiangiogenic markers. Thus, the aim of this study was to investigate the effect of eight weeks of high-intensity interval training (HIIT) on mir-126, endothelial monocyte-activating polypeptide II (EMAP-II), and transforming growth factor beta (TGF-β) in young rats with type 2 diabetes (T2D). Methods: The statistical population of this experimental study included young rats (8 weeks old) with T2D. In this research, 24 young rats (8 weeks old) were divided into healthy+HIIT, diabetic+HIIT, and healthy control groups. The enzyme-linked immunosorbent assay method was used to measure TGF-β and the real-time polymerase chain reaction for mir-126 and EMAP-II. A one-way analysis of variance and the least significant difference post hoc test were used to compare the two groups. Results: The results showed diabetes+HIIT and healthy+HIIT had more mir-126 compared to healthy control (P=0.001). Healthy+HIIT, in comparison to diabetes+HIIT, had higher mir-126 expression (P=0.001). In addition, diabetes+HIIT, compared to the healthy control, had a higher EMAP-II expression (P=0.006). On the other hand, healthy+HIIT had lower EMAP-II in comparison to healthy control (P=0.001). Healthy+HIIT had a lower EMAP-II compared to diabetes+HIIT (P=0.001). Diabetes+HIIT, in comparison to the healthy control, had higher TGF-β levels (P=0.005). However, healthy+HIIT, compared to healthy control, had a lower expression of TGF-β (P=0.001). Finally, the healthy+HIIT groups, compared to the diabetes+HIIT group, had a lower TGF-β expression (P=0.001). Conclusion: Interval exercise could increase angiogenesis in diabetic samples through the increase of mir-126 and the reduction of TGF-β1 and EMAP-II.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

The effect of eight weeks of high-intensity interval training on the expression of mir-126, EMAP-II, and levels of TGF-β in the heart tissue of young rats with type 2 diabetes

Bagherinia,

Abedi,

Fatolahi

2023

J Shahrekord Univ Med Sci

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Impact of different exercise training on mitochondrial in diabetic nephropathy

Jorge¹,

Reinecke²,

Silva³

et al. 2021

JDMDC

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The purpose of this study was to compare the effects of aerobic, resistance and combined exercise training on mitochondrial dysfunction in diabetic nephropathy in rats. Male Wistar rats were divided into eight groups: non-diabetics (untrained, trained aerobic, trained resistance, trained combined), diabetic (untrained, trained aerobic, trained resistance, trained combined). Serum glucose levels, maximum effort test, renal function and mitochondrial biogenesis were assessed. Western blot and immunohistochemistry were used to evaluate the expression of the mitochondrial biogenesis protein and Acetil-CoA carboxylase. No differences were observed in body weight and glycaemia between diabetic rats. Diabetic animals and controls in the trained aerobic and combined groups exhibited an increase in running time, whereas animals in the trained resistance and combined groups showed greater strength. Our data suggest that exercise training can modulate the molecular pathways involved in mitochondrial biogenesis and control of renal system, decreasing the progression of diabetic nephropathy and indicating that renal disease can be prevented with non-pharmacological treatments. In conclusion, the three training protocols led to an increase in physical capacity and mitochondrial and renal benefits that were not dependent on improvements in glycemic control. In this model, combined training seems to promote more benefits than resistance or aerobic training alone.

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The effect of 6 weeks moderate intensity endurance training on skeletal muscle fibrosis in diabetic rats

Amani

Rahmati

Fathi

et al. 2020

Med J

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Progressive Resistance Exercise Training Attenuated Renal Damages, but did not improve Muscle Force in STZ-Induced Diabetic Rats

Cited by 3 publications

References 32 publications

The effect of eight weeks of high-intensity interval training on the expression of mir-126, EMAP-II, and levels of TGF-β in the heart tissue of young rats with type 2 diabetes

The effect of eight weeks of high-intensity interval training on the expression of mir-126, EMAP-II, and levels of TGF-β in the heart tissue of young rats with type 2 diabetes

Impact of different exercise training on mitochondrial in diabetic nephropathy

The effect of 6 weeks moderate intensity endurance training on skeletal muscle fibrosis in diabetic rats

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