Progressive Nodular Histiocytoma

Burgdorf, Walter H. C.; Kusch, Stanferd Lee; Nix, Thomas; Piťha, Jan

doi:10.1001/archderm.1981.01650100046027

Cited by 43 publications

(32 citation statements)

References 16 publications

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“…Among the various types of NLCH, progressive nodular histiocytosis (PNH) [1, 4, 5, 6, 7, 8, 9, 10]is clinically the most similar to our case. In our patient, however, both the nodular lesions typical of PNH and the facies leonina sometimes associated with this disease were absent.…”

Section: Commentsupporting

confidence: 64%

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Progressive Histiocytosis: Description of a Case of Slow-Course Non-Langerhans Cell Histiocytosis

Caputo

Brezzi²,

Vaccari³

et al. 2002

Dermatology

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We describe the case of a 37-year-old male patient who in 1992 started developing a skin eruption characterized by dark red to red-yellow papulonodular lesions that showed no tendency to spontaneous resolution. Visceral organs were not involved and the lipid pattern was basically normal. Histological examination revealed an infiltrate in the mid and upper dermis mainly consisting of mononucleated and multinucleated histiocytes with an abundant eosinophilic cytoplasm and a ground glass appearance, admixed with numerous xanthomatized cells and Touton and foreign-body giant cells. Immunohistochemical studies showed positivity for CD68 and negativity for CD1a and S-100 protein, whereas at the electron microscopy level the only peculiar finding was the presence of many desmosome-like junctions. The authors believe this to be a borderline form between papular xanthoma and reticulohistiocytosis.

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Section: Commentsupporting

confidence: 64%

“…This finding has been explained as a feature acquired under pathological conditions by histiocytes rich in small coated vesicles which fuse with the plasma membrane [15]. In 1981, Burgdorf et al [5]reported the presence of a single desmosome in a case of PNH.…”

Section: Commentmentioning

confidence: 99%

Progressive Histiocytosis: Description of a Case of Slow-Course Non-Langerhans Cell Histiocytosis

Caputo

Brezzi²,

Vaccari³

et al. 2002

Dermatology

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“…The latter may also occur sporadically [1,12]. In our patients, the nodules were the predominant clinical feature.…”

Section: Commentsmentioning

confidence: 47%

Progressive nodular histiocytosis

Hilker

Kovneristy²,

Varga³

et al. 2012

J Deutsche Derma Gesell

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SummaryProgressive nodular histiocytosis (PNH) represents a very rare type of non-Langerhans cell histiocytosis (NLCH). It can be distinguished from other types by the occurrence of yellow to red-brown papules and nodules measuring a few centimeters in size. Histologically the nodules represent spindle-cell xanthogranulomas. We report on two new cases of PNH with novel clinical symptoms. In the first case, the patient had microcytic anemia due to massive iron deposition in the nodules and a progressively worsening limp due to involvement of the soles. The complex therapeutic challenge was effectively managed by successive surgical ablation of all visible lesions. The second patient had epibulbar infiltrates. The clinical variability of PNH leads to considerable overlap with other forms of NLCH.

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“…Despite the progressive nature of the lesions, patients remain in good health and usually without visceral involvement. The clinical features of the progressive form of PX are practically identical to those observed in the so-called progressive nodular histiocytosis (PNH) [12, 13, 14, 15, 16, 17, 18]. …”

Section: Discussionmentioning

confidence: 89%

Papular Xanthoma Associated with Angiokeratoma of Fordyce: Considerations on the Nosography of This Rare Non-Langerhans Cell Histiocytoxanthomatosis

Caputo¹,

Passoni²,

Cavicchini³

2003

Dermatology

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Background: Papular xanthoma (PX) is a rare normolipidemic non-Langerhans cell histiocytoxanthomatosis affecting both children and adults. Objective: We describe an adult case of PX associated with angiokeratoma of Fordyce and review the literature in order to compare and discuss previous reports. Methods: We studied the clinical, histopathological, immunocytochemical and ultrastructural findings. Results: We report the findings of our case and compare our case with those described in the literature. Conclusions: Three clinical patterns of PX appeared to emerge in the review of the literature: a self-healing form, a persistent form and a progressive form. The progressive form of PX can be considered the same clinical entity that is also described as progressive nodular histiocytosis.

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Progressive Nodular Histiocytoma

Cited by 43 publications

References 16 publications

Progressive Histiocytosis: Description of a Case of Slow-Course Non-Langerhans Cell Histiocytosis

Progressive Histiocytosis: Description of a Case of Slow-Course Non-Langerhans Cell Histiocytosis

Progressive nodular histiocytosis

Papular Xanthoma Associated with Angiokeratoma of Fordyce: Considerations on the Nosography of This Rare Non-Langerhans Cell Histiocytoxanthomatosis

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