Progressive multifokale Leukoenzephalopathie: Spätkomplikation bei chronischer lymphatischer Leukämie

Abstract

In a 44 year old patient with chronic lymphatic leukemia and secondary antibody deficiency syndrome, a disorder of articulation and a left hemiparesis developed during a thrombocytopenic phase. Computer tomography of the cranium, CSF diagnostics and the electroencephalogram did not provide any indication for the cause of the rapidly progressive cerebral symptoms. In the NMR tomogram, a diffusedly increasing intensity in the T2-weighted tomograms were shown around the central region in the right brain. The patient died of a Pseudomonas septicemia. At autopsy, a typical finding of progressive multifocal leukoencephalopathy was found in the areas altered in the NMR tomography. Papova-like virions could be demonstrated in glial cells by electron microscopy.

Molecular Regulation of JC Virus Tropism: Insights into Potential Therapeutic Targets for Progressive Multifocal Leukoencephalopathy

“…PML is an extremely rare, yet fatal, disease that primarily occurs in immune suppressed individuals such as individuals suffering from leukemia (Behar 1965; Aur et al 1978; GiaRusso and Koeppen 1978; Hofeler et al 1987; Yamamoto et al 1987; Flanagan and Costello 1989; Heikens et al 1992; Nowak-Michalska et al 1993; Farge et al 1994; Ganguly et al 1995; Seong et al 1996; Coppo et al 1999; Attout et al 2000; Cid et al 2000; Mata et al 2000; Alla et al 2001; Bagnato et al 2001; Leonard et al 2002; Saumoy et al 2002; Kiewe et al 2003; Swamy and Nardino 2003; Hasan and Taylor 2005; Malkoun et al 2006; Robb et al 2006; Matsuo et al 2007; Kesari et al 2008). During the AIDS epidemic, PML emerged as an AIDS defining illness that occurs in approximately 3% of HIV-infected patients (Major 2010).…”